Biberger and von Angerer (1996) 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol. 58 31. Liu et al (1999) The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system. Biol.Chem. 380 1341. Walter et al (2004) Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg.Med.Chem.Lett. 14 4659.
抑制剂:
Estrogen Receptor.
物理状态 :
Solid
溶解度 :
Soluble in ethanol (25 mM), and DMSO (100 mM).
保存 :
Store at room temperature
沸点 :
~712.4° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.57 (Predicted)
IC50 :
The growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro: IC50 = ~1 nM (human); Estrogen receptor: IC50 = 1.4 nM (human); 17β-estradiol stimulation of luciferase activity: IC50 = 25 nM
pK值 :
pKa: 10.18 (Predicted)
仅供科研使用。不可用于诊断或治疗。 Available in US only.
运输 :
Not available for sale outside of the United States.