VEGFR2 Kinase Inhibitor III (CAS 204005-46-9)

物理状态 :

Solid

溶解度 :

Soluble in DMSO (5 mg/ml), and ethanol (100 mM). Insoluble in water.

保存 :

Store at 4° C

熔点 :

221-222° C

沸点 :

481.41° C at 760 mmHg (Predicted)

密度 :

1.26 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.68 (Predicted)

IC50 :

proliferation of HUVEC₅₀s induced by VEGF: IC₅₀ = 50 nM; autophosphorylation of internal tandem duplication: IC₅₀ = 0.1 µM; autophosphorylation of wild type Fms-like tyrosine kinase 3: IC₅₀ = 0.1 µM; VEGF-R: IC₅₀ = 1.04 µM (NIH 3T3 cells overexpressing Flk-1); Oxytocin-R: EC₅₀50 = 11.47 µM (human); AVP Receptor V1a: EC₅₀50 = 12.07 µM (human); PDGF-R tyrosine kinases: IC₅₀ = 20 µM (NIH 3T3 cells overexpressing Flk-1); proliferation of HUVEC₅₀s induced by EC₅₀GS: IC₅₀ = 30.5 µM; proliferation of HUVEC₅₀s induced by bFGF: IC₅₀ = 5.3 µM

pK值 :

pK_a: 13.18 (Predicted), pK_b: 1.53 (Predicted)

德国水公害等级 :

3

PubChem CID :

MDL 号码 :

MFCD01940922

SMILES :

CC1=CC(=C(N1)/C=C\\2/C3=CC=CC=C3NC2=O)C