Taurocholic Acid (CAS 81-24-3)

外观 :

Crystalline or powder

物理状态 :

Solid

溶解度 :

Soluble in water, hot alcohol, ethyl acetate (slightly), and ether.

保存 :

Store at 4° C

熔点 :

125° C

密度 :

~1.3 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.57 (Predicted)

光学活性 :

α18_D +38.8, c = 0.002 in alcohol

IC50 :

Plasmodium falciparum: IC₅₀ = 3.16 µM; Bile acid transporter: IC₅₀ = 5.3 µM (human); Bile acid transporter: IC₅₀ = 6.0 µM (rat); Multidrug resistance associated protein: IC₅₀ = 40.0 µM (human); Multidrug resistance-associated protein 4: IC₅₀ = 250 µM (human)

Ki 数据 :

Solute carrier organic anion transporter family member 1A1: K_i= 10.8 µM (rat); Solute carrier organic anion transporter family member 1A4: K_i= 39.4 µM (rat); Ileal bile acid transporter: K_i= 41.5 µM (human); Solute carrier organic anion transporter family member 1C1: K_i= 109 µM (rat); Solute carrier organic anion transporter family member 1A3: K_i= 183 µM (rat)

pK值 :

pK_a: 1.42 (Predicted)

PubChem CID :

Merck 索引 :

14: 9075

MDL 号码 :

MFCD00053458

SMILES :

C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C