Gm4995, a predicted gene with DNA-binding transcription factor activity specific to RNA polymerase II transcription regulatory regions, plays a crucial role in governing gene expression within the cellular landscape. Positioned as a key player in the intricate regulatory network, Gm4995 orchestrates transcriptional machinery, exerting influence over the fate of downstream genes. Its predicted involvement in the regulation of transcription by RNA polymerase II underscores its significance in shaping the cellular processes that govern transcription.
The activation of Gm4995 involves a sophisticated interplay of various chemical modulators, each targeting specific cellular pathways that either directly or indirectly impact its DNA-binding transcription factor activity. These pathways, including retinoic acid signaling, histone modification, cAMP elevation, and MAPK cascades, contribute to the nuanced regulation of Gm4995. The intricate network of activation mechanisms highlights the adaptability of Gm4995 to respond to diverse intracellular signals and environmental cues, underscoring its role as a central regulator in the fine-tuning of gene expression. The interplay between chemical modulators and Gm4995 provides insights into the complex regulatory dynamics governing transcriptional processes, emphasizing the multifaceted nature of gene expression control within the cellular milieu.
関連項目
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | ¥733.00 ¥3599.00 ¥6487.00 ¥11259.00 | 28 | |
通过与视黄酸受体结合上调 Gm4995,影响 DNA 结合转录因子特异性 RNA 聚合酶 II 的活性。增强转录物的调控功能。 | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | ¥1681.00 ¥5303.00 ¥6995.00 ¥13527.00 ¥23579.00 | 33 | |
HDAC 抑制剂,影响染色质结构,间接促进 Gm4995。增强 RNA 聚合酶 II 调控区的 DNA 结合特异性。 | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | ¥338.00 ¥519.00 ¥925.00 ¥2459.00 | 19 | |
改变组蛋白乙酰化,促进 Gm4995 的功能。增强 DNA 与 RNA 聚合酶 II 转录调控区的结合特异性。 | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | ¥440.00 ¥1015.00 | 212 | |
MEK 抑制剂,影响 MAPK 通路,间接促进 Gm4995。改变细胞内信号级联,增强 DNA 与 RNA 聚合酶 II 调控区的结合。 | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | ¥1365.00 ¥4423.00 | 148 | |
PI3K 抑制剂,影响 PI3K/Akt 通路,间接上调 Gm4995。调节细胞内信号传导,促进 DNA 结合转录因子特异性地作用于 RNA 聚合酶 II 的活性。 | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | ¥993.00 ¥3858.00 | 284 | |
p38 MAPK 抑制剂,影响 MAPK 通路,间接增强 Gm4995。改变细胞信号级联,促进 DNA 与 RNA 聚合酶 II 转录调控区的结合。 | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | ¥2550.00 ¥9545.00 | 1 | |
BET抑制剂影响溴结构域蛋白,促进Gm4995活性。调节染色质结构,增强DNA结合转录因子对RNA聚合酶II调控区域的特异性活性。 | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | ¥406.00 ¥1241.00 ¥4513.00 | ||
G9a抑制剂影响组蛋白甲基化,促进Gm4995功能。调节表观遗传标记,增强RNA聚合酶II调控区域特异的DNA结合转录因子活性。 | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | ¥1974.00 | ||
Dvl PDZ 结构域抑制剂,影响 Wnt 信号转导,间接促进 Gm4995。改变 Dishevelled 的功能,增强 DNA 与 RNA 聚合酶 II 转录调控区的结合。 | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | ¥677.00 ¥2087.00 ¥4118.00 | 64 | |
通过激活 SIRT1 增强 Gm4995 的活性,影响 DNA 结合转录因子特异性地作用于 RNA 聚合酶 II 转录调控区的活性。调节细胞通路,促进转录调节功能。 |