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TLR3 抗体 (TLR3.7): sc-32232

3.8(13)
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说明书
  • TLR3 抗体 TLR3.7 是小鼠单克隆 IgG1 κ，TLR3抗体, 在46篇文献中引用，规格为200 µg/ml
  • 针对全长TLR3，human起源
  • TLR3 抗体 (TLR3.7) 推荐用于WB, IF, FCM 和 ELISA，检测human 来源的 TLR3
  • 抗TLR3抗体（TLR3.7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取TLR3 (TLR3.7): sc-32232的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是TLR3 Antibody (TLR3.7) for WB applications. 的首选辅助检测试剂，这些试剂现与TLR3 Antibody (TLR3.7) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外TLR抗体，包括TLR1, TLR10, TLR2, TLR3, TLR4, TLR5, TLR7, TLR8和TLR9

TLR3抗体（TLR3.7）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫荧光（IF）、流式细胞术（FCM）和酶联免疫吸附测定（ELISA）检测人源TLR3蛋白。TLR3抗体（TLR3.7）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。TLR3通过识别双链RNA在免疫反应中发挥关键作用，双链RNA是与病毒感染相关的分子模式，可触发核因子κB（NFκB）的激活和I型干扰素的产生。这一功能对于启动有效的抗病毒反应至关重要，因为TLR3有助于检测和应对病毒病原体。TLR3主要在胎盘和胰腺中表达，且TLR3的表达仅限于特定树突状细胞亚群，这凸显了其在免疫监视中的特殊作用。TLR家族（包括TLR3）的特征是具有高度保守的Toll同源结构域，该结构域对于信号转导至关重要，而TLR家族成员对于调节炎症反应必不可少。了解TLR3的功能和信号通路对于制定抗病毒感染的治疗策略和提高疫苗功效非常重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TLR3 抗体 (TLR3.7) 参考文献:

  1. 人类白细胞中收费样受体（TLR）的差异表达和调节：树突状细胞中 TLR3 的选择性表达。  |  Muzio, M., et al. 2000. J Immunol. 164: 5998-6004. PMID: 10820283
  2. IFN-α 通过上调 TLR3 的表达，增强 TLR3 介导的人内皮细胞和上皮细胞中抗病毒细胞因子的表达。  |  Tissari, J., et al. 2005. J Immunol. 174: 4289-94. PMID: 15778392
  3. 抗病毒免疫中的 TLR3：关键角色还是旁观者？  |  Schröder, M. and Bowie, AG. 2005. Trends Immunol. 26: 462-8. PMID: 16027039
  4. TLR3 激活可抑制人类肥大细胞附着到纤维粘连蛋白和玻璃粘连蛋白上。  |  Kulka, M. and Metcalfe, DD. 2006. Mol Immunol. 43: 1579-86. PMID: 16280166
  5. TLR3 配体诱导活化的脾脏自然杀伤细胞向肝脏聚集。  |  Wang, J., et al. 2005. Cell Mol Immunol. 2: 449-53. PMID: 16426495
  6. 小胶质细胞通过 TLR3 识别双链 RNA。  |  Town, T., et al. 2006. J Immunol. 176: 3804-12. PMID: 16517751
  7. TLR3 可直接引发人类癌细胞凋亡。  |  Salaun, B., et al. 2006. J Immunol. 176: 4894-901. PMID: 16585585
  8. TLR3激动剂作为免疫治疗剂。  |  Nicodemus, CF. and Berek, JS. 2010. Immunotherapy. 2: 137-40. PMID: 20635920
  9. 肿瘤激活内皮细胞中的 TLR3-SLIT2 轴推动转移。  |  Tavora, B., et al. 2020. Nature. 586: 299-304. PMID: 32999457
  10. Toll样受体3（TLR3）调节机制及其在抗病毒先天免疫反应中的作用。  |  Chen, Y., et al. 2021. J Zhejiang Univ Sci B. 22: 609-632. PMID: 34414698
  11. TLR3启动条件对MSC免疫抑制特性的影响。  |  Tolstova, T., et al. 2023. Stem Cell Res Ther. 14: 344. PMID: 38031182
  12. TLR3激活通过促进肿瘤铁死亡增强肝癌放疗的远端效应。  |  Qiu, L., et al. 2024. EMBO Mol Med. 16: 1193-1219. PMID: 38671318

订购信息

产品名称产品编号规格价格数量收藏夹

TLR3 抗体 (TLR3.7)

sc-32232
200 µg/ml
RMB2377.00

TLR3 (TLR3.7): m-IgG Fc BP-HRP 套装

sc-526668
200 µg Ab; 10 µg BP
RMB2662.00

TLR3 (TLR3.7): m-IgG1 BP-HRP 套装

sc-532041
200 µg Ab; 20 µg BP
RMB2662.00

TLR3 抗体 (TLR3.7) AC

sc-32232 AC
500 µg/ml, 25% agarose
RMB3129.00

TLR3 抗体 (TLR3.7) HRP

sc-32232 HRP
200 µg/ml
RMB2377.00

TLR3 抗体 (TLR3.7) FITC

sc-32232 FITC
200 µg/ml
RMB2482.00

TLR3 抗体 (TLR3.7) PE

sc-32232 PE
200 µg/ml
RMB2580.00

TLR3 抗体 (TLR3.7) Alexa Fluor® 488

sc-32232 AF488
200 µg/ml
RMB2685.00

TLR3 抗体 (TLR3.7) Alexa Fluor® 546

sc-32232 AF546
200 µg/ml
RMB2685.00

TLR3 抗体 (TLR3.7) Alexa Fluor® 594

sc-32232 AF594
200 µg/ml
RMB2685.00

TLR3 抗体 (TLR3.7) Alexa Fluor® 647

sc-32232 AF647
200 µg/ml
RMB2685.00

TLR3 抗体 (TLR3.7) Alexa Fluor® 680

sc-32232 AF680
200 µg/ml
RMB2685.00

TLR3 抗体 (TLR3.7) Alexa Fluor® 790

sc-32232 AF790
200 µg/ml
RMB2685.00

Does ot cross react with mouse TLR2 ?

Asked by: Akriti
Thank you for your question. This antibody has not yet been tested in mouse and so that is not a recommended species at this time. We are still gathering data to show on our website. Check back for updates!
Answered by: Tech Service
Date published: 2019-12-11

Can TLR3 (TLR3.7): sc-32232 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jerojero
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, TLR3 (TLR3.7): sc-32232 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Works wellThis antibody can be used in ovine lymph node for related research.
Date published: 2021-04-16
Rated 1 out of 5 by from FACS on HFFThis antibody does not work on HFF cells in flow cytometry
Date published: 2018-11-01
Rated 1 out of 5 by from Funktioniert leider nicht bei mir im WB oder IFAK wurde in einer 1:200-Verdünnung im WB an stabil mit TLR3 transduzierten Hek-Zellen getestet. Leider konnte ich keine Bande in der richtigen Größe detektieren.
Date published: 2018-05-30
Rated 5 out of 5 by from Specific band obtainedTested on Human liver tissue (30ug) .There was a strong single band at the expected MW, great quality .Recommend used it in our labmates.
Date published: 2018-05-26
Rated 2 out of 5 by from Didn't work for meUsed at 1:250 dilution in PBST 5% milk to detect in unstimulated A549 and HaCaT cells - didn't show anything but didn't have a positive control so may just be no TLR3 expressed at basal level in these cells
Date published: 2017-10-30
Rated 3 out of 5 by from My review for TLR3 antibodyI applied for the sample sack a mouth ago. I used it to detect the TLR3 of human origin by Western Blotting (dilution 1:300, 1:200, 1:100). But I didn't detect the TLR3.
Date published: 2017-08-28
Rated 4 out of 5 by from Great IHC staining with paraffin-embedded tissueGreat signal staining in IHC with paraffin-embedded gastric tissue
Date published: 2017-08-11
Rated 5 out of 5 by from It is really greatThe results of Western Blot analysis were very good, the band was clear
Date published: 2017-05-10
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TLR3 抗体 (TLR3.7) is rated 3.8 out of 5 by 13.
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