Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

TFIIA-α/β 抗体 (708C4a): sc-81398

3.8(5)
寫評論提問

说明书
  • TFIIA- alpha / beta 抗体 708C4a 是小鼠单克隆 IgG1TFIIA-α/β抗体,规格为100 µg/ml
  • 针对与human TFIIA-α/β N-terminus附近区域相对应的重组蛋白
  • 推荐用于 TFIIA-α (35 kDa) of mouse, rat and human origin, and TFIIA-β (19 kDa) of human origin WB 和 IP检测
  • 关于如何获取TFIIA-α/β (708C4a): sc-81398免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成TFIIA-α/β 抗体 (708C4a)的首选二抗检测试剂的鉴定。这项工作正在进行中。

    快捷链接

    関連項目

    TFIIA-α/β抗体(708C4a)是一种小鼠单克隆IgG1抗体,可通过蛋白质印迹(WB)和免疫沉淀(IP)检测小鼠、大鼠和人类来源的TFIIA-α/β。TFIIA-α/β(708C4a)抗体可作为非结合TFIIA-α/β单克隆同种型抗体使用。TFIIA-α/β在真核生物中启动蛋白质编码基因的转录中起着至关重要的作用,这一过程对于基因表达和细胞功能至关重要。TFIIA-α/β由三个亚基组成:TFIIA-α、TFIIA-β和TFIIA-γ,它们共同作用,稳定TATA结合蛋白(TBP)与DNA在TATA盒处的相互作用。这种稳定性有助于预启动复合物(PIC)的形成,而预启动复合物是招募RNA聚合酶II和其他转录因子的必要条件。TFIIA-α/β通过直接与TBP和TATA盒结合,增强基因的转录输出,成为基因表达调控的关键参与者。TFIIA-α/β能够调节TBP对TATA结合元件的识别,这凸显了TFIIA-α/β在转录机制中的重要性,它影响着各种细胞过程和反应。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    TFIIA-α/β 抗体 (708C4a) 参考文献:

    1. TFIIAalpha/beta 样因子由一个生殖细胞特异基因编码,在小鼠精子发生过程中,该基因的表达与其他一般转录因子一起上调。  |  Han, SY., et al. 2001. Biol Reprod. 64: 507-17. PMID: 11159353
    2. TFIIA 在应对氧化应激方面发挥作用。  |  Kraemer, SM., et al. 2006. Eukaryot Cell. 5: 1081-90. PMID: 16835452
    3. 参与哺乳动物 RNA 聚合酶 II 特异转录的因子。因子 IIH 的鉴定和特征描述  |  Flores, O., et al. 1992. J Biol Chem. 267: 2786-93. PMID: 1733973
    4. TFIIA 可改变 TBP/TATA 复合物中 DNA 的构象,提高其动力学稳定性。  |  Hieb, AR., et al. 2007. J Mol Biol. 372: 619-32. PMID: 17681538
    5. 非放射性、超灵敏的位点特异性蛋白质-蛋白质光交联:TATA结合蛋白α-螺旋2与一般转录因子TFIIA和转录抑制因子NC2的相互作用。  |  Kim, Y., et al. 2008. Nucleic Acids Res. 36: 6143-54. PMID: 18824481
    6. 哺乳动物 RNA 聚合酶 II 参与特异性转录的因子:转录因子 IIA, IID 和 IIB 在转录功能复合体形成过程中的作用。  |  Maldonado, E., et al. 1990. Mol Cell Biol. 10: 6335-47. PMID: 2247058
    7. 一种 RNA 聚合酶 II 转录因子具有受启动子 TATA 区域强烈刺激的相关 DNA 依赖性 ATP 酶(dATP 酶)活性。  |  Conaway, RC. and Conaway, JW. 1989. Proc Natl Acad Sci U S A. 86: 7356-60. PMID: 2552440
    8. Taspase1处理改变了TFIIA辅助因子在TFIID调节中的性质。  |  Malecová, B., et al. 2015. Transcription. 6: 21-32. PMID: 25996597
    9. RNA 聚合酶 II 启动转录过程中的五个中间复合物。  |  Buratowski, S., et al. 1989. Cell. 56: 549-61. PMID: 2917366
    10. 哺乳动物 RNA 聚合酶 II 参与特异性转录的因子:TFIID 的纯化, 遗传特异性和 TATA 盒与启动子的相互作用。  |  Nakajima, N., et al. 1988. Mol Cell Biol. 8: 4028-40. PMID: 3185540
    11. 人类通用转录因子 TFIIA:编码小亚基的 cDNA 的特征以及基础和激活转录的要求。  |  DeJong, J., et al. 1995. Proc Natl Acad Sci U S A. 92: 3313-7. PMID: 7724559
    12. 人类 TFIIA 小(γ)亚基的分子克隆揭示了激活转录的关键功能。  |  Ozer, J., et al. 1994. Genes Dev. 8: 2324-35. PMID: 7958899

    订购信息

    产品名称产品编号规格价格数量收藏夹

    TFIIA-α/β 抗体 (708C4a)

    sc-81398
    100 µg/ml
    RMB2504.00

    I am using TFIIA-α/β (708C4a): sc-81398 antibody for immunoprecipitation, how much antibody should I use?

    Asked by: Germaine
    Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
    Answered by: Technical Support
    Date published: 2017-03-24
    • y_2025, m_9, d_7, h_4CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_81398, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 103ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Good for Western BlotAntibody detects a band at the expected molecular weight in human cell lines Jurkat and HepG2, Shown with Cruz Marker molecular weight standards, sc-2035. -SCBT QC
    Date published: 2023-09-14
    Rated 1 out of 5 by from Not working at allI used the recommended concentration at 1:200 for Hela S3 NE, no bands at right size.
    Date published: 2018-04-23
    Rated 5 out of 5 by from Well done in WBWe detected positive signal in WB using 293T whole cell extract
    Date published: 2016-11-21
    Rated 5 out of 5 by from Good specificity and signal strength in JurkatGood specificity and signal strength in Jurkat, Hep G2 and HeLa whole cell lysates. -SCBT QC
    Date published: 2015-05-18
    Rated 3 out of 5 by from Crisp single band observed by WB at expectedCrisp single band observed by WB at expected molecular weight for the human recombinant TFIIA- / protein. -SCBT QC
    Date published: 2013-11-02
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_5
    • loc_zh_CN, sid_81398, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 16ms
    • REVIEWS, PRODUCT
    TFIIA-α/β 抗体 (708C4a) is rated 3.8 out of 5 by 5.
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_5
    • loc_zh_CN, sid_81398, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 102ms
    • REVIEWS, PRODUCT