Date published: 2025-9-8
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UCH-L1 Antibody (13C4) - Western Blotting - Image 375598
UCH-L1 抗体 (13C4): sc-58594. T98G (A) 和 C6 (B) 全细胞裂解液以及人脑 (C), 人大脑皮层 (D) 和小鼠小脑 (E) 组织提取物中 UCH-L1 表达的 Western 印迹分析.
UCH-L1 抗体 (13C4): sc-58594. T98G (A) 和 C6 (B) 全细胞裂解液以及人脑 (C), 人大脑皮层 (D) 和小鼠小脑 (E) 组织提取物中 UCH-L1 表达的 Western 印迹分析.

UCH-L1 抗体 (13C4): sc-58594

4.8(6)
寫評論提問

说明书
  • UCH-L1抗体(13C4)是小鼠单克隆IgG2a κ, 在3篇文献中引用，规格为200 µg/ml
  • 针对human来源的天然UCH-L1蛋白
  • 推荐用于 mouse, rat 和 human 来源的UCH-L1 on neuronal cell bodies and axons in the CNS and periphery, small nerve fibers in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and tumors of the DNES WB, IP, IF 和 IHC(P)检测; 还建议用于检测UCH-L1 in human adult gut
  • m-IgGκ BP-HRP 是 UCH-L1 抗体 (13C4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与UCH-L1 抗体 (13C4) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品，请参阅我们的小鼠 IgG 结合蛋白完整列表。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 UCH-L 抗体包括 UCH-L1, UCH-L3 和 UCH-L5

UCH-L1（泛素C末端水解酶）是一个基因家族的成员，其产物将泛素的小C末端加合物水解为泛素单体。UCH-L1的表达对神经元和弥漫性神经内分泌系统的细胞及其肿瘤具有高度特异性。UCH-L1在脑神经元中表达。对特定脑区的检查显示在所有测试区域都有表达，特别是在黑质中。UCH-L1占可溶性脑蛋白总量的1-2%。它在路易体中的出现及其在蛋白酶体途径中的作用使其成为帕金森病中引人注目的候选基因。编码UCH-L1的基因定位于人类染色体4p13。230个氨基酸的人UCH-L3蛋白与UCH-L1的蛋白质有54%的同源性。UCH-L3是主要的巯基蛋白酶，对泛素具有高亲和力结合位点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

UCH-L1 抗体 (13C4) 参考文献:

  1. UCH-L1的功能及其与神经退行性疾病的关系。  |  Setsuie, R. and Wada, K. 2007. Neurochem Int. 51: 105-11. PMID: 17586089
  2. 帕金森病和神经退行性疾病中UCH-L1的家族性突变和翻译后修饰。  |  Lee, YC. and Hsu, SD. 2017. Curr Protein Pept Sci. 18: 733-745. PMID: 26899237
  3. 有轻度和无轻度创伤性脑损伤的大型创伤患者队列中胶质和神经元血液生物标志物 GFAP 和 UCH-L1 的时间过程和诊断准确性。  |  Papa, L., et al. 2016. JAMA Neurol. 73: 551-60. PMID: 27018834
  4. 泛素 C 端水解酶-L1（UCH-L1）作为神经变性, 神经创伤和神经损伤的治疗和诊断靶标。  |  Wang, KK., et al. 2017. Expert Opin Ther Targets. 21: 627-638. PMID: 28434268
  5. 泛素 C-终止子水解酶-L1（UCH-L1）在创伤性脑损伤计算机断层扫描结果预测中的作用；一项 Meta 分析。  |  Ramezani, F., et al. 2018. Emerg (Tehran). 6: e62. PMID: 30788389
  6. S100B、GFAP、UCH-L1和NSE作为轻度脑外伤后CT成像异常的预测因子：诊断测试准确性的系统评价和荟萃分析。  |  Amoo, M., et al. 2022. Neurosurg Rev. 45: 1171-1193. PMID: 34709508
  7. UCH-L1 和 UCH-L3 通过 PI3 K/Akt 信号通路调控前列腺癌细胞的癌症干细胞样特性。  |  Lee, JE., et al. 2021. Anim Cells Syst (Seoul). 25: 312-322. PMID: 34745437
  8. 美国 TRACK-TBI 队列中受伤当天血浆 GFAP 和 UCH-L1 浓度对预测创伤性脑损伤患者功能恢复的预后价值：一项观察性队列研究]。  |  Korley, FK., et al. 2022. Lancet Neurol. 21: 803-813. PMID: 35963263
  9. 功能失调的UCH-L1抑制蛋白质稳态。  |  Wang, M. 2023. Nat Rev Nephrol. 19: 424. PMID: 37258710
  10. 近距蛋白质组学揭示UCH-L1是NLRP3介导的人体巨噬细胞和小胶质细胞IL-1β产生的重要调节因子。  |  Liang, Z., et al. 2024. Cell Rep. 43: 114152. PMID: 38669140

订购信息

产品名称产品编号规格价格数量收藏夹

UCH-L1 抗体 (13C4)

sc-58594
200 µg/ml
RMB2377.00

UCH-L1 (13C4): m-IgGκ BP-HRP 套装

sc-521055
200 µg Ab, 40 µg BP
RMB2662.00

I could not find the immunogen sequence of this antibody, do you have this information?

Asked by: soso
Thank you for your question. The UCH-L1 Antibody is raised against native UCH-L1 protein of human origin. The exact immunogen sequence is considered proprietary.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

For Western Blot, is it recommended to use denatured or non-denatured conditions with UCH-L1 (13C4): sc-58594 monoclonal antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Western blot is good ！！！Western blot is good ！！！The experiment went well and saved me a lot of time！
Date published: 2017-10-31
Rated 4 out of 5 by from Good in IHCUsed in mouse tissue by IHC, good signal with some background
Date published: 2017-08-28
Rated 5 out of 5 by from Produced clearProduced clear, strong band of interest in WB in IMR-32, neuro-2a, PC-12 and SK-N-SH whole cell lysates and mouse brain tissue extract. -SCBT QC
Date published: 2015-07-04
Rated 5 out of 5 by from Performed well in WB in rat brain tissue extractPerformed well in WB in rat brain tissue extract. -SCBT QC
Date published: 2015-03-02
Rated 5 out of 5 by from Good antibody for WB in human UCHGood antibody for WB in human UCH-L1 transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-02-23
Rated 5 out of 5 by from StrongStrong, specific band observed in WB in IMR-32 whole cell lysate. -SCBT QC
Date published: 2014-08-06
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UCH-L1 抗体 (13C4) is rated 4.8 out of 5 by 6.
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