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TIMP-2 抗体 (B-12): sc-365671

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说明书
  • TIMP-2抗体(B-12)是小鼠单克隆IgG1 κ, 在7篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的TIMP-2的C-terminus附近的氨基酸190-220之间
  • 推荐用于 mouse, rat 和 human 来源的TIMP-2 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 canine, bovine and porcine
  • 看 TIMP-2 (3A4): sc-21735,可查看有标记的 TIMP-2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是TIMP-2 Antibody (B-12) for WB applications. 的首选辅助检测试剂,这些试剂现与TIMP-2 Antibody (B-12) 打包提供(请参阅下面的订购信息)。
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関連項目

TIMP-1、TIMP-2、TIMP-3和TIMP-4(组织金属蛋白酶抑制剂1、2、3和4)与胶原酶、明胶酶和基质溶解素等金属蛋白酶复合,导致金属蛋白酶不可逆失活。已发现TIMP-1与EPA(红细胞增强活性)相同。甲状旁腺激素已被证明是成骨细胞中TIMP-2的调节因子。TIMP-3可能参与调节滋养层对子宫的侵袭,以及上皮细胞折叠过程中细胞外基质的重塑,以及上皮管的形成、分支和扩张。TIMP-4在心脏中表达最高,在肝脏、脑、肺、胸腺和脾脏中表达水平较低。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TIMP-2 抗体 (B-12) 参考文献:

  1. 肝纤维化大鼠中TIMP-1和TIMP-2的表达。  |  Nie, QH., et al. 2004. World J Gastroenterol. 10: 86-90. PMID: 14695775
  2. TIMP-2 破坏了 FGF-2 诱导的下游信号通路。  |  Seo, DW., et al. 2008. Microvasc Res. 76: 145-51. PMID: 18721821
  3. MMP-9和TIMP-2之间的相互作用调节了牙釉细胞瘤的行为和牙齿形态发生。  |  Nunia, K., et al. 2016. Appl Immunohistochem Mol Morphol. 24: 364-72. PMID: 26067137
  4. MMP-2和TIMP-2基因多态性与胃癌风险和预后的相关性。  |  Zhang, DY., et al. 2015. Int J Clin Exp Med. 8: 20391-401. PMID: 26884955
  5. 巩膜TIMP-2表达降低与近视发展有关:补充TIMP-2可稳定近视的巩膜生物标记物并限制近视发展。  |  Liu, HH., et al. 2017. Invest Ophthalmol Vis Sci. 58: 1971-1981. PMID: 28384717
  6. 分泌的c-Src酪氨酸激酶对TIMP-2进行细胞外磷酸化,从而控制MMP-2的活性。  |  Sánchez-Pozo, J., et al. 2018. iScience. 1: 87-96. PMID: 30227959
  7. 胰腺癌(PC)中的基质金属蛋白酶2(MMP-2)及其组织抑制剂2(TIMP-2)。  |  Łukaszewicz-Zając, M., et al. 2019. Oncotarget. 10: 395-403. PMID: 30719232
  8. 腺瘤-结直肠癌序列中MMP-2、MMP-7、MMP-9及其抑制剂TIMP-1和TIMP-2的行为。  |  Barabás, L., et al. 2021. Dig Dis. 39: 217-224. PMID: 32961536
  9. 脓毒症急性肾损伤生物标志物TIMP-2的效率评估。  |  Li, S., et al. 2023. Bull Exp Biol Med. 174: 790-796. PMID: 37160599
  10. 垂体肿瘤中MMP-2、MMP-9和TIMP-2的表达及其与海绵窦侵袭的关系。  |  Thé B Freire, AC., et al. 2025. Endocr Oncol. 5: e240037. PMID: 39810846

订购信息

产品名称产品编号规格价格数量收藏夹

TIMP-2 抗体 (B-12)

sc-365671
200 µg/ml
CNY2422.00

TIMP-2 (B-12): m-IgG Fc BP-HRP 套装

sc-540358
200 µg Ab; 10 µg BP
CNY2715.00

TIMP-2 (B-12): m-IgG1 BP-HRP 套装

sc-542065
200 µg Ab; 20 µg BP
CNY2715.00

TIMP-2 (B-12) 中和勝肽

sc-365671 P
100 µg/0.5 ml
CNY519.00

What application is the blocking peptide sc-365671 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by SF from Produced excellent immunofluorescence cytoplasmicProduced excellent immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-05-09
Rated 5 out of 5 by MS from WB Published with this antibody rat lungWB Published with this antibody rat lung cell samples for immunoblot analysis -SCBT Publication Review
Date published: 2015-01-29
Rated 5 out of 5 by JM from Good WB signal achieved against full lengthGood WB signal achieved against full length human recombinant TIMP-2 under non-reducing conditions. -SCBT QC
Date published: 2015-01-09
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TIMP-2 抗体 (B-12) is rated 5.0 out of 5 by 3.
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