Syk Inhibitor II (CAS 227449-73-2)

物理状态 :

Solid

溶解度 :

Soluble in water (25 mg/ml), and DMSO (100 mg/ml).

保存 :

Store at 4° C

折射率 :

n²⁰_D ~1.63 (Predicted)

IC50 :

Syk: IC₅₀ = 41 nM; PKCε: IC₅₀ = 5.1 µM; PKCβII: IC₅₀ = 11 µM; ZAP-70: IC₅₀ = 11.2 µM; Btk: IC₅₀ = 15.5 µM; Itk: IC₅₀ = 22.6 µM; FcεRI-mediated 5-HT release: IC₅₀ = 460 nM (RBL-2H3 cells); Lysyl-tRNA synthetase: IC₅₀ = 41 nM (human)

PubChem CID :

SMILES :

C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)NCCN)C(F)(F)F.O.O.Cl.Cl