Date published: 2025-9-8

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ZBP-89 抗体 (E-7): sc-137169

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说明书
  • ZBP-89抗体(E-7)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对氨基酸611-794,在ZBP-89的human起源的C-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的ZBP-89 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-137169 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是ZBP-89 Antibody (E-7) for WB applications. 的首选辅助检测试剂,这些试剂现与ZBP-89 Antibody (E-7) 打包提供(请参阅下面的订购信息)。

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    関連項目

    ZBP-89,也被称为BFCOL1、BERF1和ZNF 148,是一种普遍表达的锌指转录因子。ZBP-89是一种类似Kruppel的阻遏蛋白,是波形蛋白的沉默元件结合因子。已证明ZBP-89能与胃泌素、鸟氨酸脱羧酶和细胞周期蛋白依赖性激酶抑制剂p21(也称为Cip1或WAF1)的启动子中的富含GC的DNA元件结合。ZBP-89的表达由反式视黄酸或丁酸盐诱导,后者也能诱导结肠癌细胞的终末分化。ZBP-89与组蛋白乙酰转移酶共激活因子p300协同调节p21,p21是一种细胞周期蛋白依赖性激酶抑制剂,其相关基因是p53的靶基因。ZBP-89还通过其直接结合p53蛋白并延缓其核输出的能力,部分地调节细胞增殖。ZBP-89水平的升高会诱导人胃肠道细胞的生长停滞和凋亡。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    ZBP-89 抗体 (E-7) 参考文献:

    1. 转录因子ZBP-89在癌症生长和凋亡中的作用。  |  Zhang, CZ., et al. 2010. Biochim Biophys Acta. 1806: 36-41. PMID: 20230874
    2. ZBP-89在人类珠蛋白基因调控和红细胞分化中的作用。  |  Woo, AJ., et al. 2011. Blood. 118: 3684-93. PMID: 21828133
    3. ZBP-89与p53突变体之间的相互作用及其对HDACi治疗肝癌效果的贡献  |  Zhang, CZ., et al. 2012. Cell Cycle. 11: 322-34. PMID: 22214764
    4. 在 Pin1 存在的情况下,ZBP-89 通过降解 IkappaB 减少组蛋白去乙酰化酶 3。  |  Ye, CG., et al. 2015. J Transl Med. 13: 23. PMID: 25623232
    5. 锌结合蛋白-89(ZBP-89)与NF-κB协同作用,调节基质金属蛋白酶(MMP)的表达,以应对炎症细胞因子。  |  Borghaei, RC., et al. 2016. Biochem Biophys Res Commun. 471: 503-9. PMID: 26891870
    6. 转录因子ZBP-89驱动结肠癌中β-Catenin表达的前馈回路。  |  Essien, BE., et al. 2016. Cancer Res. 76: 6877-6887. PMID: 27758879
    7. ZBP-89和Sp1有助于肝癌细胞中Bak的表达。  |  Kong, X., et al. 2018. BMC Cancer. 18: 419. PMID: 29653560
    8. 靶向ZBP-89治疗肝癌。  |  Wang, N., et al. 2018. Expert Opin Ther Targets. 22: 817-822. PMID: 30142986
    9. ZBP-89通过抑制Notch1信号通路,对肝癌干细胞的自我更新产生负向调节作用。  |  Wang, N., et al. 2020. Cancer Lett. 472: 70-80. PMID: 31874246
    10. ZBP-89是一种Krüppel样锌指蛋白,可抑制表皮生长因子对胃泌素启动子的诱导。  |  Merchant, JL., et al. 1996. Mol Cell Biol. 16: 6644-53. PMID: 8943318

    订购信息

    产品名称产品编号规格价格数量收藏夹

    ZBP-89 抗体 (E-7)

    sc-137169
    200 µg/ml
    RMB2377.00

    ZBP-89 (E-7): m-IgG Fc BP-HRP 套装

    sc-539952
    200 µg Ab; 10 µg BP
    RMB2662.00

    ZBP-89 (E-7): m-IgG1 BP-HRP 套装

    sc-541809
    200 µg Ab; 20 µg BP
    RMB2662.00

    ZBP-89 抗体 (E-7) X

    sc-137169 X
    200 µg/0.1 ml
    RMB2377.00

    When should the TransCruz reagent sc-137169 X be used instead of the standard form sc-137169?

    Asked by: Randy McDonald
    Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Great immunofluorescence nuclear stainingGreat immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
    Date published: 2015-03-02
    Rated 5 out of 5 by from Good Western Blot data of ZBPGood Western Blot data of ZBP-89 expression in non-transfected and mouse ZBP-89 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2013-12-26
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    ZBP-89 抗体 (E-7) is rated 5.0 out of 5 by 2.
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