Date published: 2025-10-10

021-6093-6350

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β-1,4-GalNAc-T4激活剂

GalNAc-T4 Activators refers to a group of compounds that potentially influence the function or regulation of GalNAc-T4 indirectly, primarily through their effects on glycosylation processes and related cellular pathways. These activators target various aspects of protein modification, Golgi apparatus function, and proteostasis, reflecting the potential involvement of GalNAc-T4 in these processes. Compounds like Benzyl-α-GalNAc, which inhibits mucin-type O-glycosylation, and Tunicamycin, an N-linked glycosylation inhibitor, can indirectly influence the glycosylation landscape within cells, potentially impacting GalNAc-T4 activity. Swainsonine, Castanospermine, and Kifunensine, by inhibiting specific glycosylation-related enzymes, demonstrate the interconnected nature of glycosylation pathways and their potential indirect impact on GalNAc-T4. Brefeldin A and Monensin disrupt Golgi apparatus function, a key site for glycosylation, potentially affecting the function and localization of GalNAc-T4 in glycosylation processes.

Deoxynojirimycin and 1-Deoxymannojirimycin, as α-glucosidase and α-mannosidase inhibitors, respectively, could indirectly influence GalNAc-T4 by affecting glycoprotein processing. Proteasome inhibitors like Clasto-Lactacystin β-Lactone and MG132 highlight the role of protein turnover in regulating enzymes like GalNAc-T4, potentially impacting its activity through modulation of protein stability. Ammonium Chloride, by affecting lysosomal pH, could impact lysosomal degradation pathways, indirectly influencing the activity and stability of GalNAc-T4. Overall, the study of GalNAc-T4 activators, primarily through indirect mechanisms, underscores the complexity of glycosylation processes and the importance of understanding how various factors, such as glycosylation inhibitors, Golgi function modulators, and proteostasis regulators, can influence the function of key enzymes involved in these processes. This approach is crucial for exploring the roles of enzymes like GalNAc-T4 in the broader context of cellular protein modification and stability.

関連項目

产品名称CAS #产品编号数量价格应用排名

Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside

3554-93-6sc-203427
sc-203427A
100 mg
1 g
¥3949.00
¥35222.00
2
(0)

苄基-α-GalNAc 是粘蛋白型 O-糖基化的抑制剂,可能会通过改变底物的可用性间接影响 GalNAc-T4 的活性。

Kifunensine

109944-15-2sc-201364
sc-201364A
sc-201364B
sc-201364C
1 mg
5 mg
10 mg
100 mg
¥1489.00
¥5968.00
¥11338.00
¥69102.00
25
(2)

甘露糖苷酶抑制剂 Kifunensine 可影响 N-连接糖基化,从而可能影响与 GalNAc-T4 相关的途径。

Ceftriaxone, Disodium Salt, Hemiheptahydrate

104376-79-6sc-211050
sc-211050A
1 g
5 g
¥1974.00
¥4964.00
1
(1)

1-Deoxymannojirimycin 是另一种 α-甘露糖苷酶抑制剂,可通过对糖蛋白加工的影响间接影响 GalNAc-T4。

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
¥1862.00
¥6487.00
60
(2)

这种蛋白酶体抑制剂可影响蛋白质的周转,并可能通过调节蛋白质的稳定性间接影响 GalNAc-T4 的活性。

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
¥632.00
¥2933.00
¥11056.00
163
(3)

另一种蛋白酶体抑制剂 MG132 可能会影响蛋白质降解途径,从而可能影响 GalNAc-T4 的功能。