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TFIIH p80 Antibody (184.7) - Western Blotting - Image 34536
TFIIH p80 抗体 (184. 7): sc-101174. HeLa 核提取物中 TFIIH 表达的 Western 印迹分析.
TFIIH p80 Antibody (184.7) - Western Blotting - Image 34536
TFIIH p80 抗体 (184. 7): sc-101174. HeLa 核提取物中 TFIIH 表达的 Western 印迹分析.
TFIIH p80 Antibody (184.7) - Western Blotting - Image 38756
TFIIH p80 抗体 (184. 7): sc-101174. 未转染 293T: sc-117752 (A), 转染人 TFIIH p80 的 293T: sc-111706 (B) 和 HeLa (C) 全细胞裂解液中 TFIIH p80 表达的 Western 印迹分析.
TFIIH p80 Antibody (184.7) - Western Blotting - Image 48671
TFIIH p80 抗体 (184. 7): sc-101174. 未转染 293T: sc-117752 (A), 转染小鼠 TFIIH p80 的 293T: sc-127645 (B) 和 HeLa (C) 全细胞裂解液中 TFIIH p80 表达的 Western 印迹分析.
TFIIH p80 抗体 (184. 7): sc-101174. HeLa 核提取物中 TFIIH 表达的 Western 印迹分析.

TFIIH p80 抗体 (184.7): sc-101174

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寫評論提問

说明书
  • TFIIH p80抗体(184.7)是小鼠单克隆IgG1 κ, 在8篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组TFIIH p80
  • 推荐用于 mouse, rat 和 human 来源的TFIIH p80 WB, IP 和 ELISA检测
  • 目前，我们还没有完成TFIIH p80 抗体 (184.7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 TFIIH 抗体 包括 TFIIH p44, TFIIH p52, TFIIH p62, TFIIH p80和TFIIH p89

真核生物中编码蛋白的基因的转录起始是一个复杂的过程，需要RNA聚合酶II以及基础转录因子家族。TFIID（TBP）因子与TATA框的结合被认为是形成含有几个附加因子的多蛋白复合物的第一步，这些附加因子包括TFIIA、TFIIB、TFIIE、TFIIF和TFIIH。TFIIH（或BTF2）是一个具有多种酶活性的多亚基转录/DNA修复因子。TFIIH的核心由5个亚基组成，分别命名为p89（XPB或ERCC3）、p62、p52、p44和p34。TFIIH复合物的附加亚基是p80（XPD或ERCC2）和由Cdk7、细胞周期蛋白H和MAT1组成的三元激酶复合物。p89和p80都具有ATP依赖性解旋酶活性。已证明p62、p52和p44亚基参与核苷酸切除修复。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TFIIH p80 抗体 (184.7) 参考文献:

  1. XPD/ERCC2多态性对不同种族胃癌风险的影响：系统综述和荟萃分析。  |  Xue, H., et al. 2012. PLoS One. 7: e43431. PMID: 23028453
  2. XPD多态性对非小细胞肺癌铂类化疗的预测价值：系统综述和荟萃分析。  |  Qiu, M., et al. 2013. PLoS One. 8: e72251. PMID: 23977265
  3. XPD通过miR-29a-3p-Mdm2/PDGF-B轴抑制HCC的细胞增殖和迁移。  |  Xiao, Z., et al. 2019. Cell Biosci. 9: 6. PMID: 30627419
  4. XPD/ERCC2 突变会干扰细胞对氧化应激的反应。  |  Lerner, LK., et al. 2019. Mutagenesis. 34: 341-354. PMID: 31348825
  5. 克隆 XPD 基因及其在恶性黑色素瘤细胞中的功能。  |  Wang, Y., et al. 2020. Oncol Lett. 20: 1803-1809. PMID: 32724423
  6. XPD 多态性与肝细胞癌和胃癌的风险：一项元分析  |  Zhou, Q., et al. 2021. Technol Cancer Res Treat. 20: 1533033821990046. PMID: 33517857
  7. XPD的磷酸化促使其发挥独立于DNA修复和转录功能的有丝分裂作用。  |  Compe, E., et al. 2022. Sci Adv. 8: eabp9457. PMID: 35977011
  8. NOP2介导的XPD的m5C甲基化与肝细胞癌的进展有关。  |  Sun, GF. and Ding, H. 2023. Neoplasma. 70: 340-349. PMID: 37498063
  9. 人类 XPD 螺旋酶对两种光子的不同结构和动力学描述验证差异。  |  Fu, I., et al. 2023. Nucleic Acids Res. 51: 12261-12274. PMID: 37933861
  10. 在交联 DNA 上停滞的 XPD 可深入了解损伤验证。  |  Kuper, J., et al. 2024. Nat Struct Mol Biol. 31: 1580-1588. PMID: 38806694

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产品名称产品编号规格价格数量收藏夹

TFIIH p80 抗体 (184.7)

sc-101174
100 µg/ml
RMB2504.00

I will use this antibody to detect a truncated version of ERCC2, therefore I would like to know the epitope that is recognized by this antibody. Could you please tell me where exactly the antibody binds? Thanks a lot.

Asked by: PostDoc
Thank you for your question. This antibody was made against a full length recombinant protein. The exact epitope has not been mapped.
Answered by: Tech Service
Date published: 2019-01-14

For Western Blot, is it recommended to use denatured or non-denatured conditions with TFIIH p80 (184.7): sc-101174 antibody?

Asked by: AbPolly
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 3 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-03-29
Rated 4 out of 5 by from Published IP data using yeast samplesPublished IP data using yeast samples. -SCBT Publication Review
Date published: 2015-03-22
Rated 4 out of 5 by from Successfully used to IP TFIIH p80 from HeLaSuccessfully used to IP TFIIH p80 from HeLa cells; verified pull down via WB with the same antibody. -SCBT Publication Review
Date published: 2015-01-09
Rated 5 out of 5 by from Clean band in western blot analysis of TFIIHClean band in western blot analysis of TFIIH expression in HeLa nuclear extract. -SCBT QC
Date published: 2013-03-11
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TFIIH p80 抗体 (184.7) is rated 4.0 out of 5 by 4.
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