Date published: 2025-9-8

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ZNF281 抗体 (G-9): sc-137205

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说明书
  • ZNF281抗体(G-9)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 针对氨基酸679-895,在ZNF281的human起源的C-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的ZNF281 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-137205 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是ZNF281 Antibody (G-9) for WB applications. 的首选辅助检测试剂,这些试剂现与ZNF281 Antibody (G-9) 打包提供(请参阅下面的订购信息)。

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関連項目

锌指蛋白含有DNA结合域,并具有多种功能,其中大部分涵盖某种形式的转录激活或抑制。ZNF281,也称为GC盒结合锌指蛋白1、ZBP-99或ZNP-99(锌指DNA结合蛋白99),是一种锌指蛋白,属于Krüppel C2H2型锌指蛋白家族。它在肾脏、肝脏、淋巴细胞和胎盘中普遍低表达,但在这些组织中表达占主导。ZNF281定位于细胞核,并含有四个C2H2型锌指。ZNF281在抑制多种基因(包括胃泌素和ODC(鸟氨酸脱羧酶))的转录中发挥作用。特别是,ZNF281通过与基因增强子区域中的G富集盒结合来发挥作用。在DNA损伤后,ZNF281可能会被Atm或ATR磷酸化。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ZNF281 抗体 (G-9) 参考文献:

  1. ZNF281/ZBP-99:上皮-间质转化、干细胞和癌症的新角色。  |  Hahn, S. and Hermeking, H. 2014. J Mol Med (Berl). 92: 571-81. PMID: 24838609
  2. ZNF281通过Wnt和β-Catenin信号通路调控结肠直肠癌细胞的增殖、迁移和侵袭。  |  Qin, CJ., et al. 2019. Cell Physiol Biochem. 52: 1503-1516. PMID: 31112017
  3. ZNF281/Zfp281 是 miR-1 的靶标,能抑制肌肉分化。  |  Nicolai, S., et al. 2020. Mol Oncol. 14: 294-308. PMID: 31782884
  4. 长链非编码RNA-ZNF281与miR-539相互作用,促进肝细胞癌细胞的侵袭和迁移。  |  Zhang, Z., et al. 2020. Cancer Biother Radiopharm. 35: 137-142. PMID: 32073896
  5. ZNF281-miR-543反馈回路调节转化生长因子-β诱导的乳腺癌转移。  |  Ji, W., et al. 2020. Mol Ther Nucleic Acids. 21: 98-107. PMID: 32512343
  6. ZNF281在TGFβ1诱导的肠道纤维化中促进结肠成纤维细胞活化。  |  Laudadio, I., et al. 2022. Int J Mol Sci. 23: PMID: 36142169
  7. SUFU抑制转录因子ZNF281,从而抑制肿瘤细胞迁移。  |  Deng, Y., et al. 2023. Cell Death Differ. 30: 702-715. PMID: 36220888
  8. ZNF281通过减少HK2稳定的PINK1/Parkin介导的有丝分裂,促使酒精性肝病中的肝细胞衰老。  |  Lu, C., et al. 2023. Cell Prolif. 56: e13378. PMID: 36514923
  9. ZNF281抑制线粒体生物发生,促进肝细胞癌的转移。  |  Zhao, Q., et al. 2023. Cell Death Discov. 9: 396. PMID: 37880213
  10. ZNF281在大肠癌中的表达与对放疗的反应和存活率相关。  |  Qin, C., et al. 2023. Ann Med. 55: 2278619. PMID: 37939252

订购信息

产品名称产品编号规格价格数量收藏夹

ZNF281 抗体 (G-9)

sc-137205
200 µg/ml
RMB2377.00

ZNF281 (G-9): m-IgG Fc BP-HRP 套装

sc-539958
200 µg Ab; 10 µg BP
RMB2662.00

ZNF281 (G-9): m-IgG1 BP-HRP 套装

sc-541814
200 µg Ab; 20 µg BP
RMB2662.00

ZNF281 抗体 (G-9) X

sc-137205 X
200 µg/0.1 ml
RMB2377.00

When should the TransCruz reagent sc-137205 X be used instead of the standard form sc-137205?

Asked by: AbPolly
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Strong band in WB in mouse transfected 293TStrong band in WB in mouse transfected 293T whole cell lysates and KNRK nuclear extract. -SCBT QC
Date published: 2015-05-10
Rated 5 out of 5 by from Published WB data with human normal prostatePublished WB data with human normal prostate epithelial cells (PreC), DU145 and PC3 prostate cancer cells - SCBT Publication Review
Date published: 2015-04-18
Rated 5 out of 5 by from Great immunofluorescence nuclear stainingGreat immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2014-09-10
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ZNF281 抗体 (G-9) is rated 5.0 out of 5 by 3.
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