Date published: 2025-9-8

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T-Plastin 抗体 (A-3): sc-166208

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说明书
  • T-Plastin 抗体 A-3 是小鼠单克隆 IgG2b κ,T-Plastin抗体, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的T-Plastin的N-terminus的氨基酸482-516之间
  • T-Plastin 抗体 (A-3) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ,检测 mouse, rat, human 和 来源的T-Plastin; 也和以下物种反应,包括: 和 equine, porcine and avian
  • 抗T-Plastin抗体(A-3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取T-Plastin (A-3): sc-166208免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRPm-IgGκ BP-HRP 是 T-Plastin 抗体 (A-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与T-Plastin 抗体 (A-3) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

T-Plastin抗体(A-3)是一种IgG2bκ小鼠单克隆T-Plastin单克隆抗体(也称为T-Plastin、Plastin-3抗体或PLS3抗体),通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人来源的T-Plastin蛋白。T-Plastin抗体(A-3)既有非偶联的抗T-Plastin的抗体形式,也有多种偶联的抗T-Plastin抗体形式,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。质体蛋白(菌毛蛋白)是肌动蛋白结合蛋白家族的成员,表现出组织特异性表达模式。L-和T-Plastin都已被证明参与细胞骨架重组。L-Plastin在造血细胞系中特异性表达,已被认为参与控制细胞粘附和运动。它经常在来源于乳腺实体瘤的细胞系中表达,并与癌症侵袭和转移有关。L-Plastin也在大多数来源于各种类型实体瘤的人类癌症细胞系中表达。此外,L-Plastin参与调节白细胞粘附,并且L-Plastin的磷酸化参与调节整合素调节信号通路。T-Plastin的独特之处在于它在许多类型的组织中表达,而在白细胞中明显不存在。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

T-Plastin 抗体 (A-3) 参考文献:

  1. 白细胞和非白细胞中人类 T-塑蛋白基因的差异调控:启动子, 增强子和 CpG 岛的鉴定。  |  Lin, CS., et al. 1999. DNA Cell Biol. 18: 27-37. PMID: 10025506
  2. 乳腺癌和前列腺癌细胞中睾酮对 L-弹性蛋白基因的上调:确定三个雄激素受体合作结合序列。  |  Lin, CS., et al. 2000. DNA Cell Biol. 19: 1-7. PMID: 10668786
  3. 正常和癌变乳腺组织中 L-弹性蛋白同工酶的表达模式。  |  Lapillonne, A., et al. 2000. Anticancer Res. 20: 3177-82. PMID: 11062740
  4. T-plastin在皮肤T细胞淋巴瘤中的诱导表达和病理生理功能。  |  Bégué, E., et al. 2012. Blood. 120: 143-54. PMID: 22627769
  5. 钙调神经磷酸酶/NFAT通路下游的T-plastin表达与角质细胞迁移有关。  |  Brun, C., et al. 2014. PLoS One. 9: e104700. PMID: 25226517
  6. 缺氧刺激膜转运需要T-plastin。  |  Wottawa, M., et al. 2017. Acta Physiol (Oxf). 221: 59-73. PMID: 28218996
  7. T-plastin对于基底膜组装和表皮形态发生至关重要。  |  Dor-On, E., et al. 2017. Sci Signal. 10: PMID: 28559444
  8. T-Plastin 可在细胞迁移过程中强化膜突起,弥合基质间隙。  |  Garbett, D., et al. 2020. Nat Commun. 11: 4818. PMID: 32968060
  9. T-plastin双向肌动蛋白交联的结构机制。  |  Mei, L., et al. 2022. Proc Natl Acad Sci U S A. 119: e2205370119. PMID: 36067297
  10. L-和T-plastin同工型之间的功能差异。  |  Arpin, M., et al. 1994. J Cell Biol. 127: 1995-2008. PMID: 7806577
  11. 肌动蛋白结合蛋白 L-弹性蛋白在调节白细胞整合素功能中的作用。  |  Jones, SL., et al. 1998. Proc Natl Acad Sci U S A. 95: 9331-6. PMID: 9689080
  12. 塑蛋白磷酸化分析和绘图。  |  Lin, CS., et al. 1998. DNA Cell Biol. 17: 1041-6. PMID: 9881671

订购信息

产品名称产品编号规格价格数量收藏夹

T-Plastin 抗体 (A-3)

sc-166208
200 µg/ml
RMB2377.00

T-Plastin (A-3): m-IgGκ BP-HRP 套装

sc-521533
200 µg Ab, 40 µg BP
RMB2662.00

T-Plastin (A-3): m-IgG2b BP-HRP 套装

sc-548922
200 µg Ab; 10 µg BP
RMB2662.00

T-Plastin 抗体 (A-3) AC

sc-166208 AC
500 µg/ml, 25% agarose
RMB3129.00

T-Plastin 抗体 (A-3) HRP

sc-166208 HRP
200 µg/ml
RMB2377.00

T-Plastin 抗体 (A-3) FITC

sc-166208 FITC
200 µg/ml
RMB2482.00

T-Plastin 抗体 (A-3) PE

sc-166208 PE
200 µg/ml
RMB2580.00

T-Plastin 抗体 (A-3) Alexa Fluor® 488

sc-166208 AF488
200 µg/ml
RMB2685.00

T-Plastin 抗体 (A-3) Alexa Fluor® 546

sc-166208 AF546
200 µg/ml
RMB2685.00

T-Plastin 抗体 (A-3) Alexa Fluor® 594

sc-166208 AF594
200 µg/ml
RMB2685.00

T-Plastin 抗体 (A-3) Alexa Fluor® 647

sc-166208 AF647
200 µg/ml
RMB2685.00

T-Plastin 抗体 (A-3) Alexa Fluor® 680

sc-166208 AF680
200 µg/ml
RMB2685.00

T-Plastin 抗体 (A-3) Alexa Fluor® 790

sc-166208 AF790
200 µg/ml
RMB2685.00

T-Plastin (A-3) 中和勝肽

sc-166208 P
100 µg/0.5 ml
RMB511.00

Have any of your T-plastin (plastin 3) antibodies been tested in ICC?

Asked by: Jessica2017
Thank you for your question. This antibody has been tested in formalin-fixed paraffin-embedded tissue sections. We have not yet tested the antibody in ICC, however, there is a publication citing use of the antibody for this application. Please reference PMID: 27559491 for more details.
Answered by: Technical Support
Date published: 2017-11-14

What application is the blocking peptide sc-166208 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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T-Plastin 抗体 (A-3) is rated 5.0 out of 5 by 3.
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