Date published: 2025-9-8

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VCP 抗体 (G-8): sc-374055

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说明书
  • VCP抗体(G-8)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的VCP的C-terminus附近的氨基酸760-797之间
  • 推荐用于 mouse, rat 和 human 来源的VCP WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • m-IgG Fc BP-HRP 是 VCP 抗体 (G-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与VCP 抗体 (G-8) 组合成套装提供。 (请参阅下面的订购信息)。

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    関連項目

    含缬氨酸蛋白(VCP),也称为TERA(过渡内质网ATP酶)或p97,是AAA ATP酶家族的成员,参与多种细胞活动。 VCP是酿酒酵母Cdc48的哺乳动物同源物,酿酒酵母Cdc48是酵母细胞有丝分裂完成所必需的蛋白质。 VCP被认为参与多种膜功能和细胞周期的调节。它与泛素化的IκB-α以及26S蛋白体结合,表明VCP在蛋白体介导的IκB-α降解中可能起作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    VCP 抗体 (G-8) 参考文献:

    1. 含缬氨酸蛋白(VCP)是自噬所必需的,在 VCP 疾病中会被破坏。  |  Ju, JS., et al. 2009. J Cell Biol. 187: 875-88. PMID: 20008565
    2. 含缬氨酸蛋白(VCP)在异常蛋白积累和转录物抑制之间的新型反馈机制。  |  Koike, M., et al. 2010. J Biol Chem. 285: 21736-49. PMID: 20410307
    3. 含缬氨酸蛋白(VCP/p97)是野生型共济失调素-3 的激活剂。  |  Laço, MN., et al. 2012. PLoS One. 7: e43563. PMID: 22970133
    4. 含缬氨酸蛋白(VCP/p97)的表达与HPV阴性口咽鳞状细胞癌(OSCC)的预后有关。  |  Meyer, MF., et al. 2014. PLoS One. 9: e114170. PMID: 25463965
    5. 含缬氨酸蛋白是压力过载诱导心肌细胞肥大的新型抑制因子。  |  Zhou, N., et al. 2017. Aging Cell. 16: 1168-1179. PMID: 28799247
    6. 含缬氨酸蛋白介导角鲨烯单加氧酶及其胆固醇反应降解子的ERAD。  |  Chua, NK., et al. 2019. Biochem J. 476: 2545-2560. PMID: 31471528
    7. 测量含缬氨苷蛋白/p97 的 ATPase 活性。  |  Suvarna, K., et al. 2020. Bio Protoc. 10: e3516. PMID: 33654741
    8. 靶向 VCP 可增强结直肠癌的免疫检查点疗法。  |  Wang, F., et al. 2023. Cell Rep. 42: 113318. PMID: 37865914
    9. TNF-α诱导的KAT2A通过介导有丝分裂相关蛋白VCP的琥珀酰化阻碍BMMSC的凋亡  |  Su, Z., et al. 2024. Adv Sci (Weinh). 11: e2303388. PMID: 38145956
    10. ATPase Valosin-Containing Protein (VCP) 参与了小脑脊髓灰质炎病毒(SDAV)在神经元中的复制和排出。  |  Bartak, M., et al. 2024. Int J Mol Sci. 25: PMID: 39519185

    订购信息

    产品名称产品编号规格价格数量收藏夹

    VCP 抗体 (G-8)

    sc-374055
    200 µg/ml
    RMB2377.00

    VCP (G-8): m-IgG Fc BP-HRP 套装

    sc-540418
    200 µg Ab; 10 µg BP
    RMB2662.00

    VCP (G-8) 中和勝肽

    sc-374055 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-374055 P appropriate for?

    Asked by: jerojero
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 5 out of 5 by from Produced superb immunoperoxidase nuclearProduced superb immunoperoxidase nuclear and cytoplasmic staining in formalin fixed, paraffin-embedded human esophagus tissue. -SCBT QC
    Date published: 2015-03-26
    Rated 5 out of 5 by from Satisfactory Western Blot data of VCP expressionSatisfactory Western Blot data of VCP expression in non-transfected and human VCP transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-12-14
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    VCP 抗体 (G-8) is rated 5.0 out of 5 by 2.
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