Date published: 2025-9-11

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TBK1 抗体 (6D603): sc-73115

4.5(6)
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说明书
  • TBK1 抗体 6D603 是小鼠单克隆 IgG1, 在5篇文献中引用,提供 50 µg/500 µl
  • 与human的TBK1的氨基酸563-577对应的合成肽杂交
  • 推荐用于 mouse, rat, human, bovine 和 canine 来源的TBK1 WB 和 IP检测
  • 目前,我们还没有完成TBK1 抗体 (6D603)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

TBK1抗体(6D603)是一种小鼠单克隆IgG1抗体,可通过蛋白质印迹(WB)和免疫沉淀(IP)检测小鼠、大鼠、人、牛和犬样本中的TBK1。TBK1或TANK结合激酶1在NFkB信号传导途径的调节中起着至关重要的作用,而NFkB信号传导途径对于免疫反应和炎症至关重要。TBK1主要位于细胞质中,与各种信号分子相互作用,调节NFkB的激活。TBK1的细胞质定位使其能够快速响应细胞应激和炎症信号,促进IkB蛋白的磷酸化并促进IkBα的降解,从而使NFkB能够转移到细胞核并启动靶基因的转录。TBK1的活性涉及多种疾病,包括癌症和自身免疫性疾病,因此TBK1成为治疗干预的重要靶点。抗TBK1抗体(6D603)是研究NFkB激活复杂机制及其在细胞信号通路中更广泛影响的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TBK1 抗体 (6D603) 参考文献:

  1. 系统性 RNA 干扰显示,KRAS 驱动的致癌癌症需要 TBK1。  |  Barbie, DA., et al. 2009. Nature. 462: 108-12. PMID: 19847166
  2. TBK1和IKKε通过RIPK1磷酸化防止TNF诱导的细胞死亡。  |  Lafont, E., et al. 2018. Nat Cell Biol. 20: 1389-1399. PMID: 30420664
  3. TBK1 磷酸化的 RAB7A 可通过 PINK-PARKIN 途径促进有丝分裂。  |  Heo, JM., et al. 2018. Sci Adv. 4: eaav0443. PMID: 30627666
  4. STING 与 TBK1 结合及被 TBK1 磷酸化的结构基础  |  Zhang, C., et al. 2019. Nature. 567: 394-398. PMID: 30842653
  5. 人类 TBK1 缺乏症会导致 TNF 诱导的细胞死亡引发自身炎症。  |  Taft, J., et al. 2021. Cell. 184: 4447-4463.e20. PMID: 34363755
  6. TBK1 在癌症发病机制和抗癌免疫中的作用。  |  Runde, AP., et al. 2022. J Exp Clin Cancer Res. 41: 135. PMID: 35395857
  7. AMPK 直接使 TBK1 磷酸化,从而将葡萄糖感应整合到先天性免疫中。  |  Zhang, Q., et al. 2022. Mol Cell. 82: 4519-4536.e7. PMID: 36384137
  8. 线粒体相关膜塌陷会损害 ALS 中 TBK1 介导的蛋白静态应激反应。  |  Watanabe, S., et al. 2023. Proc Natl Acad Sci U S A. 120: e2315347120. PMID: 37967220
  9. PTK2B 可促进 TBK1 和 STING 的寡聚化,并增强 STING-TBK1 信号传导。  |  Lin, Y., et al. 2023. Nat Commun. 14: 7567. PMID: 37989995
  10. NAK 相关蛋白 1/NAP1 激活 TBK1,以确保有丝分裂和细胞分裂的准确性。  |  Paul, S., et al. 2024. J Cell Biol. 223: PMID: 38059900

订购信息

产品名称产品编号规格价格数量收藏夹

TBK1 抗体 (6D603)

sc-73115
50 µg/500 µl
RMB2377.00

I am using TBK1 (6D603): sc-73115 antibody for immunoprecipitation, how much antibody should I use?

Asked by: Cweed
Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from High qualityI used this product a couple of days ago and it was fantastic. Very good product!
Date published: 2021-10-07
Rated 2 out of 5 by from Very weak antibodyGive a right size band in RAW264.7 cell lysates, but the signal is too weak.
Date published: 2017-11-30
Rated 5 out of 5 by from Great for Western blotObserved nice strong bands across multiple samples with TBK1 Antibody (6D603)
Date published: 2017-01-19
Rated 5 out of 5 by from Strong bands detected in WB using RAW 264Strong bands detected in WB using RAW 264.7 and KNRK whole cell lysates. -SCBT QC
Date published: 2015-07-11
Rated 5 out of 5 by from Good bands seen in WB using MCF7Good bands seen in WB using MCF7, THP-1, NTERA-2 cl.D1 and Jurkat whole cell lysates. -SCBT QC
Date published: 2015-04-10
Rated 5 out of 5 by from WB publishable data with human HEK293WB publishable data with human HEK293 - SCBT Publication Review
Date published: 2013-11-20
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TBK1 抗体 (6D603) is rated 4.5 out of 5 by 6.
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