Date published: 2025-9-7

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TDAG51 抗体 (RN-6E2): sc-23866

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说明书
  • TDAG51 抗体 RN-6E2 是小鼠单克隆 IgG2a κ,TDAG51抗体, 在38篇文献中引用,规格为200 µg/ml
  • 免疫human物种的TDAG51
  • TDAG51 抗体 (RN-6E2) 推荐用于 WB, IP, IF, IHC(P) 和 FCM,检测mouse, rat 和human 来源的 TDAG51
  • 抗TDAG51抗体(RN-6E2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取TDAG51 (RN-6E2): sc-23866免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRPm-IgGκ BP-HRP 是 TDAG51 抗体 (RN-6E2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与TDAG51 抗体 (RN-6E2) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

TDAG51抗体(RN-6E2)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和流式细胞术(FCM)检测小鼠、大鼠和人类来源的TDAG51蛋白。抗TDAG51抗体(RN-6E2)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。TDAG51,又称Pleckstrin Homology Like Domain Family A Member 1,在调节T细胞凋亡方面发挥着关键作用,而T细胞凋亡对于维持免疫平衡和预防自身免疫至关重要。TDAG51主要位于T细胞的细胞质和细胞核中,参与将T细胞受体刺激与FAS受体表达(凋亡过程中的关键因素)联系起来的信号通路。TDAG51通过恢复失去FAS表达能力的T细胞的激活诱导凋亡,在免疫反应中发挥关键调解作用。TDAG51在调节凋亡方面的作用凸显了其在免疫监视和免疫反应整体调节中的重要性,使其成为免疫学和癌症治疗研究的重要靶标。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TDAG51 抗体 (RN-6E2) 参考文献:

  1. TDAG51对于Fas/CD95调节和体内细胞凋亡不是必需的。  |  Rho, J., et al. 2001. Mol Cell Biol. 21: 8365-70. PMID: 11713273
  2. 穿孔素在淋巴细胞介导的细胞溶解中的作用  |  Yagita, H., et al. 1992. Adv Immunol. 51: 215-42. PMID: 1502975
  3. 穿孔素在细胞溶解中的核心作用?  |  Podack, ER., et al. 1991. Annu Rev Immunol. 9: 129-57. PMID: 1910674
  4. 淋巴细胞介导的依赖和不依赖穿孔素的细胞毒性途径。  |  Young, JD., et al. 1988. Immunol Rev. 103: 161-202. PMID: 3292393
  5. TDAG51缺乏症 肾小球足细胞通过AKT-GSK-3β通路激活Nrf2,从而免受高糖诱导的损伤。  |  Liu, C., et al. 2022. Inflammation. 45: 1520-1533. PMID: 35175494
  6. TDAG51通过SREBP-1/ANGPTL8通路减轻妊娠糖尿病患者的脂质代谢障碍和胰岛素抵抗。  |  Wu, X. and Xiao, B. 2023. Balkan Med J. 40: 175-181. PMID: 36960944
  7. TDAG51在LPS诱导的炎症反应中促进转录因子FoxO1的活性。  |  Park, ES., et al. 2023. EMBO J. 42: e111867. PMID: 37203866
  8. 肝细胞中ER应激反应蛋白TDAG51的恢复可减轻小鼠的非酒精性脂肪肝。  |  Yousof, TR., et al. 2024. J Biol Chem. 300: 105655. PMID: 38237682
  9. 淋巴细胞介导的细胞毒性机制。  |  Henkart, PA. 1985. Annu Rev Immunol. 3: 31-58. PMID: 3904772
  10. Fas 及其配体在 T 细胞介导的细胞毒性的一般机制中的作用。  |  Hanabuchi, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 4930-4. PMID: 7515183
  11. Fas 蛋白在正常小鼠的 CD4+CD8+ 胸腺细胞和活化的成熟淋巴细胞上高水平表达,但在狼疮易感株 MRL lpr/lpr 中却没有表达。  |  Drappa, J., et al. 1993. Proc Natl Acad Sci U S A. 90: 10340-4. PMID: 7694292
  12. 在活化诱导的细胞死亡中将 TCR 信号与 Fas(CD95) 表达结合起来的新型基因产物。  |  Park, CG., et al. 1996. Immunity. 4: 583-91. PMID: 8673705

订购信息

产品名称产品编号规格价格数量收藏夹

TDAG51 抗体 (RN-6E2)

sc-23866
200 µg/ml
RMB2377.00

TDAG51 (RN-6E2): m-IgG Fc BP-HRP 套装

sc-528373
200 µg Ab; 10 µg BP
RMB2662.00

TDAG51 (RN-6E2): m-IgGκ BP-HRP 套装

sc-520735
200 µg Ab, 40 µg BP
RMB2662.00

TDAG51 (RN-6E2): m-IgG2a BP-HRP 套装

sc-547079
200 µg Ab; 10 µg BP
RMB2662.00

TDAG51 抗体 (RN-6E2) AC

sc-23866 AC
500 µg/ml, 25% agarose
RMB3129.00

TDAG51 抗体 (RN-6E2) HRP

sc-23866 HRP
200 µg/ml
RMB2377.00

TDAG51 抗体 (RN-6E2) FITC

sc-23866 FITC
200 µg/ml
RMB2482.00

TDAG51 抗体 (RN-6E2) PE

sc-23866 PE
200 µg/ml
RMB2580.00

TDAG51 抗体 (RN-6E2) Alexa Fluor® 488

sc-23866 AF488
200 µg/ml
RMB2685.00

TDAG51 抗体 (RN-6E2) Alexa Fluor® 546

sc-23866 AF546
200 µg/ml
RMB2685.00

TDAG51 抗体 (RN-6E2) Alexa Fluor® 594

sc-23866 AF594
200 µg/ml
RMB2685.00

TDAG51 抗体 (RN-6E2) Alexa Fluor® 647

sc-23866 AF647
200 µg/ml
RMB2685.00

TDAG51 抗体 (RN-6E2) Alexa Fluor® 680

sc-23866 AF680
200 µg/ml
RMB2685.00

TDAG51 抗体 (RN-6E2) Alexa Fluor® 790

sc-23866 AF790
200 µg/ml
RMB2685.00

Can I use this mouse monoclonal antibody for immunohistochemical staining of mouse tissue?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes. We recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is currently available conjugated to phycoerythrin (sc-23866 PE) or fluoroscein (sc-23866 FITC), Alexa Fluor® 488 (sc-23866 AF488) or Alexa Fluor® 647 (sc-23866 AF647). Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-04
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Rated 1 out of 5 by from No or weak staining for IHC-PI performed IHC-P with this antibody on BondMax (Leica), and this section (esophagus and squamous cell carcinoma of esophagus) shows no or weak staining in the stratified squamous epithelium.
Date published: 2022-10-25
Rated 4 out of 5 by from IHCThis antibody worked well for immunohistochemistry on brain sections.
Date published: 2021-06-25
Rated 5 out of 5 by from Very good AbWe tested it for western blotting and for IF on formalin-fixed paraffin-embeded sections.
Date published: 2019-04-15
Rated 5 out of 5 by from envisionedIt is envisioned that cytotoxic T lymphocyte-mediated cytotoxicity constitutes an important part of the mechanism of specific effects in immune surveillance against cells infected or transformed by a virus.
Date published: 2017-02-09
Rated 5 out of 5 by from Versitle AntibodyClean and specific results by Western blot, IHC (P), IF and flow cytometry. Highly recommended!
Date published: 2017-01-10
Rated 5 out of 5 by from Wh and ihc great!!Just a great antibody for western blot and ihc applications
Date published: 2016-12-31
Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human esophagus tissue. -SCBT QC
Date published: 2015-04-24
Rated 4 out of 5 by from Used for WB on mouse samplesUsed for WB on mouse samples
Date published: 2015-04-08
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TDAG51 抗体 (RN-6E2) is rated 4.4 out of 5 by 11.
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