Date published: 2025-9-6

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TLR2 抗体 (TL2.3): sc-21760

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说明书
  • TLR2抗体(TL2.3)是小鼠单克隆IgG2a κ, 在22篇文献中引用,规格为200 µg/ml
  • 针对来源于human的CHO-TLR2细胞
  • 推荐用于 human 来源的TLR2 WB, IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 (sc-21760 PE) 以及 荧光素 (sc-21760 FITC), 200 µg/ml, 用于IF, IHC(P) 和 FCM
  • 关于如何获取TLR2 (TL2.3): sc-21760免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是TLR2 Antibody (TL2.3) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与TLR2 Antibody (TL2.3) 打包提供(请参阅下面的订购信息)。

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TLR2抗体(TLR2.3)是一种IgG2aκ小鼠单克隆TLR2抗体,可通过IP、IF和FCM检测人源TLR2。TLR2抗体(TLR2.3)既可作为偶联抗TLR2抗体,也可作为非偶联抗TLR2抗体。基于序列相似性,最初鉴定出六种果蝇Toll受体的人类同源物,并命名为Toll样受体(TLR)。Toll受体参与介导果蝇胚胎发育中的背腹极化,并参与宿主免疫。TLR家族蛋白的特征在于高度保守的Toll同源(TH)结构域,该结构域对于Toll诱导的信号转导至关重要。TLR1以及其他TLR家族成员是I型跨膜受体,其特征在于包含由几个富含亮氨酸的区域以及单个细胞质Toll/IL-1R样结构域组成的细胞外结构域。TLR2和TLR4响应脂多糖(LPS)刺激而被激活,这导致NFkB的激活和易位,并表明这些受体参与介导炎症反应。TLR受体的表达在外周血白细胞、巨噬细胞和单核细胞中最高。 TLR6与TLR1高度同源,序列同一性大于65%,并且与其他TLR家族成员一样,它在激活后诱导NFκB信号传导。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TLR2 抗体 (TL2.3) 参考文献:

  1. TLR2在葡萄球菌疾病中的作用。  |  Fournier, B. 2012. Front Cell Infect Microbiol. 2: 167. PMID: 23316483
  2. 自身免疫性疾病中的TLR2和TLR4:综述。  |  Liu, Y., et al. 2014. Clin Rev Allergy Immunol. 47: 136-47. PMID: 24352680
  3. 靶向 TLR2 开发疫苗。  |  Basto, AP. and Leitão, A. 2014. J Immunol Res. 2014: 619410. PMID: 25057505
  4. TLR2:多发性硬化症中的先天免疫检查点。  |  Hossain, MJ., et al. 2015. Oncotarget. 6: 35131-2. PMID: 26459385
  5. TLR2作为细菌感染的治疗靶点。  |  Simpson, ME. and Petri, WA. 2020. Trends Mol Med. 26: 715-717. PMID: 32563557
  6. 角质细胞TLR2和TLR7通过小鼠中的瘙痒细胞因子和趋化因子导致慢性瘙痒。  |  Wang, ZH., et al. 2023. J Cell Physiol. 238: 257-273. PMID: 36436135
  7. 细菌TLR2/6配体阻断纤毛形成,解除Hedgehog信号的抑制,并扩大新皮层。  |  Mann, B., et al. 2023. mBio. 14: e0051023. PMID: 37052506
  8. RANK+TLR2+骨髓亚群在类风湿性关节炎中使自身免疫转化为关节破坏。  |  Zhang, W., et al. 2023. Elife. 12: PMID: 37204303
  9. TLR2介导实验性阻塞性肾病新生小鼠的肾细胞凋亡。  |  Wyczanska, M., et al. 2023. PLoS One. 18: e0294142. PMID: 38015955
  10. TRPV3通过转录调控TLR2促进痤疮中的皮脂细胞炎症。  |  Wei, Z., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167195. PMID: 38648901

订购信息

产品名称产品编号规格价格数量收藏夹

TLR2 抗体 (TL2.3)

sc-21760
200 µg/ml
RMB2377.00

TLR2 (TL2.3): m-IgG Fc BP-HRP 套装

sc-525506
200 µg Ab; 10 µg BP
RMB2662.00

TLR2 (TL2.3): m-IgG2a BP-HRP 套装

sc-546294
200 µg Ab; 10 µg BP
RMB2662.00

TLR2 抗体 (TLR2.3) FITC

sc-21760 FITC
200 µg/ml
RMB2482.00

TLR2 抗体 (TLR2.3) PE

sc-21760 PE
200 µg/ml
RMB2580.00

Can TLR2 (TLR2.3): sc-21760 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Germaine
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, TLR2 (TLR2.3): sc-21760 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 3 out of 5 by from WB worksI try this antibody on primary neurons to do Western Blot, It works.
Date published: 2017-09-11
Rated 1 out of 5 by from IHC Assay Review for mABApplication: Immunohistochemistry. Protocol: Standard protocol for saliva smear staining. Dilutions tested: 1:10, 1:30, 1:90, 1:270. Results: No staining observed.
Date published: 2017-08-31
Rated 4 out of 5 by from Publishable Western blot results using humanPublishable Western blot results using human breast milk. -SCBT Publication Review
Date published: 2015-04-14
Rated 4 out of 5 by from Publishable IHC/IF data in human colon samplesPublishable IHC/IF data in human colon samples -SCBT Publication Review
Date published: 2015-04-08
Rated 5 out of 5 by from Good antibody for westernGood antibody for western, clean background and specific band in Caco-2 whole cell lysate. -SCBT QC
Date published: 2015-03-02
Rated 4 out of 5 by from Worked great for Flow Cytometry on humanWorked great for Flow Cytometry on human peripheral blood leukocytes. -SCBT QC
Date published: 2014-05-12
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TLR2 抗体 (TL2.3) is rated 3.5 out of 5 by 6.
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