Date published: 2025-9-8

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UBE2D2 抗体 (Y-20): sc-100617

5.0(4)
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说明书
  • UBE2D2 抗体 Y-20 是小鼠单克隆 IgG2a κ,UBE2D2抗体, 在3篇文献中引用,规格为100 µg/ml
  • 免疫human物种的重组UBE2D2
  • 推荐用于 mouse, rat 和 human 来源的UBE2D2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成UBE2D2 抗体 (Y-20)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

UBE2D2抗体(Y-20)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类源的UBE2D2蛋白。抗UBE2D2抗体(Y-20)可作为非结合形式提供。UBE2D2在泛素-蛋白酶体系统中起着至关重要的作用,该系统通过调节蛋白质降解来维持细胞内环境平衡。UBE2D2主要位于细胞质中,与各种E3连接酶相互作用,促进泛素化过程。UBE2D2在细胞质中的定位使其能够快速响应细胞应激,调节错误折叠或受损的蛋白质降解,防止潜在的毒性聚集。UBE2D2通过磷酸化并依赖SCFβ-TRCP的方式催化IκBα泛素化,其中E1首先将泛素转移到UBE2D2上,然后UBE2D2与E3连接酶结合,将多聚泛素链连接到目标蛋白上。这种标记过程对于IκBα通过蛋白酶体降解至关重要,随后NFκB才能转移到细胞核并激活与免疫和炎症反应相关的基因。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

UBE2D2 抗体 (Y-20) 参考文献:

  1. 鉴定 NEDD8 连接途径的激活酶和连接酶。  |  Gong, L. and Yeh, ET. 1999. J Biol Chem. 274: 12036-42. PMID: 10207026
  2. 热诱导的酿酒酵母细胞周期停滞:RAD6/UBC2 和 WSC2 基因参与了细胞周期停滞的逆转。  |  Raboy, B., et al. 1999. Mol Microbiol. 32: 729-39. PMID: 10361277
  3. SCF(β-TRCP)和 Ubc3 和 Ubc4 催化的 I kappa B alpha 的磷酸化依赖性泛素化。  |  Strack, P., et al. 2000. Oncogene. 19: 3529-36. PMID: 10918611
  4. MUL1-RING将底物p53-TAD作为UBE2D2-UB共轭物的复合物招募。  |  Lee, MS., et al. 2022. FEBS J. 289: 3568-3586. PMID: 35048531
  5. Circular RNA-UBE2D2通过调节microRNA-376a-3p/真核翻译起始因子4γ2轴,加速非小细胞肺癌细胞的增殖和转移。  |  Tong, J., et al. 2022. Bioengineered. 13: 5942-5953. PMID: 35196197
  6. Circ_UBE2D2通过靶向miR-370-3p/NR4A3轴,减轻大鼠脓毒性急性肾损伤的进展。  |  Huang, Y. and Zheng, G. 2022. J Microbiol Biotechnol. 32: 740-748. PMID: 35722711
  7. 泛癌中与铜蓝蛋白相关的基因UBE2D2作为免疫治疗和预后生物标志物发挥作用。  |  Fei, Y., et al. 2024. Clin Transl Oncol. 26: 2718-2737. PMID: 38703335
  8. 泛素, 蛋白酶体和细胞内蛋白质降解的调控。  |  Hochstrasser, M. 1995. Curr Opin Cell Biol. 7: 215-23. PMID: 7612274
  9. 泛素-蛋白酶体蛋白水解途径。  |  Ciechanover, A. 1994. Cell. 79: 13-21. PMID: 7923371
  10. 泛素介导的蛋白水解途径:识别蛋白水解底物和参与降解原生细胞蛋白的机制。  |  Ciechanover, A. and Schwartz, AL. 1994. FASEB J. 8: 182-91. PMID: 8119489
  11. 泛素样蛋白 SMT3 和 SUMO-1 由 UBC9 E2 酶结合。  |  Schwarz, SE., et al. 1998. Proc Natl Acad Sci U S A. 95: 560-4. PMID: 9435231
  12. 与泛素系统有关的新型蛋白质修饰途径。  |  Liakopoulos, D., et al. 1998. EMBO J. 17: 2208-14. PMID: 9545234

订购信息

产品名称产品编号规格价格数量收藏夹

UBE2D2 抗体 (Y-20)

sc-100617
100 µg/ml
$333.00

Can sc-100617: UBE2D2 (Y-20) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: TinTin
Thank you for your question. Yes, sc-100617: UBE2D2 (Y-20) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good choice for Western BlotThis antibody has been used for western blotting in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Strong positive band observed in WB in mouseStrong positive band observed in WB in mouse UBE2D2 transfected 293T whole cell lysate and rat testis tissue extract. -SCBT QC
Date published: 2015-06-28
Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded human small Intestine tissue. -SCBT QC
Date published: 2015-04-02
Rated 5 out of 5 by from ClearClear, specific band obtained in WB in NIH/3T3 whole cell lysate. -SCBT QC
Date published: 2015-01-15
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UBE2D2 抗体 (Y-20) is rated 5.0 out of 5 by 4.
  • y_2025, m_8, d_27, h_4
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