Date published: 2025-9-7

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Telethonin 抗体 (G-11): sc-25327

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说明书
  • Telethonin 抗体 G-11 是小鼠单克隆 IgG1 κ,Telethonin抗体, 在16篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Telethonin的氨基酸58-167
  • Telethonin 抗体 (G-11) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 telethonin
  • 抗Telethonin抗体(G-11)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Telethonin (G-11): sc-25327免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 Telethonin 抗体 (G-11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Telethonin 抗体 (G-11) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Telethonin 抗体(G-11)是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的 Telethonin 蛋白。抗Telethonin抗体(G-11)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。Telethonin在肌肉功能中起着至关重要的作用,特别是在肌节(横纹肌的基本收缩单位)的组装和维护中。通过与titin结合,Telethonin有助于在肌肉收缩过程中稳定肌原纤维的结构,对于肌原纤维生成过程中细胞骨架的正常组织至关重要。这种相互作用对于肌肉的完整性和功能至关重要,因为Telethonin或titin的任何破坏都可能导致肌肉疾病。Telethonin主要存在于心脏和骨骼肌的肌节中,它有助于肌肉组织的机械特性,并有助于收缩过程中的力量传递。了解Telethonin在肌肉生理学中的作用对于制定肌肉相关疾病的治疗策略非常重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Telethonin 抗体 (G-11) 参考文献:

  1. 肌肉组装:泰坦尼克号般的成就?  |  Gregorio, CC., et al. 1999. Curr Opin Cell Biol. 11: 18-25. PMID: 10047523
  2. Titin: 分子控制狂  |  Trinick, J. and Tskhovrebova, L. 1999. Trends Cell Biol. 9: 377-80. PMID: 10481174
  3. 骨骼肌 Z 盘的 Telethonin 和其他新蛋白质。  |  Faulkner, G., et al. 2001. IUBMB Life. 51: 275-82. PMID: 11699871
  4. Telethonin缺陷最初表现为先天性肌肉萎缩症。  |  Ferreiro, A., et al. 2011. Neuromuscul Disord. 21: 433-8. PMID: 21530252
  5. Telethonin 缺乏症与哺乳动物心脏对生物力学压力的适应不良有关。  |  Knöll, R., et al. 2011. Circ Res. 109: 758-69. PMID: 21799151
  6. 心肌细胞中 titin-cap 蛋白 telethonin 的磷酸化调控。  |  Candasamy, AJ., et al. 2014. J Biol Chem. 289: 1282-93. PMID: 24280220
  7. 丝氨酸 157 和 161 的磷酸化是保持肉瘤 Z 盘蛋白 Telethonin 的心脏表达水平和功能的必要条件  |  Lewis, HR., et al. 2021. Front Physiol. 12: 732020. PMID: 34566695
  8. Nesprin-2 是心肌细胞肌节中 telethonin 和 FHL-2 的新型支架蛋白。  |  Li, C., et al. 2024. J Biol Chem. 300: 107254. PMID: 38569934
  9. 作为支架和弹簧的 Titin。细胞骨架  |  Trinick, J. 1996. Curr Biol. 6: 258-60. PMID: 8805236
  10. Telethonin,一种新型的心脏和骨骼肌肉瘤蛋白。  |  Valle, G., et al. 1997. FEBS Lett. 415: 163-8. PMID: 9350988
  11. titin 的冲突。  |  Means, AR. 1998. Nature. 395: 846-7. PMID: 9804415
  12. 肌纤维生成过程中激活 titin 激酶结构域的结构基础  |  Mayans, O., et al. 1998. Nature. 395: 863-9. PMID: 9804419

订购信息

产品名称产品编号规格价格数量收藏夹

Telethonin 抗体 (G-11)

sc-25327
200 µg/ml
RMB2377.00

Telethonin (G-11): m-IgG Fc BP-HRP 套装

sc-528403
200 µg Ab; 10 µg BP
RMB2662.00

Telethonin (G-11): m-IgGκ BP-HRP 套装

sc-520776
200 µg Ab, 40 µg BP
RMB2662.00

Telethonin (G-11): m-IgG1 BP-HRP 套装

sc-542915
200 µg Ab; 20 µg BP
RMB2662.00

Telethonin 抗体 (G-11) AC

sc-25327 AC
500 µg/ml, 25% agarose
RMB3129.00

Telethonin 抗体 (G-11) HRP

sc-25327 HRP
200 µg/ml
RMB2377.00

Telethonin 抗体 (G-11) FITC

sc-25327 FITC
200 µg/ml
RMB2482.00

Telethonin 抗体 (G-11) PE

sc-25327 PE
200 µg/ml
RMB2580.00

Telethonin 抗体 (G-11) Alexa Fluor® 488

sc-25327 AF488
200 µg/ml
RMB2685.00

Telethonin 抗体 (G-11) Alexa Fluor® 546

sc-25327 AF546
200 µg/ml
RMB2685.00

Telethonin 抗体 (G-11) Alexa Fluor® 594

sc-25327 AF594
200 µg/ml
RMB2685.00

Telethonin 抗体 (G-11) Alexa Fluor® 647

sc-25327 AF647
200 µg/ml
RMB2685.00

Telethonin 抗体 (G-11) Alexa Fluor® 680

sc-25327 AF680
200 µg/ml
RMB2685.00

Telethonin 抗体 (G-11) Alexa Fluor® 790

sc-25327 AF790
200 µg/ml
RMB2685.00

Can Telethonin (G-11): sc-25327 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Telethonin (G-11): sc-25327 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2021-05-13
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Rated 5 out of 5 by from Strong detectionThis antibody will perform as desired in blotting and staining procedures. It has great reactivity and has been used to publish several times.
Date published: 2017-02-06
Rated 5 out of 5 by from This antibody produced good results for immunostainingThis antibody produced good results for immunostaining of freshly isolated ventricular adult mouse cardiomyocytes fixed with paraformaldehyde.
Date published: 2015-10-07
Rated 5 out of 5 by from Great Immunoperoxidase staining of formalin fixedGreat Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes. - SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Specific bands and good signal by WesternSpecific bands and good signal by Western blot analysis of Telethonin expression in rat skeletal muscle, mouse heart and rat heart tissue extracts. - SCBT QC
Date published: 2015-04-22
Rated 5 out of 5 by from Positive immunofluorescence staining of methanolPositive immunofluorescence staining of methanol-fixed Sol8 cells - SCBT QC
Date published: 2015-04-17
Rated 5 out of 5 by from Robust immunoperoxidase staining of formalin fixedRobust immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue. - SCBT QC
Date published: 2015-03-22
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Telethonin 抗体 (G-11) is rated 5.0 out of 5 by 6.
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