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UCP1 Antibody (4E5) - Western Blotting - Image 348871
UCP1 抗体 (4E5): sc-293418. 人重组 UCP1 融合蛋白的 Western 印迹分析.
UCP1 Antibody (4E5) - Western Blotting - Image 348871
UCP1 抗体 (4E5): sc-293418. 人重组 UCP1 融合蛋白的 Western 印迹分析.
UCP1 Antibody (4E5) - Western Blotting - Image 366613
UCP1 抗体 (4E5): sc-293418. A549 (A) 和 NIH/3T3 (B) 全细胞裂解液及人 PBL 组织提取物 (C) 中 UCP1 表达的 Western 印迹分析.
UCP1 抗体 (4E5): sc-293418. 人重组 UCP1 融合蛋白的 Western 印迹分析.

UCP1 抗体 (4E5): sc-293418

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寫評論提問

说明书
  • UCP1 抗体 4E5 是小鼠单克隆 IgG2a κ，UCP1抗体, 在25篇文献中引用，规格为100 µg/ml
  • 与氨基酸232-267结合，代表human起源的部分长度UCP1
  • 推荐用于 mouse, rat 和 human 来源的UCP1 WB, IP 和 ELISA检测
  • 关于如何获取UCP1 (4E5): sc-293418的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP是UCP1 Antibody (4E5) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与UCP1 Antibody (4E5) 搭配使用（请参阅下面的订购信息）。

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描述
基因信息
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研究信息

関連項目

额外UCP抗体，包括UCP1, UCP2和UCP4

UCP1抗体（4E5）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的UCP1蛋白。抗UCP1抗体（4E5）以非结合形式提供。UCP1，也称为SLC25A7，是一种膜结合蛋白，主要存在于棕色脂肪组织线粒体中，在产热过程中起着至关重要的作用。UCP1通过形成二聚体来发挥功能，该二聚体充当质子通道，允许质子在没有产生ATP的情况下重新进入线粒体基质，从而消除电化学梯度并产生热量。这个过程在寒冷环境中维持体温，并与能量消耗和葡萄糖代谢紧密相关。UCP1活性调节对于代谢健康至关重要，因为UCP1会影响能量储存和消耗之间的平衡，因此UCP1成为肥胖和代谢紊乱研究的重要目标。UCP2是一种相关的蛋白质，与UCP1具有相似的构造，在包括白色脂肪组织和肌肉在内的更广泛的组织中表达，这表明这些蛋白质在能量调节和体重管理方面存在复杂的相互作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

UCP1 抗体 (4E5) 参考文献:

  1. 线粒体解偶联蛋白 UCP2 介导的过氧化氢脂肪酸循环。  |  Jaburek, M., et al. 2004. J Biol Chem. 279: 53097-102. PMID: 15475368
  2. 异质核糖核蛋白 K 可增强胰岛素诱导的线粒体 UCP2 蛋白的表达。  |  Ostrowski, J., et al. 2004. J Biol Chem. 279: 54599-609. PMID: 15485813
  3. 过表达短异源二聚体伙伴可恢复过表达 UCP2 的胰腺β细胞在葡萄糖刺激下受损的胰岛素分泌。  |  Suh, YH., et al. 2004. J Endocrinol. 183: 133-44. PMID: 15525581
  4. 棕色脂肪组织产热：跨学科研究。  |  Himms-Hagen, J. 1990. FASEB J. 4: 2890-8. PMID: 2199286
  5. 人类解偶联蛋白基因：结构, 与大鼠基因的比较以及归属于第 4 号染色体长臂。  |  Cassard, AM., et al. 1990. J Cell Biochem. 43: 255-64. PMID: 2380264
  6. 小鼠棕色脂肪线粒体解偶联蛋白。分子克隆, 基因图谱和 mRNA 表达。  |  Jacobsson, A., et al. 1985. J Biol Chem. 260: 16250-4. PMID: 2999153
  7. 棕色和米色脂肪细胞中UCP1依赖性和非依赖性生热。  |  Ikeda, K. and Yamada, T. 2020. Front Endocrinol (Lausanne). 11: 498. PMID: 32849287
  8. AIDA 通过 UCP1 将交感神经支配与适应性产热直接联系起来。  |  Shi, M., et al. 2021. Nat Cell Biol. 23: 268-277. PMID: 33664495
  9. UCP1控制肝脏细胞外琥珀酸和炎症发病机制。  |  Mills, EL., et al. 2021. Nat Metab. 3: 604-617. PMID: 34002097
  10. UCP1和CKB对冷触发脂肪细胞生热的平行控制。  |  Rahbani, JF., et al. 2024. Cell Metab. 36: 526-540.e7. PMID: 38272036
  11. 棕色脂肪的生热机制  |  Nicholls, DG. and Locke, RM. 1984. Physiol Rev. 64: 1-64. PMID: 6320232
  12. 解偶联蛋白-2：与肥胖和高胰岛素血症有关的新基因。  |  Fleury, C., et al. 1997. Nat Genet. 15: 269-72. PMID: 9054939

订购信息

产品名称产品编号规格价格数量收藏夹

UCP1 抗体 (4E5)

sc-293418
100 µg/ml
RMB2377.00

UCP1 (4E5): m-IgG Fc BP-HRP 套装

sc-540289
100 µg Ab; 10 µg BP
RMB2662.00

UCP1 (4E5): sc-293418の無料の10 µgサンプルはどのようにして申し込めばよいのでしょうか。

Asked by: Sean
質問頂き、誠にありがとうございます。サンプルの申し込みは日本のディーラーを連絡し、お尋ねください。宜しくお願い致します。https://www.scbt.com/ja/resources/distributors?&_requestid=1655 Thank you very much for your question. Please contact your Japanese dealer and ask for a sample application. Best regards. https://www.scbt.com/ja/resources/distributors?&_requestid=1655
Answered by: Jiajun Z
Date published: 2023-12-25

I am interested the 10ug free sample of UCP1 antibody to check my cell model.

Asked by: Mohasin
Thank you very much for your inquiry. We don't have currently a limit in the samples we can send per order, would you, or any of your colleagues, like to try any other antibody? please let me know so we make a single shipment. Please let me know the following information: - complete address for shipping - telephone, fax number and e-mail address - a contact person the products should be addressed to - catalogue number and product description Remember once you try the sample, you can write a review in our web about it, indicating all the information you think might be useful for other researchers.
Answered by: Technical Support Europe
Date published: 2017-09-14

For Western Blot, is it recommended to use denatured or non-denatured conditions with UCP1 (4E5): sc-293418 antibody?

Asked by: Dr Ninau Qelp
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Resultados excelentesHe usado el anticuerpo tanto para tejido como para células de ratón y funciona correctamente
Date published: 2021-11-11
Rated 4 out of 5 by from Good quality for WBSamples: LLC and B16F10 (mouse cancer cell lines) w/ or w/o a treatment. Dilution: 1:100 in HIKARI sol. (Nacalai, Japan) Clear and fairly strong bands appeared around 30 kD.
Date published: 2021-04-05
Rated 4 out of 5 by from Additional bandsGood signal. There is an additional band in the BAT lysate.
Date published: 2018-07-24
Rated 4 out of 5 by from Very good on FFPE sampleWe used 1:100 dilution of this antibody on our slides, it worked well.
Date published: 2018-06-22
Rated 5 out of 5 by from Good, I use it to get a publish date.I ask for a sample,and i find the antibody great.
Date published: 2017-12-22
Rated 5 out of 5 by from it works for western blottingworked for western blotting. Samples were from mouse adipose and liver tissue. 3% BSA in PBST. 1:1000 dilution.
Date published: 2017-11-29
Rated 5 out of 5 by from great antibodyWe tried this antibody on western-blot of brow adipose tissue and it works very good
Date published: 2017-11-24
Rated 5 out of 5 by from The antibody worksAt a dilution of 1:500 in 5% milk, this antibody worked well for us and we were able to visualize the band
Date published: 2017-10-06
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UCP1 抗体 (4E5) is rated 4.6 out of 5 by 17.
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