Date published: 2025-9-6
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TGF beta 1 Antibody (3C11) - Western Blotting - Image 136774
TGFβ1 抗体 (3C11): sc-130348. 人重组 TGFβ1 的 Western 印迹分析.
TGF beta 1 Antibody (3C11) - Western Blotting - Image 136774
TGFβ1 抗体 (3C11): sc-130348. 人重组 TGFβ1 的 Western 印迹分析.
TGFβ1 抗体 (3C11): sc-130348. 人重组 TGFβ1 的 Western 印迹分析.

TGF beta 1 抗体 (3C11): sc-130348

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说明书
  • TGF beta 1 抗体 3C11 是小鼠单克隆 IgG1 κ，TGF beta 1抗体, 在298篇文献中引用，规格为200 µg/ml
  • TGF beta 1 抗体 (3C11) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 TGFβ1
  • 抗TGF beta 1抗体（3C11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取TGF beta 1 (3C11): sc-130348的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 TGF beta 1 抗体 (3C11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与TGF beta 1 抗体 (3C11) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 TGF 抗体 包括 TGF α, TGF β 1, TGF β 2, TGF β 3和TGF β

TGFβ1抗体（3C11）是一种IgG1 κ小鼠单克隆TGF-β1抗体（也称为TGFB1抗体或TGF-β1抗体），可通过WB、IP、IF和IHC(P)检测小鼠、大鼠和人类来源的TGF-β1蛋白。TGFβ1抗体（3C11）既可以是非偶联的抗TGF-β1抗体形式，也可以是多种偶联形式的抗TGF-β1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。转化生长因子β（TGFβs）最初是因其能够在存在TGFα的情况下促进大鼠NRK成纤维细胞的非锚定生长而被发现的。现在人们已经认识到，TGFβs介导了胚胎发育过程中发生的许多细胞-细胞相互作用。在哺乳动物中已经发现了三种TGFβs。TGFβ1、TGFβ2和TGFβ3都是作为前体蛋白合成的，这些前体蛋白非常相似，每个都被裂解产生一个112个氨基酸的多肽，该多肽仍然与分子的潜伏部分相关联。具有生物活性的TGFβ需要单体的二聚化（通常为同二聚体）和潜伏肽部分的释放。总体而言，TGFβ3蛋白的成熟区域与TGFβ1和TGFβ2的成熟区域具有约80%的同源性。然而，它们分子的NH2末端或前体区域仅具有27%的序列同源性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TGF beta 1 抗体 (3C11) 参考文献:

  1. TGF-β1，回到未来：重新审视其作为转化生长因子的作用。  |  Glick, AB. 2004. Cancer Biol Ther. 3: 276-83. PMID: 15034302
  2. 内胚层蛋白对颉颃物转化生长因子-β1和BMP-7的信号转导起着不同的调节作用。  |  Scherner, O., et al. 2007. J Biol Chem. 282: 13934-43. PMID: 17376778
  3. 转化生长因子-β。生长调节肽家族。  |  Miller, DA., et al. 1990. Ann N Y Acad Sci. 593: 208-17. PMID: 2375595
  4. 转化生长因子 beta3 的分子特征。  |  ten Dijke, P., et al. 1990. Ann N Y Acad Sci. 593: 26-42. PMID: 2375596
  5. TGF-β1 在海马突触可塑性和记忆中的关键作用  |  Caraci, F., et al. 2015. Sci Rep. 5: 11252. PMID: 26059637
  6. 重组 TGF-beta 1 合成为一种双组分潜伏复合物，与原生血小板潜伏 TGF-beta 1 复合物具有某些结构特征。  |  Wakefield, LM., et al. 1989. Growth Factors. 1: 203-18. PMID: 2629880
  7. 鉴定转化生长因子β型基因家族的另一个成员。  |  ten Dijke, P., et al. 1988. Proc Natl Acad Sci U S A. 85: 4715-9. PMID: 3164476
  8. 人类胶质母细胞瘤衍生 T 细胞抑制因子（转化生长因子-β 基因家族的新成员）的互补 DNA。  |  de Martin, R., et al. 1987. EMBO J. 6: 3673-7. PMID: 3322813
  9. TGFβ1通过下调TRPA1通道诱导人肺肌成纤维细胞抵抗细胞死亡。  |  Virk, HS., et al. 2021. Br J Pharmacol. 178: 2948-2962. PMID: 33786825
  10. 人类转化生长因子-β互补 DNA 序列及在正常细胞和转化细胞中的表达。  |  Derynck, R., et al. Nature. 316: 701-5. PMID: 3861940
  11. 某些人类肿瘤细胞产生的转化生长因子：与表皮生长因子受体相互作用的多肽。  |  Todaro, GJ., et al. 1980. Proc Natl Acad Sci U S A. 77: 5258-62. PMID: 6254071
  12. 来自病毒转化细胞条件培养基的肉瘤生长因子由α型和β型转化生长因子组成。  |  Anzano, MA., et al. 1983. Proc Natl Acad Sci U S A. 80: 6264-8. PMID: 6604914

订购信息

产品名称产品编号规格价格数量收藏夹

TGF beta 1 抗体 (3C11)

sc-130348
200 µg/ml
RMB2377.00

TGF beta 1 (3C11): m-IgG Fc BP-HRP 套装

sc-527081
200 µg Ab; 10 µg BP
RMB2662.00

TGF beta 1 (3C11): m-IgG1 BP-HRP 套装

sc-532454
200 µg Ab; 20 µg BP
RMB2662.00

TGF beta 1 抗体 (3C11) AC

sc-130348 AC
500 µg/ml, 25% agarose
RMB3129.00

TGF beta 1 抗体 (3C11) HRP

sc-130348 HRP
200 µg/ml
RMB2377.00

TGF beta 1 抗体 (3C11) FITC

sc-130348 FITC
200 µg/ml
RMB2482.00

TGF beta 1 抗体 (3C11) PE

sc-130348 PE
200 µg/ml
RMB2580.00

TGF beta 1 抗体 (3C11) Alexa Fluor® 488

sc-130348 AF488
200 µg/ml
RMB2685.00

TGF beta 1 抗体 (3C11) Alexa Fluor® 546

sc-130348 AF546
200 µg/ml
RMB2685.00

TGF beta 1 抗体 (3C11) Alexa Fluor® 594

sc-130348 AF594
200 µg/ml
RMB2685.00

TGF beta 1 抗体 (3C11) Alexa Fluor® 647

sc-130348 AF647
200 µg/ml
RMB2685.00

TGF beta 1 抗体 (3C11) Alexa Fluor® 680

sc-130348 AF680
200 µg/ml
RMB2685.00

TGF beta 1 抗体 (3C11) Alexa Fluor® 790

sc-130348 AF790
200 µg/ml
RMB2685.00

What's the immunogen of this antibody? more specifically, what's the correponding peptide fragment of TGFbeta1? Thank you!

Asked by: Kate
Thank you for your question. The antibody anti-TGFbeta1(clone 3C11), is raised against amino acids 1-111 of the TGFβ1 full length protein.
Answered by: BlakeJ
Date published: 2024-03-28

Do you know if there is any cross reactivity with horse tissues?

Asked by: Anonymous
Thank you for your question. TGF beta 1 Antibody (TB21): sc-52893 is recommended for detection of natural and recombinant TGFβ1, both dimeric and monomeric natural forms under reducing and non reducing conditions of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. It has not been evaluated in equine cell or tissue samples.
Answered by: Tech Support Europe
Date published: 2023-08-15

I am not getting bands in western blot for tgfbeta 1 antibody against mice brain tissue. Can you suggest something?

Asked by: Xyz1
Thank you for contacting Santa Cruz Biotechnology. Please contact technical service . (800)-457-3801 or [email protected]
Answered by: BlakeJ
Date published: 2023-07-25

Whether there is neutralization effect

Asked by: wlw111
Thank you for your question. TGF beta 1 Antibody (3C11) is recommended for detection of TGFβ1 of mouse, rat and human origin by WB, IF and IHC(P). We do not recommend that this antibody use in living animals or in vivo.
Answered by: Ling Chen
Date published: 2023-06-07

Hello, does this antibody (3C11) recognize active monomeric or dimeric TGFbeta, which is secreted from human cells into the medium (conditioned medium)?

Asked by: hoba
Thank you for your question. This antibody is capable of detecting both the dimeric and monomeric form of its target protein.
Answered by: Tech Support Europe
Date published: 2022-12-19

Hello, In order to purchase this item we need to get MSDS. please provide with MSDS. Thank you

Asked by: YanaM
Thank you for your question. We do not offer MSDS documentation for antibody products, as they are non-hazardous.
Answered by: Tech Support Europe
Date published: 2022-03-09

マウス組織でもIHCやWBでTGFβ1発現は確認できますか？

Asked by: khkto
Thank you for your question. Anti-TGF beta 1 Antibody (3C11) is recommended for detection of TGFβ1 of mouse, rat and human origin by WB, IF and IHC(P).
Answered by: Sen Li
Date published: 2021-09-30

Dear sir/ madam, I would be interested on testing this antibody as a part of my research plan. Could I purchase a free sample of this antibody to test it’s affinity on the specific samples I’m examining. I’m looking forward to hearing from you, thankyou

Asked by: Erasmia
Please contact Technical Service
Answered by: Tech Sales
Date published: 2021-04-29
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Rated 5 out of 5 by from Works well for WBWorks well on neonatal mouse lungs at concentration of 30ug. Ab dilution will be 1:200 for overnight @ 4oC.
Date published: 2024-12-10
Rated 2 out of 5 by from Basso segnaleLo abbiamo testato in western blot condizioni riducenti, in milk 5% ad una diluizione di 1:200 ed incubazione overnight. Abbiamo corso sia lisati cellulari (40 ug) di intestino di topo che vescicole extracellulari da tessuto intestinale di topo. Nei lisati abbiamo ottenuto un segnale dopo sviluppo con super-enhancer Femto (Life Technologies), mentre nei campioni di vescicole (16 ug) è stato molto difficile ottenere un segnale anche con super-enhancer. Il segnale ci è comquneu sembrato specifico. Potrebbe andare bene per campioni abbondanti.
Date published: 2024-02-08
Rated 5 out of 5 by from well function in WB and IFGood results when tested TGF beta 1 in western blot of whole cell extracts or IF from Human prostate cancer cell PC-3 and DU145 cell line.
Date published: 2023-12-22
Rated 5 out of 5 by from PerfectIt works very well. The bands were clear. Good for wb
Date published: 2022-04-07
Rated 5 out of 5 by from It worked very goodEasy to buy and very promising results. I believe I will need another vial!
Date published: 2021-09-30
Rated 5 out of 5 by from よく染まりますIHCを行いました。1：1000の希釈、4℃ overnightで反応させて、しっかり染まりました。
Date published: 2021-08-27
Rated 3 out of 5 by from The antibody works quite well in IFThe antibody works quite well in immunofluorescence (1:200) on mesenchymal stem cells fixed with 4% PFA
Date published: 2020-11-10
Rated 4 out of 5 by from Western blottingIt is very good quality for western blotting anaylsis.
Date published: 2020-08-22
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TGF beta 1 抗体 (3C11) is rated 4.3 out of 5 by 56.
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