Date published: 2025-9-8
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UCH-L1 Antibody (31A3) - Western Blotting - Image 356952
UCH-L1 抗体 (31A3): sc-58595. 在 SH-SY5Y (A), SK-N-SH (B), NCI-H292 (C), RIN-m5F (D), H19-7/IGF-IR (E) 和 PC-12 (F) 全细胞裂解液中 UCH-L1 表达的 Western 印迹分析.
UCH-L1 抗体 (31A3): sc-58595. 在 SH-SY5Y (A), SK-N-SH (B), NCI-H292 (C), RIN-m5F (D), H19-7/IGF-IR (E) 和 PC-12 (F) 全细胞裂解液中 UCH-L1 表达的 Western 印迹分析.

UCH-L1 抗体 (31A3): sc-58595

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说明书
  • UCH-L1抗体(31A3)是小鼠单克隆IgG1 κ, 在2篇文献中引用，规格为200 µg/ml
  • 针对human来源的天然UCH-L1
  • 推荐用于 mouse, rat 和 human 来源的UCH-L1 on neuronal cell bodies and axons in the CNS and periphery, small nerve fibers in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and tumors of the DNES WB, IP, IF 和 IHC(P)检测; 也和以下物种反应，包括： 和 bovine and porcine
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 UCH-L1 抗体 (31A3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与UCH-L1 抗体 (31A3) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 UCH-L 抗体包括 UCH-L1, UCH-L3 和 UCH-L5

UCH-L1（泛素C末端水解酶）是一个基因家族的成员，其产物将泛素的小C末端加合物水解为泛素单体。UCH-L1的表达对神经元和弥漫性神经内分泌系统的细胞及其肿瘤具有高度特异性。UCH-L1在脑神经元中表达。对特定脑区的检查显示在所有测试区域都有表达，特别是在黑质中。UCH-L1占可溶性脑蛋白总量的1-2%。它在路易体中的出现及其在蛋白酶体途径中的作用使其成为帕金森病中引人注目的候选基因。编码UCH-L1的基因定位于人类染色体4p13。230个氨基酸的人UCH-L3蛋白与UCH-L1的蛋白质有54%的同源性。UCH-L3是主要的巯基蛋白酶，对泛素具有高亲和力结合位点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

UCH-L1 抗体 (31A3) 参考文献:

  1. UCH-L1通过蛋白质积累诱导膜性肾病中的足细胞肥大。  |  Lohmann, F., et al. 2014. Biochim Biophys Acta. 1842: 945-58. PMID: 24583340
  2. UCH-L1抑制可降低Tau蛋白的微管结合功能。  |  Xie, M., et al. 2016. J Alzheimers Dis. 49: 353-63. PMID: 26444754
  3. 含 UCH-L1 的外泌体介导乳腺癌化疗耐药性转移  |  Ning, K., et al. 2017. J Surg Oncol. 115: 932-940. PMID: 28334432
  4. UCH-L1抑制蛋白酶体损伤过程中tau聚集体的形成。  |  Yu, Q., et al. 2018. Mol Neurobiol. 55: 3812-3821. PMID: 28540657
  5. UCH-L1通过激活Akt信号通路促进乳腺癌细胞的侵袭。  |  Luo, Y., et al. 2018. J Cell Biochem. 119: 691-700. PMID: 28636190
  6. 抑制 UCH-L1 会加重戊四唑点燃模型中苔藓纤维的萌发。  |  Wen, Y., et al. 2018. Biochem Biophys Res Commun. 503: 2312-2318. PMID: 29964011
  7. UCH-L1是多发性创伤后小鼠创伤性脑损伤的劣质血清生物标志物。  |  Morris, MC., et al. 2019. J Surg Res. 244: 63-68. PMID: 31279265
  8. 泛素C-末端水解酶-L1（UCH-L1）血清水平与认知和脑能量代谢的关系。  |  Zhang, M., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 3656-3663. PMID: 35647847
  9. 血液中UCH-L1和NfL水平与帕金森病患者认知功能障碍的关系。  |  Dong, L., et al. 2023. Neurosci Lett. 804: 137219. PMID: 37023526
  10. 血浆泛素C-末端水解酶-L1（UCH-L1）水平作为异基因造血细胞移植后神经系统损伤的血液生物标志物。  |  Okada, Y., et al. 2023. Int J Hematol. 118: 340-346. PMID: 37480445

订购信息

产品名称产品编号规格价格数量收藏夹

UCH-L1 抗体 (31A3)

sc-58595
200 µg/ml
RMB2377.00

UCH-L1 (31A3): m-IgG Fc BP-HRP 套装

sc-539087
200 µg Ab; 10 µg BP
RMB2662.00

UCH-L1 (31A3): m-IgG1 BP-HRP 套装

sc-541250
200 µg Ab; 20 µg BP
RMB2662.00

Are there any issues with using sc-58595: UCH-L1 (31A3) mouse monoclonal primary antibody on mouse samples?

Asked by: AbPolly
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-58595 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Produced strong positive band in WB in ratProduced strong positive band in WB in rat brain tissue extract. -SCBT QC
Date published: 2015-07-03
Rated 5 out of 5 by from ClearClear, crisp band of interest obtained in WB in IMR-32 whole cell lysate. -SCBT QC
Date published: 2015-06-07
Rated 5 out of 5 by from Published data for IF in mouse induced pluripotentPublished data for IF in mouse induced pluripotent stem cells (m-iPSC). -SCBT Publication Review
Date published: 2015-03-07
Rated 5 out of 5 by from Performed well in WB in human UCHPerformed well in WB in human UCH-L1 transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-02-23
Rated 5 out of 5 by from IF publishable data with mouse induced pluripotentIF publishable data with mouse induced pluripotent stem cells (m-iPSC) - SCBT Publication Review
Date published: 2013-06-03
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UCH-L1 抗体 (31A3) is rated 5.0 out of 5 by 5.
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