Date published: 2025-9-8

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ZAC1 抗体 (C-7): sc-166944

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说明书
  • ZAC1 抗体 C-7 是小鼠单克隆 IgG2b κ,ZAC1抗体, 在5篇文献中引用,规格为200 µg/ml
  • 免疫mouse物种的ZAC1的氨基酸211-510
  • ZAC1 抗体 (C-7) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 ZAC1
  • 抗ZAC1抗体(C-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于ChIP的TransCruz试剂(sc-166944 X, 200 µg/0.1 ml)
  • 关于如何获取ZAC1 (C-7): sc-166944免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRP 是ZAC1 抗体 (C-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与ZAC1 抗体 (C-7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

ZAC1抗体(C-7)是一种IgG2b κ小鼠单克隆ZAC1抗体,可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源ZAC1蛋白。ZAC1抗体(C-7)既可以是非偶联的抗ZAC1抗体形式,也可以是多种偶联形式的抗ZAC1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。多形性腺瘤基因(PLAG1)编码一种锌指蛋白,是唾液腺多形性腺瘤的靶基因。PLAG家族的锌指蛋白包括PLAG1、ZAC1和类PLAG2(PLAGL2)。ZAC1,也称为PLAGL1,通过不同的途径同时控制细胞凋亡和细胞周期停滞。ZAC1还作为核受体的正向或负向转录辅因子,这取决于功能性p53的表达。ZAC1在胚胎中广泛表达,在肝原基、脐带区和神经管中表达最高。PLAGL1也在正常乳腺中表达。PLAGL2作为转录的正调节因子定位于细胞核。PLAGL2和ZAC1结合于DNA共识序列ACGGGGGCCCCTTTA。PLAGL2在脾脏、肺和睾丸中特别丰富地表达,可能参与肿瘤细胞周期停滞和凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ZAC1 抗体 (C-7) 参考文献:

  1. ZAC1靶基因与垂体肿瘤发生。  |  Theodoropoulou, M., et al. 2010. Mol Cell Endocrinol. 326: 60-5. PMID: 20117169
  2. Zac1在小鼠小脑特定神经元亚群的发展中起着关键作用。  |  Chung, SH., et al. 2011. Neural Dev. 6: 25. PMID: 21592321
  3. 神经干细胞中的印记Zac1。  |  Daniel, G., et al. 2015. World J Stem Cells. 7: 300-14. PMID: 25815116
  4. ZAC1在新生儿短暂性糖尿病和葡萄糖代谢中的作用。  |  Hoffmann, A. and Spengler, D. 2015. World J Biol Chem. 6: 95-109. PMID: 26322169
  5. Zac1 通过 Pac1 调控新皮质神经元的分化和迁移  |  Adnani, L., et al. 2015. J Neurosci. 35: 13430-47. PMID: 26424889
  6. ZAC1水平升高会破坏神经发生并促进体内快速重编程。  |  Rraklli, V., et al. 2016. Stem Cell Res. 16: 1-9. PMID: 26610203
  7. Zac1/GPR39 磷酸化 CaMK-II 促使 Pax3 和 Pax7 在成肌过程中发挥不同作用。  |  Yang, Q., et al. 2018. Biochim Biophys Acta Mol Basis Dis. 1864: 407-419. PMID: 29079520
  8. Zac1调节骨关节炎中IL-11的表达。  |  Kuo, CL., et al. 2018. Oncotarget. 9: 32478-32495. PMID: 30197757
  9. 基因表达谱鉴定了Zac1在宫颈癌转移中的作用。  |  Su, HC., et al. 2020. Sci Rep. 10: 11837. PMID: 32678267
  10. 印记基因Zac1调节发育性镉诱导的非酒精性脂肪肝疾病中的脂肪变性。  |  Riegl, SD., et al. 2023. Toxicol Sci. 191: 34-46. PMID: 36200916

订购信息

产品名称产品编号规格价格数量收藏夹

ZAC1 抗体 (C-7)

sc-166944
200 µg/ml
RMB2377.00

ZAC1 (C-7): m-IgG2b BP-HRP 套装

sc-548686
200 µg Ab; 10 µg BP
RMB2662.00

ZAC1 抗体 (C-7) X

sc-166944 X
200 µg/0.1 ml
RMB2377.00

ZAC1 抗体 (C-7) AC

sc-166944 AC
500 µg/ml, 25% agarose
RMB3129.00

ZAC1 抗体 (C-7) HRP

sc-166944 HRP
200 µg/ml
RMB2377.00

ZAC1 抗体 (C-7) FITC

sc-166944 FITC
200 µg/ml
RMB2482.00

ZAC1 抗体 (C-7) PE

sc-166944 PE
200 µg/ml
RMB2580.00

ZAC1 抗体 (C-7) Alexa Fluor® 488

sc-166944 AF488
200 µg/ml
RMB2685.00

ZAC1 抗体 (C-7) Alexa Fluor® 546

sc-166944 AF546
200 µg/ml
RMB2685.00

ZAC1 抗体 (C-7) Alexa Fluor® 594

sc-166944 AF594
200 µg/ml
RMB2685.00

ZAC1 抗体 (C-7) Alexa Fluor® 647

sc-166944 AF647
200 µg/ml
RMB2685.00

ZAC1 抗体 (C-7) Alexa Fluor® 680

sc-166944 AF680
200 µg/ml
RMB2685.00

ZAC1 抗体 (C-7) Alexa Fluor® 790

sc-166944 AF790
200 µg/ml
RMB2685.00

There's 3 bands on the western blot image using 293 cells non-transfected and transfected with mouse Zac1. Can you provide what each of the bands are (specifically the ~132 kDa band) on the western image? Thanks in advance!

Asked by: vcol
Thank you for contacting Santa Cruz Biotechnology. To better assist you please contact our technical service department . (800)-457-3801 or email [email protected]
Answered by: BlakeJ
Date published: 2024-04-19

Can ZAC1 (C-7): sc-166944 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Trav11
Thank you for your question. Yes, ZAC1 (C-7): sc-166944 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-28
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Rated 3 out of 5 by from Maybe it's goodFirst of all, thank you very much for the sample provided by Santa Cruz Biotech Corp, perhaps it's because I did it for the first time , and the results are not satisfactory.
Date published: 2017-11-25
Rated 5 out of 5 by from Produced excellent immunoperoxidase nuclearProduced excellent immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human placenta tissue. -SCBT QC
Date published: 2015-04-09
Rated 5 out of 5 by from Great Western Blot data of ZAC1 expression in nonGreat Western Blot data of ZAC1 expression in non-transfected and mouse ZAC1 transfected 293 whole cell lysates. -SCBT QC
Date published: 2014-07-29
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ZAC1 抗体 (C-7) is rated 4.3 out of 5 by 3.
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