Date published: 2025-9-7

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SR-2C 抗体 (D-12): sc-17797

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说明书
  • SR-2C 抗体 D-12 是小鼠单克隆 IgG1 κ,SR-2C抗体, 在43篇文献中引用,规格为200 µg/ml
  • 免疫human来源serotonin receptor 2C位于C-terminus 的374-458氨基酸
  • SR-2C 抗体 (D-12) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 serotonin 2C receptor (5-HT2C)
  • 抗SR-2C抗体(D-12)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取SR-2C (D-12): sc-17797免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 SR-2C 抗体 (D-12) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与SR-2C 抗体 (D-12) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

SR-2C抗体(D-12)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的SR-2C蛋白。SR-2C (D-12) 抗体有非结合型和多种结合型可供选择,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。SR-2C蛋白,又称5-羟色胺受体2C,是G蛋白偶联受体家族的一员,在调节5-羟色胺效应方面发挥着关键作用,而5-羟色胺是一种参与多种生理过程的重要神经递质。SR-2C蛋白主要位于中枢神经系统,对于调节情绪、焦虑和食欲至关重要,并且与多种非典型抗精神病药物的作用机制有关。SR-2C蛋白能够激活磷脂酶C并释放细胞内钙储备,对于其功能至关重要,因为SR-2C会影响神经信号通路,从而影响行为和情绪反应。此外,SR-2C蛋白与其他5-羟色胺受体(如SR-2A和SR-2B)的相互作用,在5-羟色胺信号传导和潜在的精神疾病影响这一更广泛的背景下凸显出其重要性,这使得抗SR-2C抗体(D-12)成为研究人员研究这些复杂生物系统的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SR-2C 抗体 (D-12) 参考文献:

  1. 大鼠大脑中血清素(2A)(5HT(2A))受体的细胞定位。  |  Xu, T. and Pandey, SC. 2000. Brain Res Bull. 51: 499-505. PMID: 10758340
  2. 心脏发育需要羟色胺 2B 受体。  |  Nebigil, CG., et al. 2000. Proc Natl Acad Sci U S A. 97: 9508-13. PMID: 10944220
  3. 非典型抗精神病药物对人类 5- 羟色胺 2C受体的反向激动活性。  |  Herrick-Davis, K., et al. 2000. J Pharmacol Exp Ther. 295: 226-32. PMID: 10991983
  4. 5-HT 在调节大脑-垂体-肾上腺轴中的作用:5-HT 对肾上腺皮质细胞的影响。  |  Contesse, V., et al. 2000. Can J Physiol Pharmacol. 78: 967-83. PMID: 11149386
  5. 利用基因敲除小鼠剖析血清素系统在神经精神疾病中的作用。  |  Gingrich, JA. and Hen, R. 2001. Psychopharmacology (Berl). 155: 1-10. PMID: 11374326
  6. 5-HT2C受体激动剂对成瘾性疾病的治疗潜力。  |  Higgins, GA. and Fletcher, PJ. 2015. ACS Chem Neurosci. 6: 1071-88. PMID: 25870913
  7. 血清素 5-HT2A 和 5-HT2C 受体相互作用的生物物理验证。  |  Felsing, DE., et al. 2018. PLoS One. 13: e0203137. PMID: 30157263
  8. 5-羟色胺2C受体功能丧失的人类变异与肥胖和适应不良行为有关。  |  He, Y., et al. 2022. Nat Med. 28: 2537-2546. PMID: 36536256
  9. 海马兴奋-抑制平衡是5-HT2C受体调节抑郁行为的基础。  |  Shi, HJ., et al. 2024. Brain. 147: 3764-3779. PMID: 38701344
  10. 表达5-羟色胺2C受体的神经回路调节小鼠和人类的记忆。  |  Liu, H., et al. 2024. Sci Adv. 10: eadl2675. PMID: 38941473
  11. 豚鼠气管中的收缩羟色胺-2A 受体信号转导:蛋白激酶 C 和细胞外及细胞内钙的重要性,而非磷脂水解的重要性。  |  Watts, SW., et al. 1994. J Pharmacol Exp Ther. 271: 832-44. PMID: 7965803
  12. 血清素通过 5-HT2A 受体诱导早期反应基因前列腺素 G/H 合成酶-2和egr-1的信号通路。  |  Goppelt-Struebe, M. and Stroebel, M. 1998. J Cell Physiol. 175: 341-7. PMID: 9572479

订购信息

产品名称产品编号规格价格数量收藏夹

SR-2C 抗体 (D-12)

sc-17797
200 µg/ml
RMB2377.00

SR-2C (D-12): m-IgG Fc BP-HRP 套装

sc-526571
200 µg Ab; 10 µg BP
RMB2662.00

SR-2C (D-12): m-IgG1 BP-HRP 套装

sc-531944
200 µg Ab; 20 µg BP
RMB2662.00

SR-2C 抗体 (D-12) AC

sc-17797 AC
500 µg/ml, 25% agarose
RMB3129.00

SR-2C 抗体 (D-12) HRP

sc-17797 HRP
200 µg/ml
RMB2377.00

SR-2C 抗体 (D-12) FITC

sc-17797 FITC
200 µg/ml
RMB2482.00

SR-2C 抗体 (D-12) PE

sc-17797 PE
200 µg/ml
RMB2580.00

SR-2C 抗体 (D-12) Alexa Fluor® 488

sc-17797 AF488
200 µg/ml
RMB2685.00

SR-2C 抗体 (D-12) Alexa Fluor® 546

sc-17797 AF546
200 µg/ml
RMB2685.00

SR-2C 抗体 (D-12) Alexa Fluor® 594

sc-17797 AF594
200 µg/ml
RMB2685.00

SR-2C 抗体 (D-12) Alexa Fluor® 647

sc-17797 AF647
200 µg/ml
RMB2685.00

SR-2C 抗体 (D-12) Alexa Fluor® 680

sc-17797 AF680
200 µg/ml
RMB2685.00

SR-2C 抗体 (D-12) Alexa Fluor® 790

sc-17797 AF790
200 µg/ml
RMB2685.00

I am studying this protein in bovine samples. Will this antibody work?

Asked by: Cweed
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 9
Date published: 2017-01-09
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Rated 5 out of 5 by from Works pretty well for WBI tried this antibody in brain tissue extracts, and it works well for WB
Date published: 2018-04-18
Rated 5 out of 5 by from effect was obviouslyThis worked very well for WB with rat brain extracts.
Date published: 2017-05-20
Rated 5 out of 5 by from 试用小样,抗体很好用免疫组化结果很好,细胞形态很清晰,服务态度很好,小样好用已经考虑入正装,好用好用好用好用好用好用好用
Date published: 2017-03-27
Rated 5 out of 5 by from Clear SR-2C detection.This antibody will provide the results you are looking for. Whether it is IHC or WB, you are going to see a strong clear signal. It works in mouse, rat, and human and has been published more than 20 times.
Date published: 2017-01-12
Rated 5 out of 5 by from Wow!! Great ihcIhc staining results far better than polyclonal alternatives; also very nice wb data
Date published: 2017-01-06
Rated 4 out of 5 by from WBWB, IC, proximity ligation assay good signals, mouse; brain homogenate, brain slices, neurons. successfully published.
Date published: 2016-07-22
Rated 5 out of 5 by from Published in IP and WB in hamster CHO cellsPublished in IP and WB in hamster CHO cells. -SCBT Publication Review
Date published: 2015-05-10
Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human placenta tissue. -SCBT QC
Date published: 2015-05-01
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SR-2C 抗体 (D-12) is rated 4.9 out of 5 by 11.
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