Date published: 2025-9-8

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Xanthine Oxidase 抗体 (A-3): sc-398548

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说明书
  • Xanthine Oxidase 抗体 A-3 是小鼠单克隆 IgG2a κ,Xanthine Oxidase抗体, 在28篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Xanthine Oxidase的氨基酸251-360
  • Xanthine Oxidase 抗体 (A-3) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Xanthine Oxidase
  • 抗Xanthine Oxidase抗体(A-3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Xanthine Oxidase (A-3): sc-398548免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRPm-IgGκ BP-HRP 是 Xanthine Oxidase 抗体 (A-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Xanthine Oxidase 抗体 (A-3) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

黄嘌呤氧化酶抗体(A-3)是一种IgG2a κ型小鼠单克隆黄嘌呤氧化酶抗体(也称为XDH抗体、XOR抗体、XO抗体、黄嘌呤氧化还原酶抗体、XAN1抗体或XDHA抗体),可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学(IHC(P))和酶联免疫吸附试验(ELISA)检测到源自小鼠、大鼠和人类的黄嘌呤氧化酶蛋白。黄嘌呤氧化酶抗体(A-3)既有非偶联型抗黄嘌呤氧化酶抗体形式,也有多种偶联型抗黄嘌呤氧化酶抗体形式,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。将嘌呤代谢为称为黄嘌呤的常见分子是尿酸正常转运的必需过程。黄嘌呤氧化酶是一种黄素蛋白酶,可协调钼并利用NAD+作为电子受体,催化次黄嘌呤氧化为黄嘌呤,然后氧化为尿酸。这种酶的主要形式是黄嘌呤脱氢酶,它是一种同二聚体,可通过巯基氧化或蛋白水解修饰转化为黄嘌呤氧化酶。黄嘌呤氧化酶存在于从细菌到人类的多种生物中,并在哺乳动物组织中普遍表达。在氧化酶形式中,该酶与自由基的产生有关。血清黄嘌呤氧化酶显著升高的个体可能患有慢性肝病和胆汁淤积,这是一种由肝梗阻引起的疾病。肝梗阻会导致胆汁盐、胆汁色素胆红素和脂肪在血液中积聚,而不是正常排泄。黄嘌呤氧化酶缺陷的临床后果从轻度到重度不等,甚至会导致致命性紊乱。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Xanthine Oxidase 抗体 (A-3) 参考文献:

  1. 用于治疗痛风的一些中药植物对黄嘌呤氧化酶的抑制作用。  |  Kong, LD., et al. 2000. J Ethnopharmacol. 73: 199-207. PMID: 11025157
  2. 人类肝病中的血清黄嘌呤氧化酶。  |  Battelli, MG., et al. 2001. Am J Gastroenterol. 96: 1194-9. PMID: 11316169
  3. 发现黄嘌呤氧化酶抑制剂的进展。  |  Borges, F., et al. 2002. Curr Med Chem. 9: 195-217. PMID: 11860355
  4. 黄嘌呤氧化酶抑制剂和败血症。  |  Ramos, MFP., et al. 2018. Int J Immunopathol Pharmacol. 32: 2058738418772210. PMID: 29786457
  5. 痛风、黄嘌呤氧化酶抑制与心血管预后  |  White, WB. 2018. Circulation. 138: 1127-1129. PMID: 30354393
  6. 黄嘌呤氧化酶抑制剂对高尿酸血症患者的临床效果。  |  Cicero, AFG., et al. 2021. Med Princ Pract. 30: 122-130. PMID: 33040063
  7. 黄嘌呤氧化酶抑制剂用于预防心血管疾病。  |  Tanaka, A. and Node, K. 2022. Lancet. 400: 1172-1173. PMID: 36215992
  8. 黄嘌呤氧化酶抑制剂的最新进展。  |  Sun, ZG., et al. 2024. Mini Rev Med Chem. 24: 1177-1186. PMID: 37711003
  9. 黄嘌呤氧化酶抑制剂治疗或停药对死亡率的影响:黄嘌呤氧化酶抑制剂戒断综合征的证据。  |  Kuwabara, M., et al. 2023. Front Pharmacol. 14: 1289386. PMID: 38259292
  10. 人类黄嘌呤脱氢酶(XDH)基因位于染色体 2q22 上。  |  Rytkönen, EM., et al. 1995. Cytogenet Cell Genet. 68: 61-3. PMID: 7956361
  11. 人类胎盘中存在黄嘌呤氧化酶/脱氢酶。  |  Many, A., et al. 1996. Placenta. 17: 361-5. PMID: 8829220
  12. 分娩过程中黄嘌呤氧化酶的增加--对氧化应激的影响。  |  Many, A. and Roberts, JM. 1997. Placenta. 18: 725-6. PMID: 9364609

订购信息

产品名称产品编号规格价格数量收藏夹

Xanthine Oxidase 抗体 (A-3)

sc-398548
200 µg/ml
$316.00

Xanthine Oxidase (A-3): m-IgG Fc BP-HRP 套装

sc-530841
200 µg Ab; 10 µg BP
$354.00

Xanthine Oxidase (A-3): m-IgGκ BP-HRP 套装

sc-524387
200 µg Ab, 40 µg BP
$354.00

Xanthine Oxidase (A-3): m-IgG2a BP-HRP 套装

sc-547608
200 µg Ab; 10 µg BP
$354.00

Xanthine Oxidase 抗体 (A-3) AC

sc-398548 AC
500 µg/ml, 25% agarose
$416.00

Xanthine Oxidase 抗体 (A-3) HRP

sc-398548 HRP
200 µg/ml
$316.00

Xanthine Oxidase 抗体 (A-3) FITC

sc-398548 FITC
200 µg/ml
$330.00

Xanthine Oxidase 抗体 (A-3) PE

sc-398548 PE
200 µg/ml
$343.00

Xanthine Oxidase 抗体 (A-3) Alexa Fluor® 488

sc-398548 AF488
200 µg/ml
$357.00

Xanthine Oxidase 抗体 (A-3) Alexa Fluor® 546

sc-398548 AF546
200 µg/ml
$357.00

Xanthine Oxidase 抗体 (A-3) Alexa Fluor® 594

sc-398548 AF594
200 µg/ml
$357.00

Xanthine Oxidase 抗体 (A-3) Alexa Fluor® 647

sc-398548 AF647
200 µg/ml
$357.00

Xanthine Oxidase 抗体 (A-3) Alexa Fluor® 680

sc-398548 AF680
200 µg/ml
$357.00

Xanthine Oxidase 抗体 (A-3) Alexa Fluor® 790

sc-398548 AF790
200 µg/ml
$357.00

I am using Xanthine Oxidase (A-3): sc-398548 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: AbPolly
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Good for Western Blot!I used this antibody a few days ago. It works well in Western Blot!
Date published: 2022-11-21
Rated 5 out of 5 by from XDH antibodyWe use this one for western blot and it is a very nice one!
Date published: 2019-06-18
Rated 5 out of 5 by from Works Great!Got the bands at 145 kD which is the correct size..
Date published: 2017-09-26
Rated 5 out of 5 by from good choice for WBI used this antibody in western blot and got a positive band, it's a good choice for WB
Date published: 2017-08-26
Rated 4 out of 5 by from Works good without background!Tried the XO antibody and worked good at 1:50 dilution on Rat Corneal Epithelium. Positive labeling specific to some cells in our experimental tissues. Antigen retrieval by Protease K, XXII from Sigma.
Date published: 2017-07-21
Rated 5 out of 5 by from good antibody for western blotThis antibody works great for western blot in mouse liver: a single band at the predicted size.
Date published: 2017-06-22
Rated 5 out of 5 by from Excellent!This antibody works great in western blot analysis of Xanthine Oxidase expression in c4 whole cell lysate.
Date published: 2017-02-01
Rated 5 out of 5 by from Very good Western blot data of Xanthine OxidaseVery good Western blot data of Xanthine Oxidase expression in c4 whole cell lysate. -SCBT QC
Date published: 2013-04-09
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Xanthine Oxidase 抗体 (A-3) is rated 4.8 out of 5 by 8.
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