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TIGAR 抗体 (F-5): sc-377065

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说明书
  • TIGAR抗体(F-5)是小鼠单克隆IgG2a κ, 在3篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的TIGAR的内部区域内的氨基酸81-121之间
  • 推荐用于 mouse, rat 和 human 来源的TIGAR WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP是TIGAR Antibody (F-5) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与TIGAR Antibody (F-5) 搭配使用(请参阅下面的订购信息)。

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関連項目

TIGAR(TP53(肿瘤蛋白53)诱导的糖酵解和凋亡调节因子),也称为C12orf5,是由p53肿瘤抑制通路诱导的270个氨基酸的蛋白质,其功能是保护细胞免受氧化应激。TIGAR与糖酵解途径中的果糖-2,6-二磷酸降解酶(果糖二磷酸酶或FBPase)的双磷酸结构域具有序列相似性,因此可以降低细胞内果糖-2,6-二磷酸的含量。TIGAR特异性地阻断糖酵解,导致该途径进入戊糖磷酸分流,降低细胞内活性氧的浓度。这表明TIGAR在保护细胞免受活性氧的损伤中发挥作用,活性氧可损伤DNA并导致细胞凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TIGAR 抗体 (F-5) 参考文献:

  1. 抑制c-Met可下调TIGAR的表达并减少NADPH的产生,从而导致细胞死亡。  |  Lui, VW., et al. 2011. Oncogene. 30: 1127-34. PMID: 21057531
  2. Tp53诱导的糖酵解和凋亡调节因子(TIGAR)可通过上调呼吸作用和改善细胞氧化还原平衡来保护神经胶质瘤细胞免受饥饿诱导的细胞死亡。  |  Wanka, C., et al. 2012. J Biol Chem. 287: 33436-46. PMID: 22887998
  3. TIGAR敲除通过调节结肠直肠癌细胞的细胞自噬和凋亡,增强了七叶皂苷的抗癌作用。  |  Li, B., et al. 2019. Acta Pharmacol Sin. 40: 111-121. PMID: 29769743
  4. TIGAR过表达导致的代谢重塑是食管鳞状细胞癌的治疗靶点。  |  Chu, J., et al. 2020. Theranostics. 10: 3488-3502. PMID: 32206103
  5. TIGAR敲除对阿霉素耐药的非小细胞肺癌A549细胞系中凋亡和上皮-间充质标志物表达的影响。  |  Agca, CA., et al. 2020. Chem Biodivers. 17: e2000441. PMID: 32639659
  6. 可切除性胰腺导管腺癌患者中TIGAR的表达及其与临床病理、预后和18F-FDG PET/CT参数的相关性。  |  Song, Y., et al. 2021. Nucl Med Commun. 42: 528-534. PMID: 33481504
  7. TP53诱导的糖酵解和凋亡调节因子(TIGAR)的表达可由人类癌细胞中的抗氧化协调因子NRF2控制。  |  Simon-Molas, H., et al. 2022. Int J Mol Sci. 23: PMID: 35163828
  8. 抑制TRIM35介导的TIGAR泛素化可增强线粒体融合并减轻肾缺血再灌注损伤。  |  Du, Y., et al. 2022. Int J Biol Macromol. 209: 725-736. PMID: 35421414
  9. 人参皂苷Rg3通过下调TIGAR诱导胃癌前病变大鼠细胞凋亡并抑制其增殖。  |  Lv, S., et al. 2022. BMC Complement Med Ther. 22: 188. PMID: 35840932
  10. Gankyrin 和 TIGAR 相互合作,加速了肝细胞癌中葡萄糖代谢的 PPP 和 TCA 循环。  |  Yang, C., et al. 2022. Cancer Sci. 113: 4151-4164. PMID: 36114745

订购信息

产品名称产品编号规格价格数量收藏夹

TIGAR 抗体 (F-5)

sc-377065
200 µg/ml
RMB2377.00

TIGAR (F-5): m-IgG Fc BP-HRP 套装

sc-540689
200 µg Ab; 10 µg BP
RMB2662.00

TIGAR (F-5) 中和勝肽

sc-377065 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-377065 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from No commentNo comment
Date published: 2015-03-20
Rated 5 out of 5 by from Produced positive Western blot data of TIGARProduced positive Western blot data of TIGAR expression in U-2 OS, Saos-2 and Jurkat whole cell lysates and human breast tissue extract . -SCBT QC
Date published: 2013-01-25
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TIGAR 抗体 (F-5) is rated 4.5 out of 5 by 2.
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