Ursodeoxycholic Acid, Sodium Salt CAS: 2898-95-5
MF: C24H39NaO4
MW: 414.55

Ursodeoxycholic Acid, Sodium Salt (CAS 2898-95-5)

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Alternate Names: Ursodeoxycholic Acid, Sodium Salt is also known as UDCA.
Application: Ursodeoxycholic Acid, Sodium Salt is a steroid which reduces hydrophobic bile acids and inhibits taurocholic acid uptake in HeLa cells.
CAS Number: 2898-95-5
Purity: ≥98%
Molecular Weight: 414.55
Molecular Formula: C24H39NaO4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Ursodeoxycholic Acid, Sodium Salt is a steroid and secondary bile acid formed via epimerization of chenodeoxycholic acid. Ursodeoxycholic Acid, Sodium Salt reduces hydrophobic bile acids. Ursodeoxycholic Acid, Sodium Salt also decreases lymphocyte reactivity and serum alkaline phosphatase levels when used in the treatment for primary biliary cirrhosis. Ursodeoxycholic Acid, Sodium Salt is also known as UDCA, Sodium Ursodeoxycholate, and (5β)-3α,7β-dihydroxy-cholan-24-oic acid, monosodium salt.


参考文献

1. Oh, A.R. et al. 2016. BMB Rep. 49(2): 105-110. PMID: 26350747

Physical State :
Solid
Solubility :
Soluble in water (200 mg/ml), ethanol (15 mg/ml), DMSO (10 mg/ml), and DMF (5 mg/ml).
Storage :
Store at room temperature
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20D 48.5, c = 2 in water
IC50 :
M1-family aminopeptidase: IC50 = 2.6 µM (Plasmodium falciparum 3D7); NTCP: IC50 = 3.6 µM (human); HCT-116: IC50 = >50 µM (human); GBM: IC50 = >50 µM (human)
Ki Data :
Asbt: Ki= 75 µM (human)
pK Values :
pKa: 4.76 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
23707110
Merck Index :
14: 9889
MDL Number :
MFCD00065453

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Citations 1 to 3 of 3 total

PMID: # 30767682  2019. Am. J. Physiol. Gastrointest. Liver Physiol. 316: G574-G584.

PMID: # 29351391  Mroz, MS.|Lajczak, NK.|Goggins, BJ.|Keely, S.|Keely, SJ.| et al. 2018. Am. J. Physiol. Gastrointest. Liver Physiol. 314: G378-G387.

PMID: # 26351365  Sousa, T. et al. 2015. Journal of lipid research. 56: 2158-71.

Citations 1 to 3 of 3 total
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