Date published: 2025-9-6

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VEGF-D 抗体 (C-12): sc-373866

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说明书
  • VEGF-D 抗体 C-12 是小鼠单克隆 IgG1 κ,VEGF-D抗体, 在8篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的VEGF-D的C-terminus的氨基酸330-353之间
  • VEGF-D 抗体 (C-12) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 precursor VEGF-D
  • 抗VEGF-D抗体(C-12)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取VEGF-D (C-12): sc-373866免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是VEGF-D Antibody (C-12) for WB applications. 的首选辅助检测试剂,这些试剂现与VEGF-D Antibody (C-12) 打包提供(请参阅下面的订购信息)。

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関連項目

VEGF-D抗体(C-12)是一种IgG1 κ小鼠单克隆VEGF-D抗体(也称为FIGF抗体),可通过WB、IP、IF和ELISA检测人源VEGF-D蛋白。VEGF-D抗体(C-12)既可以是非偶联的抗VEGF-D抗体形式,也可以是多种偶联形式的抗VEGF-D抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。血管生成的发生被认为是肿瘤发生的早期事件,可能促进肿瘤进展和转移。已经描述了具有血管生成活性的几种生长因子。这些包括成纤维细胞生长因子(FGF)、血小板衍生生长因子(PDGF)和血管内皮生长因子(VEGF)。已经鉴定出几种形式的VEGF,包括VEGF、VEGF-B、VEGF-C和VEGF-D(也称为FIGF)。VEGF蛋白的特征是,VEGF-D的中央区域含有八个半胱氨酸残基。这些残基对于同源二聚化是必需的。VEGF-D可能在肿瘤进展中发挥作用,因为它是由c-Fos诱导的,c-Fos是将早期肿瘤转化为恶性肿瘤所必需的。已经观察到,VEGF-D的过度表达会诱导成纤维细胞的形态变化。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

VEGF-D 抗体 (C-12) 参考文献:

  1. 肿瘤血管生成:癌基因和抑癌基因的作用。  |  Bouck, N. 1990. Cancer Cells. 2: 179-85. PMID: 1696827
  2. 血管内皮生长因子多肽家族。  |  Ferrara, N., et al. 1991. J Cell Biochem. 47: 211-8. PMID: 1791185
  3. 血管生成因子。  |  Folkman, J. and Klagsbrun, M. 1987. Science. 235: 442-7. PMID: 2432664
  4. 在增生向肿瘤过渡期间诱导血管生成。  |  Folkman, J., et al. 1989. Nature. 339: 58-61. PMID: 2469964
  5. 提高 VEGF-D 作为雷莫芦单抗在转移性结直肠癌患者中的预测性生物标记物的重要性。  |  Carmeliet, P., et al. 2018. Ann Oncol. 29: 527-529. PMID: 29360914
  6. 不同等级子宫内膜癌中VEGF-C、VEGF-D和VEGFR-3的表达谱。  |  Oplawski, M., et al. 2019. Curr Pharm Biotechnol. 20: 1004-1010. PMID: 31333122
  7. 提高 VEGF-D 作为雷莫芦单抗在转移性结直肠癌患者中的预测性生物标记物的重要性。  |  Carmeliet, P., et al. 2018. Ann Oncol. 29: 529-532. PMID: 32139029
  8. 预测疑似或已知冠状动脉疾病患者死亡率的 VEGF-D 和 VEGF-C 的不同特征。  |  Wada, H., et al. 2020. J Am Heart Assoc. 9: e015761. PMID: 32319336
  9. 肌腱细胞中 VEGF-D 介导的信号传导参与了退化过程。  |  Tempfer, H., et al. 2022. FASEB J. 36: e22126. PMID: 35044682
  10. S100A6通过激活RAGE/NF-kB/VEGF-D途径驱动肝癌淋巴转移  |  Chen, T., et al. 2024. Cancer Lett. 587: 216709. PMID: 38350547
  11. 鉴定与血小板衍生物生长因子/血管内皮生长因子家族有关的 c-fos 诱导基因。  |  Orlandini, M., et al. 1996. Proc Natl Acad Sci U S A. 93: 11675-80. PMID: 8876195
  12. 新型血管内皮生长因子 VEGF-D 的分子克隆。  |  Yamada, Y., et al. 1997. Genomics. 42: 483-8. PMID: 9205122

订购信息

产品名称产品编号规格价格数量收藏夹

VEGF-D 抗体 (C-12)

sc-373866
200 µg/ml
RMB2377.00

VEGF-D (C-12): m-IgG Fc BP-HRP 套装

sc-527420
200 µg Ab; 10 µg BP
RMB2662.00

VEGF-D (C-12): m-IgG1 BP-HRP 套装

sc-532793
200 µg Ab; 20 µg BP
RMB2662.00

VEGF-D 抗体 (C-12) AC

sc-373866 AC
500 µg/ml, 25% agarose
RMB3129.00

VEGF-D 抗体 (C-12) HRP

sc-373866 HRP
200 µg/ml
RMB2377.00

VEGF-D 抗体 (C-12) FITC

sc-373866 FITC
200 µg/ml
RMB2482.00

VEGF-D 抗体 (C-12) PE

sc-373866 PE
200 µg/ml
RMB2580.00

VEGF-D 抗体 (C-12) Alexa Fluor® 488

sc-373866 AF488
200 µg/ml
RMB2685.00

VEGF-D 抗体 (C-12) Alexa Fluor® 546

sc-373866 AF546
200 µg/ml
RMB2685.00

VEGF-D 抗体 (C-12) Alexa Fluor® 594

sc-373866 AF594
200 µg/ml
RMB2685.00

VEGF-D 抗体 (C-12) Alexa Fluor® 647

sc-373866 AF647
200 µg/ml
RMB2685.00

VEGF-D 抗体 (C-12) Alexa Fluor® 680

sc-373866 AF680
200 µg/ml
RMB2685.00

VEGF-D 抗体 (C-12) Alexa Fluor® 790

sc-373866 AF790
200 µg/ml
RMB2685.00

VEGF-D (C-12) 中和勝肽

sc-373866 P
100 µg/0.5 ml
RMB511.00

Can I use this antibody for detection of VEGFD of mouse cell lines ?

Asked by: kidarime
Thank you for your question. This antibody is only recommended for human samples, it has not been tested for mouse cells so we are unable to warranty it for that use. Please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com if you have any further questions or if you would like to try a sample of this antibody.
Answered by: Tech Service
Date published: 2017-09-13

What application is the blocking peptide sc-373866 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
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Rated 4 out of 5 by from works with mouse epithelial cellsI tested free sample antibody for western blot with mouse cell line, could see the band for VEGFD around 40kda and 33kda as well in 12% PAGE.
Date published: 2017-10-18
Rated 5 out of 5 by from great featuresStrip is very noticeable, quality is very good,thank you
Date published: 2017-09-05
Rated 5 out of 5 by from Clean background and specific band by WBClean background and specific band by WB in human VEGF-D transfected 293T whole cell lysates. -SCBT QC
Date published: 2014-10-06
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VEGF-D 抗体 (C-12) is rated 4.7 out of 5 by 3.
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