Date published: 2026-10-24

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Talin-1 Antibody (YQ-16) - Western Blotting - Image 33458
Talin-1 抗体 (YQ-16): sc-81805. 对 Raw 264. 7 全细胞裂解液中 Talin-1 的表达进行 Western 印迹分析.
Talin-1 Antibody (YQ-16) - Western Blotting - Image 33458
Talin-1 抗体 (YQ-16): sc-81805. 对 Raw 264. 7 全细胞裂解液中 Talin-1 的表达进行 Western 印迹分析.
Talin-1 Antibody (YQ-16) - Immunohistochemistry - Image 35893
Talin-1 抗体 (YQ-16): sc-81805. 福尔马林固定, 石蜡包埋的人胃组织的免疫过氧化物酶染色, 显示膜和细胞质定位.
Talin-1 抗体 (YQ-16): sc-81805. 对 Raw 264. 7 全细胞裂解液中 Talin-1 的表达进行 Western 印迹分析.

Talin-1 抗体 (YQ-16): sc-81805

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说明书
  • Talin-1抗体(YQ-16)是小鼠单克隆IgG3 κ, 在8篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组Talin-1
  • 推荐用于 mouse, rat 和 human 来源的Talin-1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Talin (C-9): sc-365875，可查看有标记的 Talin-1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成Talin-1 抗体 (YQ-16)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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粘着斑被确定为组织培养细胞质膜内的区域，这些区域紧密粘附于下面的基质。在体内，这些区域参与细胞与细胞外基质的粘附。桩蛋白和纽蛋白是细胞骨架、粘着斑蛋白，它们是将肌动蛋白网络与质膜连接起来的蛋白质复合物的组成部分。已经在其他细胞骨架蛋白上鉴定出纽蛋白结合位点，包括Talin-1和α-辅肌动蛋白。此外，纽蛋白、Talin-1、Talin-2和α-辅肌动蛋白各自含有肌动蛋白结合位点。已经显示纽蛋白、Talin-1和Talin-2的表达受到肌动蛋白表达水平的影响。已经显示α-辅肌动蛋白通过与纽蛋白和Talin复合物的相互作用或通过与整合素的直接相互作用将肌动蛋白连接到质膜中的整合素。Talin-2与Talin-1相似，但显示出不同的表达模式，不能补偿Talin-1的缺少。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Talin-1 抗体 (YQ-16) 参考文献:

  1. 整合素通过 talin 和 vinculin 与细胞骨架连接。  |  Ziegler, WH., et al. 2008. Biochem Soc Trans. 36: 235-9. PMID: 18363566
  2. 整合素激活和血细胞功能的 Rap1-RIAM-talin 轴。  |  Lagarrigue, F., et al. 2016. Blood. 128: 479-87. PMID: 27207789
  3. 受力的整合素-talin复合体。  |  Neumann, J. and Gottschalk, KE. 2016. Protein Eng Des Sel. 29: 503-512. PMID: 27737925
  4. Talin-1 是整合素活化的主要血小板 Rap1 效应器。  |  Lagarrigue, F., et al. 2020. Blood. 136: 1180-1190. PMID: 32518959
  5. 与癌症相关的talin点突变会破坏细胞粘附和迁移。  |  Azizi, L., et al. 2021. Sci Rep. 11: 347. PMID: 33431906
  6. Talin 的机械敏感性受与细胞周期蛋白依赖性激酶-1 的直接相互作用调节。  |  Gough, RE., et al. 2021. J Biol Chem. 297: 100837. PMID: 34118235
  7. 癌症生物学：缺氧诱导的talin尾对接引发癌症转移。  |  Strömblad, S. 2022. Curr Biol. 32: R79-R81. PMID: 35077693
  8. Tensin3 与 talin 的相互作用推动了纤维粘连蛋白相关纤维粘连的形成。  |  Atherton, P., et al. 2022. J Cell Biol. 221: PMID: 36074065
  9. AGK通过影响Talin-1和αⅡbβ3介导的双向信号通路促进动脉血栓形成  |  Zhang, P., et al. 2023. Arterioscler Thromb Vasc Biol. 43: 1015-1030. PMID: 37051931
  10. 钙蛋白酶通过裂解Talin促进LPS诱导的肺内皮屏障功能障碍  |  Song, L., et al. 2023. Am J Respir Cell Mol Biol. 69: 678-688. PMID: 37639326

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产品名称产品编号规格价格数量收藏夹

Talin-1 抗体 (YQ-16)

sc-81805
100 µg/ml
CNY2550.00

Which region of Talin-1 does sc-81805 Talin-1 antibody recognize?

Asked by: MB_KUL
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-04-20

Can sc-81805: Talin-1 (YQ-16) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Cweed
Thank you for your question. Yes, sc-81805: Talin-1 (YQ-16) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by Mtb lab from Western Blotting with this antibody works wellWe purchased this antibody and used it for western blotting to detect Talin in the cell lysate, which worked well.
Date published: 2020-01-21
Rated 4 out of 5 by JT from Publishable data in WB using pig VascularPublishable data in WB using pig Vascular smooth muscle cells -SCBT Publication Review
Date published: 2015-05-19
Rated 4 out of 5 by JM from Publishable data in IP using human synovialPublishable data in IP using human synovial cells -SCBT Publication Review
Date published: 2015-04-14
Rated 4 out of 5 by JT from Great immunoperoxidase membrane and cytoplasmicGreat immunoperoxidase membrane and cytoplasmic staining in formalin-fixed, paraffin-embedded human stomach tissue. -SCBT QC
Date published: 2015-04-12
Rated 4 out of 5 by TS from Nice band seen in WB using Raw 264Nice band seen in WB using Raw 264.7 whole cell lysate. -SCBT QC
Date published: 2015-01-05
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Talin-1 抗体 (YQ-16) is rated 4.0 out of 5 by 5.
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