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VZV gE 抗体 (9C8): sc-56995

4.7(3)
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说明书
  • VZV gE 抗体 9C8 是小鼠单克隆 IgG1 κ，VZV gE抗体, 在12篇文献中引用，规格为100 µg/ml
  • 接种感染细胞提取物
  • 推荐用于 Varicella Zoster Virus 来源的glycoprotein E WB 和 IF检测
  • 关于如何获取VZV gE (9C8): sc-56995的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是VZV gE Antibody (9C8) for WB applications. 的首选辅助检测试剂，这些试剂现与VZV gE Antibody (9C8) 打包提供（请参阅下面的订购信息）。

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研究信息

関連項目

额外VZV抗体，包括VZV gB, VZV gE, VZV gH, VZV gI, VZV Immediate Early Protein, VZV Major Capsid Protein和VZV NC

VZV gE抗体（9C8）是一种IgG1 κ小鼠单克隆VZV gE抗体（也称为VZV gE抗体），可通过WB和IF检测水痘带状疱疹病毒来源的VZV gE蛋白。VZV gE抗体（9C8）可作为非偶联抗VZV gE抗体提供。水痘带状疱疹病毒（VZV），也称为人类疱疹病毒3型（HHV-3），与两种不同的疾病相关：儿童水痘和带状疱疹。VZV在感觉神经节中潜伏，可能在几十年后重新激活，产生带状疱疹或疱疹带状疱疹。VZV被包裹在反式高尔基体网络（TGN）中。在TGN中，糖蛋白I（gI）对于VZV的包膜和在VZV复制过程中有效的膜融合是必需的。gI的C端结构域需要将病毒和细胞蛋白分隔在包膜TGN小泡中。成熟gI的氨基末端需要通过VZV gE和gI的外部结构域形成糖蛋白E（gE）-gI复合物。gE是病毒体包膜的主要成分，可以在被感染的宿主细胞表面与糖蛋白I形成复合物。gE的表达由IE4和IE62激活。VZV gI对于病毒在Vero细胞中的复制、病毒在非人类细胞中的有效复制以及gE的正常加工都是必需的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

VZV gE 抗体 (9C8) 参考文献:

  1. 转录因子 Sp1 参与了水痘-带状疱疹病毒糖蛋白 E 的调控。  |  Rahaus, M. and Wolff, MH. 2000. Virus Res. 69: 69-81. PMID: 10989187
  2. 糖蛋白 I 的 C 端结构域在水痘-带状疱疹病毒在跨高尔基网络中的包膜过程中发挥的重要作用：糖蛋白与保护膜的相互作用。  |  Wang, ZH., et al. 2001. J Virol. 75: 323-40. PMID: 11119602
  3. 神经系统水痘-带状疱疹病毒感染：临床和病理相关性。  |  Kleinschmidt-DeMasters, BK. and Gilden, DH. 2001. Arch Pathol Lab Med. 125: 770-80. PMID: 11371229
  4. 水痘带状疱疹病毒糖蛋白 E（gE）对病毒复制的要求以及糖蛋白 I 对黑色素瘤细胞中 gE 的影响。  |  Mo, C., et al. 2002. Virology. 304: 176-86. PMID: 12504560
  5. 突变型 HNRNPA1 与水痘带状疱疹病毒 gE 在多发性硬化症发病机制中的复杂相互作用  |  Kattimani, Y. and Veerappa, AM. 2018. Autoimmunity. 51: 147-151. PMID: 29996671
  6. 水痘-带状疱疹病毒感染的人神经元对凋亡具有抵抗力。  |  Kennedy, PG., et al. 2020. J Neurovirol. 26: 330-337. PMID: 32125664
  7. 带状疱疹减毒活疫苗和重组疫苗的抗体反应比较。  |  Schmid, DS., et al. 2021. J Virol. 95: PMID: 33762414
  8. 水痘带状疱疹病毒糖蛋白 E 促进 PINK1/Parkin 介导的有丝分裂以逃避 STING 和 MAVS 介导的抗病毒先天性免疫  |  Oh, SJ., et al. 2024. Cell Death Dis. 15: 16. PMID: 38184594
  9. 水痘带状疱疹病毒糖蛋白 E 的结构和疫苗诱导抗体的表位图。  |  Harshbarger, WD., et al. 2024. Vaccines (Basel). 12: PMID: 39460278
  10. 在昆虫细胞中表达的水痘-带状疱疹病毒糖蛋白 E 和 I 形成了一个异源二聚体，需要糖蛋白 I 的 N 端结构域。  |  Kimura, H., et al. 1997. Virology. 233: 382-91. PMID: 9217061
  11. 水痘-带状疱疹病毒糖蛋白 I 对病毒在 Vero 细胞中的生长至关重要。  |  Cohen, JI. and Nguyen, H. 1997. J Virol. 71: 6913-20. PMID: 9261418
  12. 糖蛋白 I 在水痘-带状疱疹病毒复制中的作用及其对糖蛋白 E 构象和贩运的影响的突变分析。  |  Mallory, S., et al. 1997. J Virol. 71: 8279-88. PMID: 9343180

订购信息

产品名称产品编号规格价格数量收藏夹

VZV gE 抗体 (9C8)

sc-56995
100 µg/ml
RMB2377.00

VZV gE (9C8): m-IgG Fc BP-HRP 套装

sc-539048
100 µg Ab; 10 µg BP
RMB2662.00

VZV gE (9C8): m-IgG1 BP-HRP 套装

sc-541227
100 µg Ab; 20 µg BP
RMB2662.00

Hi, Would it be possible to obtain a biotinylated version of the following antibodies: sc-56995 and sc-56997? Thanks

Asked by: Anonymous
Thank you for your question. At this time, we are unable to provide a biotinylated version.
Answered by: BlakeJ
Date published: 2025-04-24

Hi,I use this product(VZV gE 9C8,sc-56995) and Goat anti-mouse IgG (H+L)-HRP conjugate (Bio-rad，cat：1706515）to do a Western-blot experiment, it doesn’t work. It used to work. I just don’t know why. If you know the reason, please  contact me.Thanks a lot!

Asked by: sklearn
Thank you for contacting Santa Cruz Biotechnology. For assistance please contact Technical service. Please call 800-457-3801 or email [email protected].
Answered by: BlakeJ
Date published: 2025-04-16

What is the type of specimens use to detection the herpse zoster  glycoprotein e by if 

Asked by: Shaimaa
Thank you for your question. This antibody can detect Varizella Zoster gE in infected cell lysates, extracts or supernatant.
Answered by: Tech Support Europe
Date published: 2024-05-15

Can this antibody be used for FACS analysis with a fluorescently labeled secondary antibody?

Asked by: Naeko
Thank you for your question.recommended for detection of glycoprotein E of Varicella Zoster Virus origin by WB and IF.Not recommended for FCM.Thank you.
Answered by: Jiajun Z
Date published: 2024-01-23

Has an epitope mapping been done on that antibody. I'm looking for antibodies targeting specific areas of gE Thanks

Asked by: Dorian
Thank you for your question. As of yet, no epitope mapping has been performed for Anti-VZV gE Antibody (9C8): sc-56995. We do not have information what its exact binding site is.
Answered by: Tech Support Europe
Date published: 2022-09-05

Wether the Ab can be used to ELISA? What's the dilution?

Asked by: vita2022
感谢您的提问。 这支抗体不推荐用于ELISA实验，谢谢。 您可在对应产品页面查询到此抗体适用的实验方法，谢谢！ Thank you for your question. This antibody is not recommended for ELISA. You can check related information on our official website.
Answered by: Ling Chen
Date published: 2022-06-09

what is the dilution factor in WB study? Thanks

Asked by: JohnW
Thank you for your question. The recommended starting dilution for this antibody in Western Blot is 1:200, within the range 1:100-1:2000. Here is a link to the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting If you have any further questions, please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2017-02-23

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-04
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Rated 5 out of 5 by from 很好用已经多次购买了 好用，每年都买几个，条带很特异，已经多次购买了 好用，每年都买几个，条带很特异，已经多次购买了 好用，每年都买几个，条带很特异。
Date published: 2021-12-21
Rated 5 out of 5 by from Great antibodyRecently cited in publications for WB, IF and IHC (P)
Date published: 2017-01-10
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VZV gE 抗体 (9C8) is rated 4.7 out of 5 by 3.
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