UBE1 负责泛素-蛋白质异肽键形成的第一步。UBE1 通过形成高能硫酯键催化泛素 C 端羧基的活化。活化后的泛素通过 E2/E3 连接级联转移到目标蛋白质的赖氨酸上。是启动体外共轭反应的关键成分。
Ubiquitin Activating Enzyme UBE1 (rabbit) 参考文献
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system: A. Ciechanover, et al.; PNAS 78, 761 (1981) Covalent affinity purification of ubiquitin-activating enzyme: A. Ciechanover, et al.; J. Biol. Chem. 257, 2537 (1982) The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis: A.L. Haas & I.A. Rose; J. Biol. Chem. 257, 10329 (1982)