Vatalanib Dihydrochloride (CAS 212141-51-0)

物理状态 :

Solid

溶解度 :

Soluble in DMSO (30 mg/mL), ethanol (10 mg/mL) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/mL ).

保存 :

Store at -20° C

熔点 :

244-246° C

IC50 :

VEGF receptor/KDR: IC₅₀ = 37 nM; VEGF receptor/Flt-1: IC₅₀ = 77 nM; VEGF receptor/Flk: IC₅₀ = 270 nM; c-Kit: IC₅₀ = 730 nM; PDGFR-β: IC₅₀ = 580 nM; VEGF-induced phosphorylation: IC₅₀ = 17 nM (HUVEC₅₀s cells); VEGF-induced phosphorylation: IC₅₀ = 34 nM (CHO cells); Thymidine incorporation induced by VEGF: IC₅₀ = 1.7 nM (HUVEC₅₀s)

PubChem CID :

SMILES :

C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl