Date published: 2025-9-7

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spectrin β II 抗体 (H-5): sc-374125

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说明书
  • spectrin β II抗体(H-5)是小鼠单克隆IgG3 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的spectrin β II的C-terminus附近的氨基酸2229-2261之间
  • 推荐用于 mouse, rat 和 human 来源的spectrin β II WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine and bovine
  • m-IgG3 BP-HRPm-IgGκ BP-HRP是spectrin β II Antibody (H-5) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与spectrin β II Antibody (H-5) 打包提供(请参阅下面的订购信息)。

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    関連項目

    血影蛋白是一种肌动蛋白结合蛋白,是红细胞质膜细胞骨架超结构的主要组成部分。血影蛋白通过形成二聚体、四聚体和更高的聚合物发挥膜组织者和稳定剂的作用。血影蛋白α I和血影蛋白β I存在于红细胞中,而血影蛋白α II(也称为fodrin α)和血影蛋白β II(也称为fodrin β)则存在于其他体细胞中。红细胞中的血影蛋白四聚体作为横向扩散的屏障,但血影蛋白二聚体似乎缺乏这一功能。血影蛋白β II参与分泌,以钙依赖的方式与钙调蛋白相互作用,因此是膜上细胞骨架钙依赖性运动的候选者。人类SPTBN1基因编码非红细胞形式的β-血影蛋白。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    spectrin β II 抗体 (H-5) 参考文献:

    1. 非红细胞β谱蛋白相互作用蛋白及其对谱蛋白四聚化的影响  |  Sevinc, A. and Fung, LW. 2011. Cell Mol Biol Lett. 16: 595-609. PMID: 21866423
    2. 突触核蛋白通过与 SPTBN1 相互作用调节神经元的生长。  |  Lee, HJ., et al. 2012. Biochem Biophys Res Commun. 424: 497-502. PMID: 22771809
    3. SPTBN1 通过 SOCS3 介导的 JAK/STAT3 信号通路阻断作用抑制上皮性卵巢癌的进展。  |  Chen, M., et al. 2020. Aging (Albany NY). 12: 10896-10911. PMID: 32516133
    4. SPTBN1 通过下调 miR-21 抑制乳腺癌的生长和上皮-间质转化。  |  Wu, H., et al. 2021. Eur J Pharmacol. 909: 174401. PMID: 34358482
    5. SPTBN1 的缺失通过 SETD7 介导的 YAP 甲基化抑制肝细胞癌发生和发展过程中的自噬作用  |  Chen, S., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 949-973.e7. PMID: 34737104
    6. β2-spectrin(SPTBN1)作为饮食诱发肝病和预防癌症发展的治疗靶点。  |  Rao, S., et al. 2021. Sci Transl Med. 13: eabk2267. PMID: 34910547
    7. SPTBN1 通过与 PIK3R2 结合,可减轻类风湿性关节炎滑膜细胞的增殖、侵袭、迁移和炎症反应。  |  Dai, LP., et al. 2022. Immun Inflamm Dis. 10: e724. PMID: 36444616
    8. SPTBN1 通过糖酵解重编程以 GPT2 依赖性方式抑制肾透明细胞癌的进展。  |  Wu, J., et al. 2022. J Transl Med. 20: 603. PMID: 36527113
    9. 基于泛癌分析的研究:非红细胞谱蛋白 Beta 1 (SPTBN1) 在人类肾脏透明细胞癌和葡萄膜黑色素瘤中的临床意义。  |  Tang, W., et al. 2023. BMC Cancer. 23: 303. PMID: 37013511
    10. 白细胞介素-27诱导的抗艾滋病毒树突状细胞以独立于 SPTBN1、自噬和 YB-1 的方式抑制病毒进入后的 reveres 转录物。  |  Imamichi, T., et al. 2023. PLoS One. 18: e0287829. PMID: 37910521

    订购信息

    产品名称产品编号规格价格数量收藏夹

    spectrin β II 抗体 (H-5)

    sc-374125
    200 µg/ml
    RMB2377.00

    spectrin β II (H-5): m-IgGκ BP-HRP 套装

    sc-535391
    200 µg Ab; 40 µg BP
    RMB2662.00

    spectrin β II (H-5): m-IgG3 BP-HRP 套装

    sc-550308
    200 µg Ab; 40 µg BP
    RMB2662.00

    spectrin β II (H-5) 中和勝肽

    sc-374125 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-374125 P appropriate for?

    Asked by: cjMara
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 5 out of 5 by from Beautiful IHC of choroid plexus epithelial cells!Wonderful staining of mouse choroid plexus epithelial cells. We take whole mount explants and fix for 10 minutes in 4% PFA, then proceed to immunostaining. 1:200 overnight at 4C in PBS + 0.1% Triton-X.
    Date published: 2024-11-20
    Rated 5 out of 5 by from Produced beautiful immunofluorescence cytoskeletalProduced beautiful immunofluorescence cytoskeletal staining in methanol-fixed HeLa cells. -SCBT QC
    Date published: 2015-03-13
    Rated 5 out of 5 by from Good Western Blot data of spectrin II expressionGood Western Blot data of spectrin II expression in HeLa whole cell lysate. -SCBT QC
    Date published: 2013-12-12
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    spectrin β II 抗体 (H-5) is rated 5.0 out of 5 by 3.
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