Date published: 2025-9-7

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TBX3 抗体 (A-6): sc-166623

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说明书
  • TBX3 抗体 A-6 是小鼠单克隆 IgM κ,TBX3抗体, 在4篇文献中引用,规格为200 µg/ml
  • 针对氨基酸320-411的图谱,在TBX3的内部区域,human起源
  • 推荐用于 mouse, rat 和 human 来源的TBX3 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-166623 X, 200 µg/0.1 ml)
  • 关于如何获取TBX3 (A-6): sc-166623免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是TBX3 Antibody (A-6) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与TBX3 Antibody (A-6) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

TBX3抗体(A-6)是一种IgM κ小鼠单克隆TBX3抗体(也被指定为TBX3抗体、T-box 3抗体、T-box转录因子3抗体、转录抑制因子TBX3抗体、尺骨乳腺综合征(UMS)抗体或膀胱癌相关蛋白(XHL)抗体),可通过WB, IP, IF和ELISA检测小鼠、大鼠和人源的TBX3蛋白。TBX3抗体(A-6)为非偶联抗TBX3抗体。T-box(Tbx)基序存在于一个基因家族中,其结构特征和表达模式支持它们参与发育基因调控。Tbx基因家族在后生动物进化过程中大部分是保守的,这些基因编码推定的转录因子,这些转录因子共享一个独特定义的DNA结合域。Tbx基因是一个包含20多个成员的发育调控因子家族,最近在无脊椎动物和脊椎动物中被鉴定出来。Tbx基因的突变与多种人类疾病的发病有关。我们对Tbx产物功能机制的理解主要来自原型T/Brachyury,它是一种转录激活因子。Tbx基因构成了一个转录调控基因家族,涉及从胚层的形成到中枢神经系统组织模式的形成等各种发育过程。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TBX3 抗体 (A-6) 参考文献:

  1. 斑马鱼 tbx-c 在中线结构形成过程中的功能  |  Dheen, T., et al. 1999. Development. 126: 2703-13. PMID: 10331981
  2. 章鱼 ET 及其人类直向同源物 TBX3 对转录的抑制,该基因与尺侧乳腺综合征有关。  |  He, Ml., et al. 1999. Proc Natl Acad Sci U S A. 96: 10212-7. PMID: 10468588
  3. 斑马鱼胚胎发育过程中 Tbx5 的发育调控。  |  Begemann, G. and Ingham, PW. 2000. Mech Dev. 90: 299-304. PMID: 10640716
  4. tbx20,一种在斑马鱼颅运动神经元和发育中的心血管结构中表达的新脊椎动物 T-box 基因。  |  Ahn, DG., et al. 2000. Mech Dev. 95: 253-8. PMID: 10906473
  5. Tbx3 在干细胞和癌症发展中的特殊干性功能。  |  Dong, L., et al. 2019. Semin Cancer Biol. 57: 105-110. PMID: 30268432
  6. TBX3 在发育和疾病中的作用和调控。  |  Khan, SF., et al. 2020. Gene. 726: 144223. PMID: 31669645
  7. 在肝癌发生过程中,TBX3 在活化的 CTNNB1 突变体下游发挥肿瘤抑制因子的功能。  |  Liang, B., et al. 2021. J Hepatol. 75: 120-131. PMID: 33577921
  8. 从人类多能干细胞高效生成 TBX3+ 房室传导样心肌细胞。  |  Du, R., et al. 2023. Biochem Biophys Res Commun. 669: 143-149. PMID: 37271026
  9. 发育转录因子 TBX3 的蛋白静态再激活驱动了 BRAF/MAPK 介导的肿瘤发生。  |  Zhang, Z., et al. 2024. Nat Commun. 15: 4108. PMID: 38750011
  10. 过表达 TBX3 可抑制实验性胆管癌和人类胆管癌的肿瘤发生。  |  Deng, S., et al. 2024. Cell Death Dis. 15: 441. PMID: 38909034
  11. 人类 TBX2 同源物(一个保守的发育基因家族的成员)的鉴定, 表征以及在染色体 17q21-22 上的定域。  |  Law, DJ., et al. 1995. Mamm Genome. 6: 793-7. PMID: 8597636
  12. T-Box基因家族新成员TBX15的克隆, 绘图和表达分析。  |  Agulnik, SI., et al. 1998. Genomics. 51: 68-75. PMID: 9693034

订购信息

产品名称产品编号规格价格数量收藏夹

TBX3 抗体 (A-6)

sc-166623
200 µg/ml
RMB2377.00

TBX3 (A-6): m-IgGκ BP-HRP 套装

sc-551078
200 µg Ab; 40 µg BP
RMB2662.00

TBX3 抗体 (A-6) X

sc-166623 X
200 µg/0.1 ml
RMB2377.00

Good morning,  I would like to get a trial size for a few of your antibodies. (marked with S)  How do I go about ordering these?  thank you Stephanie 

Asked by: Anonymous
Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Tech Service
Date published: 2019-10-08

When should the TransCruz reagent sc-166623 X be used instead of the standard form sc-166623?

Asked by: Cweed
Thank you for your question. We recommend using the TransCruz reagent form when performing ChIP or GelShift assays. This form can also be used in other applications such as Western Blot or IHC, but the dilution should be adjusted by a factor of 10 to account for the higher original concentration.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 2 out of 5 by from Results are not convincingSeem to show non-specific staining on adrenal gland.
Date published: 2025-04-04
Rated 1 out of 5 by from anti Tbx3 A-6 mAb(SC-166623)I have used the antiTbx3 (A-6) mAb Ab in IF experimens on criosections of mouse hearts. The hears had been fixed 1h in PFA 1% on ice; the Ab has been incubated ON @+4C, secondary Ab was anti mouse IgG/I/M 1:400. The antibody did not show any reaction in the dilution range 1:10-1:.50. the sam
Date published: 2020-10-05
Rated 2 out of 5 by from not goodwork well in WB at 1:400,but the result is not good
Date published: 2017-08-31
Rated 5 out of 5 by from Produced nice Western blot data of TBX3 expressionProduced nice Western blot data of TBX3 expression in L428 and JAR whole cell lysates, U-698-M nuclear extract and mouse placenta tissue extract . -SCBT QC
Date published: 2014-02-11
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TBX3 抗体 (A-6) is rated 2.5 out of 5 by 4.
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