Date published: 2025-9-7
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TCR δ 抗体 (H-41): sc-100289

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说明书
  • TCR delta 抗体 H-41 是小鼠单克隆 IgG1 κ，TCR δ抗体, 在34篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组TCR δ
  • 推荐用于 human 来源的TCR δ WB, IP 和 ELISA检测
  • 关于如何获取TCR δ (H-41): sc-100289的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP是TCR δ Antibody (H-41) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与TCR δ Antibody (H-41) 搭配使用（请参阅下面的订购信息）。

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研究信息

関連項目

额外TCR抗体，包括TCR α, TCR β, TCR C β 1, TCR δ, TCR γ, TCR V α 24 J α 18, TCR V α 8, TCR V β 11, TCR V β 13.1, TCR V β 13.2, TCR V β 16, TCR V β 4, TCR V β 5, TCR V β 7, TCR V β 8.1-2和TCR V β 8.1-3

TCRδ抗体（H-41）是一种小鼠单克隆IgG1κ轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测人源TCRδ蛋白。抗TCR delta抗体（H-41）以非结合形式提供。T细胞抗原受体（TCR）通过识别外来抗原并启动激活T细胞的细胞内信号传导，从而在免疫反应中发挥关键作用，使T细胞从休眠状态转变为活跃状态。TCR是由α和β或γ和δ链组成的异二聚体，大多数T细胞（约95%）表达α/β异二聚体，而较小部分（约2-5%）表达γ/δ异二聚体。TCR delta (H-41) 抗体在辅助性T细胞和细胞毒性T细胞上表达，可通过其CD4和CD8共受体的表达来区分。CD4是一种膜糖蛋白，具有四个细胞外免疫球蛋白样结构域，可增强TCR与抗原呈递细胞呈递的II类主要组织相容性复合物（MHC）分子之间的相互作用，从而提高免疫反应的亲和力。了解TCR的结构和功能，包括其与CD4的相互作用，对于开发靶向免疫疗法和提高疫苗功效至关重要，这使得TCR delta单克隆抗体（H-41）成为研究人员研究T细胞活化和免疫反应的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TCR δ 抗体 (H-41) 参考文献:

  1. 新型抗 CD4 单克隆抗体将人类免疫缺陷病毒感染和 CD4+ 细胞融合与病毒结合分离开来。  |  Healey, D., et al. 1990. J Exp Med. 172: 1233-42. PMID: 1698911
  2. 具有不变γδ抗原受体的 T 细胞的免疫生物学。  |  Allison, JP. and Havran, WL. 1991. Annu Rev Immunol. 9: 679-705. PMID: 1832874
  3. T 细胞抗原受体的信号转导。  |  Weiss, A., et al. 1991. Semin Immunol. 3: 313-24. PMID: 1839225
  4. 确定人类 CD4 中与 HIV 结合的关键残基。  |  Arthos, J., et al. 1989. Cell. 57: 469-81. PMID: 2541915
  5. 人类和小鼠 T4 基因的结构和表达。  |  Maddon, PJ., et al. 1987. Proc Natl Acad Sci U S A. 84: 9155-9. PMID: 3501122
  6. CD4 与 MHC II 类分子之间的相互作用及其对 T 细胞功能的影响。  |  Vignali, DA. 1994. Behring Inst Mitt. 133-47. PMID: 7998907
  7. T 细胞受体与肽/主要组织相容性复合体（MHC）和超抗原/MHC 配体的相互作用受抗原支配。  |  Ehrich, EW., et al. 1993. J Exp Med. 178: 713-22. PMID: 8393480
  8. CD4 和 CD8 作为共同受体在抗原受体信号传导中的不同作用。  |  Julius, M., et al. 1993. Immunol Today. 14: 177-83. PMID: 8499078

订购信息

产品名称产品编号规格价格数量收藏夹

TCR δ 抗体 (H-41)

sc-100289
100 µg/ml
RMB2504.00

TCR δ (H-41): m-IgG Fc BP-HRP 套装

sc-539681
100 µg Ab; 10 µg BP
RMB2662.00

Hello, Can this clone H-41 be conjugated to a fluorophore? I seem to find it only unconjugated. Thank you for your reply.

Asked by: Karine
Thank you for your question. TCR δ Antibody (H-41): sc-100289 is only available as an unconjugated product. Since it is supplied with gelatin and sodium azide in its buffer, downstream conjugation is not viable.
Answered by: Tech Support Europe
Date published: 2025-05-09

hi, does this Ab recognize Vdelta 1 or Vdelta2 chain? What is the epitope recognized? Please don't ask me to call your tec support. Thanks!

Asked by: CD21701
Thank you for your question. please see link :https://www.uniprot.org/uniprotkb/B7Z8K6/entry
Answered by: BlakeJ
Date published: 2023-11-16

Product sc-100289, H41 antibody,contains gelatin. What is the gelatin? Is this a protein or mix of proteins?

Asked by: Jimk
Thank you for your question . Gelatin is used as a stabilizer and it keeps antibody in solution. To request an antibody without gelatin please contact [email protected]
Answered by: BlakeJ
Date published: 2023-01-19

As per your data, this clone detects TCR delta chain protein in HeLa and K562 cells which are not gamma-delta T cells. Are these cell lines transfected with delta chain expressing constructs ?

Asked by: rnahar
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801. ext.1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-10-18

Does the antibody bind to constant region of delta chain? what's the epitope ?

Asked by: rnahar
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801. ext.1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-10-18

Does this antibody work in mouse tissues?

Asked by: Tero
Thank you for your question. Anti-TCR δ Antibody (H-41): sc-100289 is only recommended for detection of TCR δ of human origin by WB, IP and ELISA.
Answered by: Tech Support Europe
Date published: 2023-06-23

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Service 11
Date published: 2017-02-03
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Rated 5 out of 5 by from Ottimo funzionamentoL'anticorpo performa molto bene alla condizione, da noi messa a punto per IHC, 1:50 ph9 con incubazione di 1h30 a RT
Date published: 2023-03-08
Rated 5 out of 5 by from ottimo funzionamentoAnticorpo ben performante anche in IHC alla condizione 1:50 ph9 incubato 90' a RT.
Date published: 2023-02-07
Rated 5 out of 5 by from パラフィン切片の免疫染色で綺麗に染まります通常のパラフィン切片で、EDTAph8.0で圧力鍋を使用し、陽性コントロールがとてもよく染まりました。
Date published: 2021-04-08
Rated 5 out of 5 by from Very good TCRgd+ cell staining on FFPEAfter TCR gamma.20 (from Thermo Scientific) being discontinued, finally I've found in Santa Cruz Biotechnology TCR delta a solid antibody useful to recognize TCRgd cells in formalin-fixed paraffin embedded sample using immunohistochemistry. I've stained sections from tonsil and small intestine with a range of dilution from 1:25 to 1:250 and I've achieved strong and tidy stainings in all dilutions tested. Also antigen unmasking is very tolerant. It works using EDTA pH8.0 or Citrate pH 6.0 in microwave or water bath. I'm very satisfied from the results
Date published: 2020-03-12
Rated 5 out of 5 by from Excellent staining for IHC on FFPE tissuesI successfully used this product for immunohistochemistry on 4 micron sections of FFPE tonsil tissues and FFPE cell block of a bone marrow blood clot. I got excellent results using 1:50-1:100 dilution for 1 hour incubation at room temperature manually or using the Ventena Benchmark Ultra autostainer. The best results were obtained using EDTA pH9 in a steamer then placed on the autostainer, or alternately using CC1 at 99 degrees C for 36 minutes. Ventena Ultraview/DAB was used for the detection system.
Date published: 2018-06-19
Rated 5 out of 5 by from Clean and Great expression of TCR Delta.I struggled for over a year to find a replacement for TCR Gamma, which was discontinued by Thermo last year. This is a great replacement for it. I can't upload a TIFF image, but the examples that I wanted to upload were from a Spleen and Colon. The retrieval for Leica Bond III was Hier2 for 40 minutes with 15 minutes of antibody incubation (modified F Protocol). Dilution that worked best was 1:200 (using Leica's diluent).
Date published: 2017-12-20
Rated 5 out of 5 by from Good for human detectionPositive signal obtained at predicted molecular weight in WB for TCR delta.
Date published: 2017-02-07
Rated 3 out of 5 by from Faint band at correct MW in HeLa whole cell lysateFaint band at correct MW in HeLa whole cell lysate. -SCBT QC
Date published: 2013-12-12
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TCR δ 抗体 (H-41) is rated 4.8 out of 5 by 8.
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