Date published: 2025-9-7

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Tropomyosin 抗体 (CH1): sc-58868

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说明书
  • Tropomyosin抗体(CH1)是小鼠单克隆IgG1 κ, 在9篇文献中引用,规格为200 µg/ml
  • 针对纯化的muscle Tropomyosin chicken 起源
  • 推荐用于 mouse, rat, human, avian 和 Xenopus 来源的striated muscle forms of Tropomyosin, including cardiac α Tropomyosin and skeletal muscle forms of Tropomyosin WB, IP, IF 和 IHC(P)检测; 可能与 chicken cardiac muscle产生交联反应; 不会与 smooth muscle or non-muscle isoforms of Tropomyosin产生交联反应
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Tropomyosin 抗体 (CH1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Tropomyosin 抗体 (CH1) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

原肌球蛋白是一组结构蛋白。原肌球蛋白几乎存在于所有真核细胞中,包括肌肉和非肌肉细胞,它们结合肌动蛋白丝并调节肌动蛋白-肌球蛋白相互作用,稳定肌动蛋白丝结构。原肌球蛋白α由TPM1基因编码,该基因位于人类染色体15q22.1,经历选择性剪接产生至少四种异构体,包括骨骼肌(异构体1)、平滑肌(异构体2)、成纤维细胞/TM3(异构体3)和异构体4。原肌球蛋白β由TPM2基因编码,该基因位于人类染色体9p13.3,经历选择性剪接产生三种异构体,包括骨骼肌(异构体1)、非肌肉/成纤维细胞TM36/上皮TMe1(异构体2)和非肌肉(异构体3)。原肌球蛋白I在特定区域与原肌球蛋白结合,原肌球蛋白-原肌球蛋白与肌动蛋白丝的结合可能会增加肌动蛋白丝的刚性。原肌球蛋白还与钙调素相互作用以调节平滑肌收缩。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Tropomyosin 抗体 (CH1) 参考文献:

  1. 原肌球蛋白在调节平滑肌收缩中的作用。  |  Marston, S. and El-Mezgueldi, M. 2008. Adv Exp Med Biol. 644: 110-23. PMID: 19209817
  2. 原肌球蛋白结构和功能的多态性。  |  Janco, M., et al. 2013. J Muscle Res Cell Motil. 34: 177-87. PMID: 23832280
  3. 哺乳动物原肌球蛋白同工酶的系统命名法。  |  Geeves, MA., et al. 2015. J Muscle Res Cell Motil. 36: 147-53. PMID: 25369766
  4. 原肌球蛋白对细胞质肌球蛋白的调控。  |  Manstein, DJ. and Mulvihill, DP. 2016. Traffic. 17: 872-7. PMID: 27060364
  5. 原肌球蛋白假磷酸化导致扩张型心肌病。  |  Rajan, S., et al. 2019. J Biol Chem. 294: 2913-2923. PMID: 30567734
  6. 神经营养性原肌球蛋白或酪氨酸受体激酶(NTRK)基因。  |  Chetty, R. 2019. J Clin Pathol. 72: 187-190. PMID: 30636697
  7. 以原肌球蛋白受体激酶为靶点进行癌症治疗。  |  Miao, Q., et al. 2019. Eur J Med Chem. 175: 129-148. PMID: 31077998
  8. 胃肠道间质瘤中的原肌球蛋白相关激酶融合。  |  Lee, JH., et al. 2022. Cancers (Basel). 14: PMID: 35681640
  9. 利用免疫-PCR技术超灵敏定量甲壳动物原肌球蛋白  |  Radomirović, M., et al. 2023. Int J Mol Sci. 24: PMID: 37895089
  10. 遗传性心肌病中的原肌球蛋白-肌钙蛋白复合物。  |  Juárez, CK., et al. 2024. Heart Rhythm. 21: 1173-1175. PMID: 38382684

订购信息

产品名称产品编号规格价格数量收藏夹

Tropomyosin 抗体 (CH1)

sc-58868
200 µg/ml
$316.00

Tropomyosin (CH1): m-IgG Fc BP-HRP 套装

sc-539104
200 µg Ab; 10 µg BP
$354.00

Tropomyosin (CH1): m-IgG1 BP-HRP 套装

sc-541262
200 µg Ab; 20 µg BP
$354.00

推荐用于 mouse, rat, human, avian 和 a 中的a 代表的物种是什么?

Asked by: 杨杨6666
感谢您的提问。“a”代表的就是“avian”,感谢您的提醒,我们会尽快修改官网信息的。更多问题,欢迎通过:电话(+86) 021-60936350、邮箱[email protected]、或选择网页上Live Chat中的“中文支持”,联系我们的技术支持部门。 Thanks for this question, the "a" means "avian", we will revise this information ASAP. For more questions, please contact our Asian Technical Service team at (+86) 021-60936350 or [email protected] or by live chat on our website.
Answered by: Technical Support 15
Date published: 2018-02-27

Are there any issues with using sc-58868: Tropomyosin (CH1) mouse monoclonal primary antibody on mouse samples?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-58868 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Positive signal in WB in HeLa and MIA PaCaPositive signal in WB in HeLa and MIA PaCa-2 whole cell lysates. -SCBT QC
Date published: 2015-07-02
Rated 5 out of 5 by from Good specificity in WB in Sol8 whole cell lysateGood specificity in WB in Sol8 whole cell lysate. -SCBT QC
Date published: 2015-05-05
Rated 5 out of 5 by from Strong band in WB in L8 whole cell lysateStrong band in WB in L8 whole cell lysate, rat skeletal muscle and human heart tissue extract. -SCBT QC
Date published: 2015-03-16
Rated 5 out of 5 by from WB publishable data with mouse spleenWB publishable data with mouse spleen - SCBT Publication Review
Date published: 2013-05-31
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Tropomyosin 抗体 (CH1) is rated 5.0 out of 5 by 4.
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