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TSHR Antibody (4C1) - Flow Cytometry - Image 135116
TSHR 抗体 (4C1) FITC: sc-32262 FITC. 固定和通透的 Hela 细胞的胞内 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG2a: sc-2856.
TSHR Antibody (4C1) - Flow Cytometry - Image 135116
TSHR 抗体 (4C1) FITC: sc-32262 FITC. 固定和通透的 Hela 细胞的胞内 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG2a: sc-2856.
TSHR Antibody (4C1) - Flow Cytometry - Image 9809
TSHR 抗体 (4C1) PE: sc-32262 PE. 固定和通透的 HeLa 细胞的胞内 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG2a: sc-2867.
TSHR Antibody (4C1) - Flow Cytometry - Image 12059
GPI-anchored TSHR 的间接 FCM 分析 (Da Costa CR, Johnstone AP. JBC, 1998 年). 红色阴影直方图代表对照小鼠 IgG. 蓝线直方图代表 TSHR (2C11), sc-32263. 绿色直方图代表 TSHR 抗体 (4C1), sc-32262. 由伦敦大学圣乔治学院 Alan Johnstone 博士友情提供.
TSHR 抗体 (4C1) FITC: sc-32262 FITC. 固定和通透的 Hela 细胞的胞内 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG2a: sc-2856.

TSHR 抗体 (4C1): sc-32262

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寫評論提問

说明书
  • TSHR抗体(4C1)是小鼠单克隆IgG2a κ, 在9篇文献中引用，规格为200 µg/ml
  • 针对human的TSHR的胞外结构域制备，表位图谱对应于氨基酸381-384
  • 推荐用于 human 来源的TSHR IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是TSHR Antibody (4C1). 的首选辅助检测试剂。这些试剂现与TSHR Antibody (4C1) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

TSHR抗体（4C1）是一种小鼠单克隆IgG2a抗体，可通过免疫沉淀（IP）、免疫荧光（IF）和流式细胞术（FCM）等方法检测人类样本中的促甲状腺激素受体（TSHR）。抗TSHR抗体（4C1）在甲状腺功能研究中起着至关重要的作用，因为TSHR是一种位于甲状腺细胞表面的糖蛋白受体，负责调节促甲状腺激素（TSH）的作用。TSH与TSHR结合后，会启动一系列细胞内信号传导，从而调节甲状腺激素的合成和释放，这对于维持体内代谢平衡至关重要。TSHR（4C1）单克隆抗体可用于研究各种生理过程，包括生长、发育和新陈代谢，因此TSHR成为了解甲状腺相关疾病的关键目标。TSHR信号传导失调可导致诸如格雷夫斯病等病症，其中自身抗体激活TSHR，导致甲状腺功能亢进。TSHR的结构完整性，尤其是第三细胞质环，对于TSHR的功能至关重要，因为该区域参与调节肌醇磷酸和环状AMP的形成，进一步强调了TSHR在内分泌信号通路中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TSHR 抗体 (4C1) 参考文献:

  1. 用小分子配体和抗体靶向促甲状腺激素受体。  |  Davies, TF. and Latif, R. 2015. Expert Opin Ther Targets. 19: 835-47. PMID: 25768836
  2. 甲状腺刺激素受体的遗传学--与自身免疫性甲状腺疾病的相关性》（Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease）。  |  Stefan, M. and Faustino, LC. 2017. Front Endocrinol (Lausanne). 8: 57. PMID: 28421036
  3. 妊娠期甲状腺刺激素受体抗体：临床意义。  |  Bucci, I., et al. 2017. Front Endocrinol (Lausanne). 8: 137. PMID: 28713331
  4. 甲状腺眼病中的促甲状腺激素受体抗体--方法和临床应用。  |  Diana, T. and Kahaly, GJ. 2018. Ophthalmic Plast Reconstr Surg. 34: S13-S19. PMID: 29771755
  5. 巴塞杜氏病中的促甲状腺激素受体（TSHR）融合蛋白。  |  Holthoff, HP., et al. 2020. J Endocrinol. 246: 135-147. PMID: 32573180
  6. 针对促甲状腺激素受体的抗体会导致巴塞杜氏病的母婴传播。  |  Yu, Y., et al. 2021. Exp Ther Med. 22: 1253. PMID: 34603521
  7. 小胶质细胞中功能性促甲状腺激素受体的表达  |  Liu, Y., et al. 2022. Ann Endocrinol (Paris). 83: 40-45. PMID: 34896340
  8. 促甲状腺激素受体信号传导可恢复肌肉萎缩症大鼠的骨骼肌干细胞再生。  |  Taglietti, V., et al. 2023. Sci Transl Med. 15: eadd5275. PMID: 36857434
  9. 新型抗嘌呤甲状腺刺激素受体单克隆抗体  |  Klee, AN., et al. 2023. Monoclon Antib Immunodiagn Immunother. 42: 109-114. PMID: 37343169
  10. 作为分化型甲状腺癌成像靶点的促甲状腺激素受体（TSHR）。  |  Gimblet, GR., et al. 2024. Surgery. 175: 199-206. PMID: 37919223

订购信息

产品名称产品编号规格价格数量收藏夹

TSHR 抗体 (4C1)

sc-32262
200 µg/ml
RMB2377.00

TSHR (4C1): m-IgG Fc BP-HRP 套装

sc-536726
200 µg Ab; 10 µg BP
RMB2662.00

TSHR (4C1): m-IgGκ BP-HRP 套装

sc-533887
200 µg Ab; 40 µg BP
RMB2662.00

TSHR (4C1): m-IgG2a BP-HRP 套装

sc-547859
200 µg Ab; 10 µg BP
RMB2662.00

TSHR 抗体 (4C1) FITC

sc-32262 FITC
200 µg/ml
RMB2482.00

TSHR 抗体 (4C1) PE

sc-32262 PE
200 µg/ml
RMB2580.00

How is this mAb expressed? Hybridoma? is the sequence known?

Asked by: R F Z
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801. ext.1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-10-18

Can TSHR (4C1): sc-32262 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Germaine
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, TSHR (4C1): sc-32262 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from Didn't work for IF staining of cryosectionsThe antibody did not work for cryo sections of primary human thyroid tissue.
Date published: 2019-02-08
Rated 5 out of 5 by from positive staining liver and lipid tissueI used the antibody 3 months ago. We used it evaluate the TSHR expression in thyroid, liver and lipid tissue. With the dilution of 1:500, the band is good in Western blot analysis.
Date published: 2016-12-08
Rated 5 out of 5 by from Excellent intracellular FCM data of fixedExcellent intracellular FCM data of fixed and permeabilized HeLa cells. -SCBT QC
Date published: 2015-06-01
Rated 5 out of 5 by from Nice indirect FCM data of GPINice indirect FCM data of GPI-anchored TSHR (Da Costa CR, Johnstone AP. -SCBT QC
Date published: 2014-08-06
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TSHR 抗体 (4C1) is rated 4.0 out of 5 by 4.
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