Date published: 2026-10-24

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VEGF-C 抗体 (30AT1174.77.260): sc-130289

5.0(2)
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说明书
  • VEGF-C 抗体 30AT1174.77.260 是小鼠单克隆 IgG1, 在2篇文献中引用,提供 100 µg/ml
  • 培养自human来源的VEGF-CN-端的,中间的以及C-端的多肽
  • 推荐用于 mouse, rat 和 human 来源的VEGF-C WB, IP 和 ELISA检测
  • 看 VEGF-C (E-6): sc-374628,可查看有标记的 VEGF-C 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成VEGF-C 抗体 (30AT1174.77.260)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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血管生成的开始被认为是肿瘤发生的早期事件,可能促进肿瘤进展和转移。已经描述了几种具有血管生成活性的生长因子。这些包括成纤维细胞生长因子(FGF)、血小板衍生生长因子(PDGF)和血管内皮生长因子(VEGF)。 VEGF是一种二聚糖蛋白,与PDGF具有结构同源性。已经描述了通过选择性mRNA剪接产生的几种VEGF变体。据推测,VEGF可能在体内作为肿瘤血管生成因子发挥作用。另外两种蛋白质,称为VEGF-B和VEGF-C,与VEGF具有显著同源性。 VEGF-B在心脏和骨骼肌中大量表达,经常与VEGF共表达。 VEGF-C结合并特异性激活Flt-4和Flk-1。编码VEGF-B和VEGF-C的基因分别定位于染色体11q13.1和4q34.3。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

VEGF-C 抗体 (30AT1174.77.260) 参考文献:

  1. VEGF-B和VEGF-C的当前生物学。  |  Olofsson, B., et al. 1999. Curr Opin Biotechnol. 10: 528-35. PMID: 10600689
  2. VEGF-C/VEGFRs轴在肿瘤进展和治疗中的作用。  |  Chen, JC., et al. 2012. Int J Mol Sci. 14: 88-107. PMID: 23344023
  3. 成人神经干细胞中的细胞自主Vegf-C/Vegfr3信号传导。  |  Kang, TH., et al. 2015. Oncotarget. 6: 39387-8. PMID: 26575019
  4. 通过抑制 KRAS/YAP1 信号转导,靶向 VEGF-C/VEGFR3 轴抑制 Slug 介导的癌症转移和干性。  |  Yeh, YW., et al. 2017. Oncotarget. 8: 5603-5618. PMID: 27901498
  5. TGF-β⁻VEGF-C通路在纤维化相关淋巴管生成中的作用。  |  Kinashi, H., et al. 2018. Int J Mol Sci. 19: PMID: 30142879
  6. VEGF-C减轻盐敏感型高血压的肾损伤。  |  Beaini, S., et al. 2019. J Cell Physiol. 234: 9616-9630. PMID: 30378108
  7. 尼古丁介导的OTUD3下调抑制VEGF-C mRNA降解,促进人类食管癌的淋巴转移。  |  Wang, M., et al. 2021. Nat Commun. 12: 7006. PMID: 34853315
  8. 重组VEGF-C(Cys156Ser)可改善实验性肝硬化中的肠系膜淋巴引流和肠道免疫监视。  |  Juneja, P., et al. 2023. JHEP Rep. 5: 100816. PMID: 37663117
  9. 血浆NRP2和VEGF-C水平与前列腺癌疾病严重程度的关系。  |  Mullen, SA., et al. 2024. Prostate. 84: 277-284. PMID: 37942701
  10. miR-455-3p通过调节VEGF-C/VEGFR3来调节矽肺的淋巴管生成。  |  He, H., et al. 2024. Ecotoxicol Environ Saf. 278: 116444. PMID: 38728943

订购信息

产品名称产品编号规格价格数量收藏夹

VEGF-C 抗体 (30AT1174.77.260)

sc-130289
100 µg/ml
CNY2422.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with VEGF-C (30AT1174.77.260): sc-130289 antibody?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by JT from The antibody works well for Western blottingThe antibody works well for Western blotting detecting endogenous VEGF-C from HDMEC whole cell lysates. -SCBT QC
Date published: 2015-04-08
Rated 5 out of 5 by BO from Good signal strength in MCF7 whole cell lysatesGood signal strength in MCF7 whole cell lysates. -SCBT QC
Date published: 2014-08-12
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VEGF-C 抗体 (30AT1174.77.260) is rated 5.0 out of 5 by 2.
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