Date published: 2025-9-8

021-6093-6350

SCBT Portrait Logo
Seach Input

ZBP-89 抗体 (D-10): sc-137170

5.0(2)
寫評論提問

说明书
  • ZBP-89抗体(D-10)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对氨基酸611-794,在ZBP-89的human起源的C-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的ZBP-89 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-137170 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是ZBP-89 Antibody (D-10) for WB applications. 的首选辅助检测试剂,这些试剂现与ZBP-89 Antibody (D-10) 打包提供(请参阅下面的订购信息)。

    快捷链接

    関連項目

    ZBP-89,也被称为BFCOL1、BERF1和ZNF 148,是一种普遍表达的锌指转录因子。ZBP-89是一种类似Kruppel的阻遏蛋白,是波形蛋白的沉默元件结合因子。已证明ZBP-89能与胃泌素、鸟氨酸脱羧酶和细胞周期蛋白依赖性激酶抑制剂p21(也称为Cip1或WAF1)的启动子中的富含GC的DNA元件结合。ZBP-89的表达由反式视黄酸或丁酸盐诱导,后者也能诱导结肠癌细胞的终末分化。ZBP-89与组蛋白乙酰转移酶共激活因子p300协同调节p21,p21是一种细胞周期蛋白依赖性激酶抑制剂,其相关基因是p53的靶基因。ZBP-89还通过其直接结合p53蛋白并延缓其核输出的能力,部分地调节细胞增殖。ZBP-89水平的升高会诱导人胃肠道细胞的生长停滞和凋亡。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    ZBP-89 抗体 (D-10) 参考文献:

    1. ZBP-89 通过稳定 p53 促进生长停滞。  |  Bai, L. and Merchant, JL. 2001. Mol Cell Biol. 21: 4670-83. PMID: 11416144
    2. ZBP-89 通过与转录激活因子 Sp1 相互作用,抑制波形蛋白基因的转录。  |  Zhang, X., et al. 2003. Nucleic Acids Res. 31: 2900-14. PMID: 12771217
    3. ZBP-89诱导的细胞凋亡不依赖于p53,但需要JNK。  |  Bai, L., et al. 2004. Cell Death Differ. 11: 663-73. PMID: 14963412
    4. 肠碱性磷酸酶基因表达受ZBP-89激活。  |  Malo, MS., et al. 2006. Am J Physiol Gastrointest Liver Physiol. 290: G737-46. PMID: 16384873
    5. ZBP-89的同种型易患结肠炎。  |  Law, DJ., et al. 2006. Nucleic Acids Res. 34: 1342-50. PMID: 16517939
    6. 转录因子ZBP-89通过组蛋白修饰机制抑制p16表达,从而影响细胞衰老。  |  Feng, Y., et al. 2009. FEBS J. 276: 4197-206. PMID: 19583777
    7. ZBP-89的表达增加及其在肝细胞癌中的预后意义。  |  Zhang, CZ., et al. 2012. Histopathology. 60: 1114-24. PMID: 22372401
    8. 透明细胞肾细胞癌患者中ZBP-89的高表达与远端转移和不良预后相关。  |  Cai, MY., et al. 2012. Biochem Biophys Res Commun. 426: 636-42. PMID: 22982674
    9. 在红细胞发育过程中,Zfp281(ZBP-99)与Zfp148(ZBP-89)共同发挥功能冗余的作用。  |  Woo, AJ., et al. 2019. Blood Adv. 3: 2499-2511. PMID: 31455666
    10. 转录因子ZBP-89调节鸟氨酸脱羧酶启动子的活性。  |  Law, GL., et al. 1998. J Biol Chem. 273: 19955-64. PMID: 9685330

    订购信息

    产品名称产品编号规格价格数量收藏夹

    ZBP-89 抗体 (D-10)

    sc-137170
    200 µg/ml
    RMB2377.00

    ZBP-89 (D-10): m-IgG Fc BP-HRP 套装

    sc-539953
    200 µg Ab; 10 µg BP
    RMB2662.00

    ZBP-89 (D-10): m-IgG1 BP-HRP 套装

    sc-541810
    200 µg Ab; 20 µg BP
    RMB2662.00

    ZBP-89 抗体 (D-10) X

    sc-137170 X
    200 µg/0.1 ml
    RMB2377.00

    When should the TransCruz reagent sc-137170 X be used instead of the standard form sc-137170?

    Asked by: Germaine
    Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
    Answered by: Technical Support
    Date published: 2017-02-27
    • y_2025, m_9, d_7, h_4CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_137170, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 112ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Produced excellent immunofluorescence nuclearProduced excellent immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
    Date published: 2015-01-08
    Rated 5 out of 5 by from Good Western Blot data of ZBPGood Western Blot data of ZBP-89 expression in non-transfected and mouse transfected 293T whole cell lysates. -SCBT QC
    Date published: 2013-09-02
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_2
    • loc_zh_CN, sid_137170, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 10ms
    • REVIEWS, PRODUCT
    ZBP-89 抗体 (D-10) is rated 5.0 out of 5 by 2.
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_2
    • loc_zh_CN, sid_137170, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 119ms
    • REVIEWS, PRODUCT