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TIMP-2 Antibody (H-4) - Western Blotting - Image 134156
TIMP-2 抗体 (H-4): sc-271932. 人重组 TIMP-2 的 Western 印迹分析.
TIMP-2 Antibody (H-4) - Western Blotting - Image 134156
TIMP-2 抗体 (H-4): sc-271932. 人重组 TIMP-2 的 Western 印迹分析.
TIMP-2 Antibody (H-4) - Immunohistochemistry - Image 161051
TIMP-2 抗体 (H-4): sc-271932. 福尔马林固定, 石蜡包埋的人肾上腺组织的免疫过氧化物酶染色, 显示腺细胞的胞浆染色.
TIMP-2 抗体 (H-4): sc-271932. 人重组 TIMP-2 的 Western 印迹分析.

TIMP-2 抗体 (H-4): sc-271932

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寫評論提問
说明书
  • TIMP-2抗体(H-4)是小鼠单克隆IgG2a κ, 在1篇文献中引用，规格为200 µg/ml
  • 免疫human物种的TIMP-2的氨基酸81-220
  • 推荐用于 mouse, rat 和 human 来源的TIMP-2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 TIMP-2 (3A4): sc-21735，可查看有标记的 TIMP-2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是TIMP-2 Antibody (H-4) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与TIMP-2 Antibody (H-4) 打包提供（请参阅下面的订购信息）。
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関連項目

额外TIMP抗体，包括TIMP-1, TIMP-2和TIMP-3

TIMP-1、TIMP-2、TIMP-3和TIMP-4（组织金属蛋白酶抑制剂1、2、3和4）与胶原酶、明胶酶和基质溶解素等金属蛋白酶复合，导致金属蛋白酶不可逆失活。已发现TIMP-1与EPA（红细胞增强活性）相同。甲状旁腺激素已被证明是成骨细胞中TIMP-2的调节因子。TIMP-3可能参与调节滋养层对子宫的侵袭，以及上皮细胞折叠过程中细胞外基质的重塑，以及上皮管的形成、分支和扩张。TIMP-4在心脏中表达最高，在肝脏、脑、肺、胸腺和脾脏中表达水平较低。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TIMP-2 抗体 (H-4) 参考文献:

  1. TIMP-2调节内皮细胞中VEGFR-2的磷酸化并增强磷酸二酯酶活性。  |  Lee, SJ., et al. 2010. Lab Invest. 90: 374-82. PMID: 20084057
  2. 内吞受体megalin/LRP-2对前MMP-2:TIMP-2复合物的细胞摄取。  |  Johanns, M., et al. 2017. Sci Rep. 7: 4328. PMID: 28659595
  3. 尿液[TIMP-2]·[IGFBP7]对成人急性肾损伤的诊断准确性：符合PRISMA标准的荟萃分析。  |  Liu, C., et al. 2017. Medicine (Baltimore). 96: e7484. PMID: 28682920
  4. MMP-2和TIMP-2的表达升高与肺癌风险相关。  |  Cao, C., et al. 2017. Oncotarget. 8: 80560-80567. PMID: 29113325
  5. 心力衰竭和慢性肾脏病患者中的MMP-2和TIMP-2。  |  Kobusiak-Prokopowicz, M., et al. 2018. Open Med (Wars). 13: 237-246. PMID: 29915813
  6. TIMP-2通过调节MMP-9抑制转移并预测结直肠癌的预后。  |  Wang, W., et al. 2019. Cell Adh Migr. 13: 273-284. PMID: 31293204
  7. TIMP-2 Rs8179090基因型与台湾肺癌风险的关系。  |  Liao, WC., et al. 2021. Anticancer Res. 41: 5425-5430. PMID: 34732411
  8. TIMP-2多态性对早产儿视网膜病变风险、严重程度、复发和治疗反应的影响。  |  Wu, PL., et al. 2022. Int J Mol Sci. 23: PMID: 36430677
  9. TIMP-2作为5-Fu耐药性结直肠癌的预测生物标志物。  |  Li, Y., et al. 2023. J Cancer Res Clin Oncol. 149: 7235-7246. PMID: 36905423
  10. 健康肾捐献者单侧肾切除术后，尿β-2微球蛋白增加，而TIMP-2和IGFBP7下降。  |  de Rooij, ENM., et al. 2024. Sci Rep. 14: 12901. PMID: 38839764

订购信息

产品名称产品编号规格价格数量收藏夹

TIMP-2 抗体 (H-4)

sc-271932
200 µg/ml
CNY2422.00

TIMP-2 (H-4): m-IgGκ BP-HRP 套装

sc-535066
200 µg Ab; 40 µg BP
CNY2715.00

TIMP-2 (H-4): m-IgG2a BP-HRP 套装

sc-546209
200 µg Ab; 10 µg BP
CNY2715.00

SCBT QC - does this antibody give a nice clean single band on WB? The blot showed in your picture is cut off above 34K do you detect bands higher than 34K?  I would like to use the antibody for IHC.... looking for a nice, really clean Ab

Asked by: Swati Naphade
Thank you for your question. The Western blot data that you are referring to is not representative of this antibody’s detection of endogenous TIMP-2 as it is against a recombinant protein. We do have very good IHC(P) data with this antibody and recommend it for this application. Alternatively, perhaps you would like to consider a more well established antibody with numerous citations for IHC, as well as Western blot and IHC/IF data, TIMP-2 Antibody (3A4): sc-21735 .
Answered by: Technical Support
Date published: 2018-12-11

Can TIMP-2 (H-4): sc-271932 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Cweed
Thank you for your question. Yes, TIMP-2 (H-4): sc-271932 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by JL from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human adrenal gland tissue. -SCBT QC
Date published: 2015-02-08
Rated 5 out of 5 by SS from Satisfactory Western Blot data of human recombinantSatisfactory Western Blot data of human recombinant TIMP-2. -SCBT QC
Date published: 2013-06-11
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TIMP-2 抗体 (H-4) is rated 5.0 out of 5 by 2.
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