Date published: 2025-9-7
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Thrombin R Antibody (ATAP2) - Immunohistochemistry - Image 361363
凝血酶 R 抗体 (ATAP2): sc-13503. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色显示肾小球细胞膜和细胞质染色以及肾小管细胞的细胞质染色.
凝血酶 R 抗体 (ATAP2): sc-13503. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色显示肾小球细胞膜和细胞质染色以及肾小管细胞的细胞质染色.

Thrombin R 抗体 (ATAP2): sc-13503

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说明书
  • Thrombin R 抗体 ATAP2 是小鼠单克隆 IgG1 κ，Thrombin R抗体, 在195篇文献中引用，规格为200 µg/ml
  • 表位定位到Thrombin R的42-55氨基酸，该氨基酸来自human
  • Thrombin R 抗体 (ATAP2) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 Thrombin R
  • 抗Thrombin R抗体（ATAP2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还可偶联Alexa Fluor® 405 用于IF, IHC(P) 和FCM
  • 关于如何获取Thrombin R (ATAP2): sc-13503的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Thrombin R 抗体 (ATAP2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Thrombin R 抗体 (ATAP2) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 PAR 抗体 包括 PAR-2, PAR-3和PAR-4

凝血酶R抗体（ATAP2）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学和流式细胞术（FCM）检测小鼠、大鼠和人类来源的凝血酶R蛋白。凝血酶R单克隆抗体（ATAP2）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。凝血酶R（Thrombin R）也称为蛋白酶激活受体-1（PAR-1），通过调节凝血酶的作用在止血和炎症调节中发挥关键作用。凝血酶是一种丝氨酸蛋白酶，在血小板聚集和血液凝固中起着关键作用。在凝血酶的激活下，凝血酶R蛋白发生裂解，释放出一种41个氨基酸的肽，这种肽是一种强效血小板激动剂，可导致细胞质钙浓度升高。这种激活对于血管损伤的生理反应至关重要，因为它可促进血小板活化和聚集，从而促进血凝块的形成。凝血酶R蛋白主要位于细胞表面，可与凝血酶相互作用，但也会在细胞表面和细胞内池之间循环，这对于维持细胞对凝血酶的反应至关重要。此外，人类凝血酶R受转录因子（如Sp1和Sp3）调节，这凸显了其在各种生理和病理环境中的表达和功能的复杂性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Thrombin R 抗体 (ATAP2) 参考文献:

  1. PAR-1和凝血酶：将微环境与黑色素瘤转移联系起来的纽带。  |  Zigler, M., et al. 2011. Cancer Res. 71: 6561-6. PMID: 22009534
  2. 蛋白酶激活受体-1（PAR-1）：一种有前景的癌症分子靶标。  |  Liu, X., et al. 2017. Oncotarget. 8: 107334-107345. PMID: 29291033
  3. 凝血酶信号通过PAR-1依赖性免疫逃逸促进胰腺腺癌。  |  Yang, Y., et al. 2019. Cancer Res. 79: 3417-3430. PMID: 31048498
  4. 凝血酶/PAR-1激活通过妊娠糖尿病中的NLRP1炎症小体诱导内皮损伤。  |  Liu, Y., et al. 2020. Biochem Pharmacol. 175: 113849. PMID: 32059841
  5. G蛋白偶联受体激酶5通过PAR-1调节血小板中的凝血酶信号。  |  Downes, K., et al. 2022. Blood Adv. 6: 2319-2330. PMID: 34581777
  6. USP7-STAT3-颗粒酶-Par-1轴通过促进产生IL-5的Th2细胞分化来调节过敏性炎症。  |  Kumagai, J., et al. 2023. Proc Natl Acad Sci U S A. 120: e2302903120. PMID: 38015852
  7. 人内皮细胞中 Sp 家族转录因子对人凝血酶受体基因的差异转录调控。  |  Wu, Y., et al. 1998. Biochem J. 330 (Pt 3): 1469-74. PMID: 9494121
  8. 凝血酶受体的裂解肽是一种强血小板激动剂。  |  Furman, MI., et al. 1998. Proc Natl Acad Sci U S A. 95: 3082-7. PMID: 9501219
  9. 凝血酶  |  Goldsack, NR., et al. 1998. Int J Biochem Cell Biol. 30: 641-6. PMID: 9695019
  10. 蛋白酶激活受体基因家族的基因和基因座结构及染色体定域。  |  Kahn, ML., et al. 1998. J Biol Chem. 273: 23290-6. PMID: 9722561
  11. 蛋白酶激活受体 1 的独立于激动剂和激动剂触发的转运信号各不相同。  |  Shapiro, MJ. and Coughlin, SR. 1998. J Biol Chem. 273: 29009-14. PMID: 9786906
  12. 分析通过凝血酶受体途径介导超极化的 Ca2+ 激活的 K+ 通道。  |  Sullivan, R., et al. 1998. Am J Physiol. 275: C1342-8. PMID: 9814983

订购信息

产品名称产品编号规格价格数量收藏夹

Thrombin R 抗体 (ATAP2)

sc-13503
200 µg/ml
RMB2377.00

Thrombin R (ATAP2): m-IgG Fc BP-HRP 套装

sc-528282
200 µg Ab; 10 µg BP
RMB2662.00

Thrombin R (ATAP2): m-IgGκ BP-HRP 套装

sc-520621
200 µg Ab, 40 µg BP
RMB2662.00

Thrombin R (ATAP2): m-IgG1 BP-HRP 套装

sc-542851
200 µg Ab; 20 µg BP
RMB2662.00

Thrombin R 抗体 (ATAP2) AC

sc-13503 AC
500 µg/ml, 25% agarose
RMB3129.00

Thrombin R 抗体 (ATAP2) HRP

sc-13503 HRP
200 µg/ml
RMB2377.00

Thrombin R 抗体 (ATAP2) FITC

sc-13503 FITC
200 µg/ml
RMB2482.00

Thrombin R 抗体 (ATAP2) PE

sc-13503 PE
200 µg/ml
RMB2580.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 488

sc-13503 AF488
200 µg/ml
RMB2685.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 546

sc-13503 AF546
200 µg/ml
RMB2685.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 594

sc-13503 AF594
200 µg/ml
RMB2685.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 647

sc-13503 AF647
200 µg/ml
RMB2685.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 680

sc-13503 AF680
200 µg/ml
RMB2685.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 790

sc-13503 AF790
200 µg/ml
RMB2685.00

Thrombin R 抗体 (ATAP2) Alexa Fluor® 405

sc-13503 AF405
200 µg/ml
RMB2685.00

Can we use Thrombin R Antibody (ATAP2) (sc-13503) for receptor blocking?

Asked by: hyry
Grazie mille per la domanda. Il prodotto è raccomandato e garantito per il rilevamento di Thrombin R di origine mouse, rat e human in WB, IP, IF, IHC(P) e FCM. La Santa Cruz Biotechnology garantisce i suoi prodotti per un anno dalla data d'acquisto nelle applicazioni citate, ogni altro utilizzo non può essere garantito in quanto non testato. Per favore contatti il nostro servizio tecnico per ulteriori informazioni.
Answered by: Technical Support Europe
Date published: 2020-04-15

What negative control should be used when using the conjugated version of Thrombin R Antibody (ATAP2): sc-13503 in flow cytometry?

Asked by: jenni
We recommend using the isotype specific normal mouse IgG conjugated to the same fluorophore. For example, if you are using sc-13503 PE, then you would want to use normal mouse IgG1 PE, sc-2866.
Answered by: Technical Support 8
Date published: 2017-01-06
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Rated 5 out of 5 by from Great for Western blotNice prominent band for vascular smooth muscle cells!
Date published: 2019-02-19
Rated 5 out of 5 by from Good antibody for immunohistochemistryWorks well with swine kidney tissues for IHC. Strongly recommend it.
Date published: 2017-06-19
Rated 5 out of 5 by from Good antibody for WBThis monoclonal antibody is superior to previously offered polyclonal antibody sc-5605 when considering Western Blotting technique. The bands correspond to product description and expected protein mass. Strongly recommended!
Date published: 2017-05-12
Rated 5 out of 5 by from OutstandingGreat antibody for several applications including wb, ihc and fa staining
Date published: 2017-01-03
Rated 5 out of 5 by from A great research tool!This antibody is an excellent choice for Thrombin R detection. It provides great specific data in WB and staining procedures. It works with mouse, rat, and human samples and has over 60 citations to support it.
Date published: 2016-12-30
Rated 5 out of 5 by from Good publishable data in Flow cytometry inGood publishable data in Flow cytometry in human Oral epithelial KB, HSC-2 and Ho-1-u-1. -SCBT Publication Review
Date published: 2015-04-30
Rated 5 out of 5 by from Strong band in WB in MIA PaCaStrong band in WB in MIA PaCa-2, HeLa, TF-1, HEL 92.1.7 and ECV304 whole cell lysates. -SCBT QC
Date published: 2015-04-02
Rated 5 out of 5 by from Produced superb immunoperoxidase cytoplasmicProduced superb immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human testis tissue. -SCBT QC
Date published: 2015-01-11
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Thrombin R 抗体 (ATAP2) is rated 5.0 out of 5 by 9.
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