Date published: 2025-9-7

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Su[fu] 抗体 (F-4): sc-137014

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说明书
  • Su[fu] 抗体 F-4 是小鼠单克隆 IgG2a κ,Su[fu]抗体, 在7篇文献中引用,规格为200 µg/ml
  • 针对氨基酸185-484的抗原,在suppressor of fused的C-terminus处映射,融合human来源
  • Su[fu] 抗体 (F-4) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Su[fu] 54 kDa form (484 amino acid splice variant)
  • 抗Su[fu]抗体(F-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Su[fu] (F-4): sc-137014免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是Su[fu] Antibody (F-4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Su[fu] Antibody (F-4) 打包提供(请参阅下面的订购信息)。

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関連項目

Su(fu)抗体(F-4)是一种IgG2a κ小鼠单克隆Su抗体(也称为Hedgehog信号传导的SUFU负调节剂抗体,SUFUH抗体,Fused同源物抑制抗体或Hedgehog信号传导的负调节剂抗体),可通过WB,IP,IF和ELISA检测小鼠,大鼠和人源的Su蛋白。 Su(fu)抗体(F-4)既可以是非偶联的抗Su抗体形式,也可以是多种偶联形式的抗Su抗体,包括琼脂糖,HRP,PE,FITC和多种Alexa Fluor®偶联物。 Su(fu)(用于Fused抑制因子)是脊椎动物Hedgehog信号传导途径中的关键负调节剂。 Su(fu)与此信号传导途径中编码蛋白质的基因相互作用。在果蝇中,Hedgehog途径的细胞内转导涉及包含Su(fu)的大复合物的释放。 Su(fu)抑制转录因子Gli1的活性,并与Gli2,Gli3和丝氨酸/苏氨酸激酶Fused相互作用。 Su(fu)在成人和胚胎组织中广泛表达,在hedgehog信号传导的组织中表达较高。 Su(fu)基因位点定位于在胶质母细胞瘤,前列腺癌,恶性黑色素瘤和子宫内膜癌中被删除的区域。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Su[fu] 抗体 (F-4) 参考文献:

  1. 刺猬通过调节不同转录激活剂和抑制剂形式的幼鼠断肢的活动来控制肢体的发育。  |  Méthot, N. and Basler, K. 1999. Cell. 96: 819-31. PMID: 10102270
  2. 果蝇融合抑制因子的脊椎动物同源物与转录调节因子 gli 家族相互作用。  |  Pearse, RV., et al. 1999. Dev Biol. 212: 323-36. PMID: 10433824
  3. 哺乳动物融合抑制因子调节 Gli-1 的核-细胞质穿梭。  |  Kogerman, P., et al. 1999. Nat Cell Biol. 1: 312-9. PMID: 10559945
  4. 人类融合抑制因子的特征,它是锌指转录因子 Gli 的负调控因子。  |  Stone, DM., et al. 1999. J Cell Sci. 112 (Pt 23): 4437-48. PMID: 10564661
  5. 融合抑制因子负调控β-catenin 信号转导  |  Meng, X., et al. 2001. J Biol Chem. 276: 40113-9. PMID: 11477086
  6. Rab23 以依赖 Su(Fu) 的方式负向调节 Gli1 转录因子。  |  Chi, S., et al. 2012. Cell Signal. 24: 1222-8. PMID: 22365972
  7. 对结核分枝杆菌具有潜在活性的化合物。  |  Sao Emani, C., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29437626
  8. CTHRC1 与禽白血病病毒 J 亚群(ALV-J)的 SU 蛋白之间的相互作用促进了病毒复制。  |  Pang, Y., et al. 2019. Virus Res. 264: 32-39. PMID: 30797826
  9. 槲皮素纳米悬浮液通过刺猬信号通路对前列腺癌细胞株 LNCaP 的影响  |  Mousavi, N., et al. 2021. Rep Biochem Mol Biol. 10: 69-75. PMID: 34277870
  10. 捕捉刺猬的蛛丝马迹  |  Ruiz i Altaba, A. 1997. Cell. 90: 193-6. PMID: 9244291
  11. 刺猬信号通路上的融合连接抑制因子和幼鼠中断因子。  |  Monnier, V., et al. 1998. Curr Biol. 8: 583-6. PMID: 9601642
  12. 刺猬刺激立方体间断物成熟为易变转录激活物。  |  Ohlmeyer, JT. and Kalderon, D. Nature. 396: 749-53. PMID: 9874371

订购信息

产品名称产品编号规格价格数量收藏夹

Su[fu] 抗体 (F-4)

sc-137014
200 µg/ml
RMB2377.00

Su[fu] (F-4): m-IgGκ BP-HRP 套装

sc-521394
200 µg Ab, 40 µg BP
RMB2662.00

Su[fu] (F-4): m-IgG2a BP-HRP 套装

sc-546095
200 µg Ab; 10 µg BP
RMB2662.00

Su[fu] 抗体 (F-4) AC

sc-137014 AC
500 µg/ml, 25% agarose
RMB3129.00

Su[fu] 抗体 (F-4) HRP

sc-137014 HRP
200 µg/ml
RMB2377.00

Su[fu] 抗体 (F-4) FITC

sc-137014 FITC
200 µg/ml
RMB2482.00

Su[fu] 抗体 (F-4) PE

sc-137014 PE
200 µg/ml
RMB2580.00

Su[fu] 抗体 (F-4) Alexa Fluor® 488

sc-137014 AF488
200 µg/ml
RMB2685.00

Su[fu] 抗体 (F-4) Alexa Fluor® 546

sc-137014 AF546
200 µg/ml
RMB2685.00

Su[fu] 抗体 (F-4) Alexa Fluor® 594

sc-137014 AF594
200 µg/ml
RMB2685.00

Su[fu] 抗体 (F-4) Alexa Fluor® 647

sc-137014 AF647
200 µg/ml
RMB2685.00

Su[fu] 抗体 (F-4) Alexa Fluor® 680

sc-137014 AF680
200 µg/ml
RMB2685.00

Su[fu] 抗体 (F-4) Alexa Fluor® 790

sc-137014 AF790
200 µg/ml
RMB2685.00

I need to use an antibody to detect the protein in samples of bovine origin. Do you know if sc-137014: Su(fu) (F-4) mouse monoclonal antibody will work?

Asked by: cjMara
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Great antibody!I bought this antibody few weeks ago, and I had an excellent experience on using it. The antibody is highly specific and works great in Western Blot assay. I would definitely recommend it to whoever works on the Su protein.
Date published: 2021-03-22
Rated 2 out of 5 by from ConfusedUsed at 1:50 to get staining. Labeled the entire cilia in MEFs, contrary to reports in the literature. In human cells, it labeled the cilia tip, basal bodies, and some axome staining. Do not know what to make of this.
Date published: 2020-02-26
Rated 5 out of 5 by from Very good antibody for WBIt works very well (WB). I used it on cerebellar lysates (P20).
Date published: 2019-01-09
Rated 4 out of 5 by from 抗体能够使用!抗体所反映的结果真是可靠,效价能够满足要求,相较于其他品牌有一定程度的优势,未来扩大样本验证这个货号是我的首选。
Date published: 2017-09-21
Rated 5 out of 5 by from !works~works great with 50 ug 3t3 lysate. used at 1:1000 overnight
Date published: 2017-05-10
Rated 5 out of 5 by from Good antibodyThe result of western blot is sharp and single.From ATDC5 cell line
Date published: 2017-03-30
Rated 5 out of 5 by from SUFU is a good antibody in western blotyou can get good western blot data of SUFU expression in human prostate cancer vcap,dilution the SUFU in 1:1000
Date published: 2017-03-14
Rated 5 out of 5 by from Good Western Blot data of Su fu expression in nonGood Western Blot data of Su fu expression in non-transfected and human Su fu transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-06-24
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Su[fu] 抗体 (F-4) is rated 4.5 out of 5 by 8.
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