Date published: 2026-10-20

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SPARC Antibody (D-2) - Immunohistochemistry - Image 370159
SPARC 抗体 (D-2): sc-398419. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色, 显示肾小管细胞的胞浆染色.
SPARC 抗体 (D-2): sc-398419. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色, 显示肾小管细胞的胞浆染色.

SPARC 抗体 (D-2): sc-398419

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说明书
  • SPARC 抗体 D-2 是小鼠单克隆 IgG2b κ，SPARC抗体, 在6篇文献中引用，规格为200 µg/ml
  • 免疫human物种的SPARC的氨基酸1-90
  • SPARC 抗体 (D-2) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测human 来源的 SPARC
  • 抗SPARC抗体（D-2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是SPARC Antibody (D-2) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与SPARC Antibody (D-2) 打包提供（请参阅下面的订购信息）。
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関連項目

附加SPARC抗体，包括SPARCL1

SPARC抗体（D-2）是一种IgG2b κ小鼠单克隆SPARC抗体（也称为骨连蛋白抗体），可通过WB、IP、IF、IHC(P)和ELISA检测人源的SPARC蛋白。SPARC抗体（D-2）既有非偶联形式的抗SPARC抗体，也有多种偶联形式的抗SPARC抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。SPARC（即富含硫氨酸的酸性分泌蛋白）是一种富含甘氨酸的磷酸化酸性糖蛋白，由内皮细胞分泌，在小鼠胚胎的腹壁内胚层中大量存在，并在人类胎盘中也有存在。它与骨连结蛋白完全相同，骨连结蛋白是一种对骨钙化非常重要的蛋白，在物种之间高度保守。SPARC可以在受到某些类型的损伤时被内皮细胞选择性地表达，在体外诱导内皮细胞黏附变圆。它通过F-Actin依赖的细胞形态变化来调节内皮屏障功能，与细胞间缝隙的出现同时发生，为大分子的跨膜转运提供了一条细胞间通道。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SPARC 抗体 (D-2) 参考文献:

  1. SPARC是一种基质蛋白，在细胞分化和组织损伤反应中发挥作用。  |  Bradshaw, AD. and Sage, EH. 2001. J Clin Invest. 107: 1049-54. PMID: 11342565
  2. SPARC改善卵巢癌相关的炎症。  |  Said, NA., et al. 2008. Neoplasia. 10: 1092-104. PMID: 18813349
  3. SPARC在肿瘤进展中调节基质重塑。  |  Chlenski, A. and Cohn, SL. 2010. Semin Cell Dev Biol. 21: 55-65. PMID: 19958839
  4. 海马SPARC可调节抑郁相关行为。  |  Campolongo, M., et al. 2012. Genes Brain Behav. 11: 966-76. PMID: 22950524
  5. SPARC通过Rac1控制黑色素瘤细胞的塑性。  |  Salvatierra, E., et al. 2015. PLoS One. 10: e0134714. PMID: 26248315
  6. SPARC可保持昆虫卵巢中卵泡上皮完整。  |  Irles, P., et al. 2017. Dev Biol. 422: 105-114. PMID: 28089848
  7. SPARC可抑制卵巢癌的代谢可塑性。  |  Naczki, C., et al. 2018. Cancers (Basel). 10: PMID: 30332737
  8. 动脉瘤性蛛网膜下腔出血后延迟性脑缺血的血浆SPARC升高。  |  Nakajima, H., et al. 2023. Neurotherapeutics. 20: 779-788. PMID: 36781745
  9. ROS通过胞吞作用破坏肿瘤血管的正常化。  |  Zhao, Y., et al. 2023. Cancer Cell Int. 23: 152. PMID: 37528424
  10. 下调SPARC表达可增强BeWo绒毛膜癌细胞的融合。  |  Togo, A., et al. 2024. Reprod Sci. 31: 2342-2353. PMID: 38728000

订购信息

产品名称产品编号规格价格数量收藏夹

SPARC 抗体 (D-2)

sc-398419
200 µg/ml
CNY2422.00

SPARC (D-2): m-IgGκ BP-HRP 套装

sc-524330
200 µg Ab, 40 µg BP
CNY2715.00

SPARC (D-2): m-IgG2b BP-HRP 套装

sc-549160
200 µg Ab; 10 µg BP
CNY2715.00

SPARC 抗体 (D-2) AC

sc-398419 AC
500 µg/ml, 25% agarose
CNY3189.00

SPARC 抗体 (D-2) HRP

sc-398419 HRP
200 µg/ml
CNY2422.00

SPARC 抗体 (D-2) FITC

sc-398419 FITC
200 µg/ml
CNY2527.00

SPARC 抗体 (D-2) PE

sc-398419 PE
200 µg/ml
CNY2625.00

SPARC 抗体 (D-2) Alexa Fluor® 488

sc-398419 AF488
200 µg/ml
CNY2738.00

SPARC 抗体 (D-2) Alexa Fluor® 546

sc-398419 AF546
200 µg/ml
CNY2738.00

SPARC 抗体 (D-2) Alexa Fluor® 594

sc-398419 AF594
200 µg/ml
CNY2738.00

SPARC 抗体 (D-2) Alexa Fluor® 647

sc-398419 AF647
200 µg/ml
CNY2738.00

SPARC 抗体 (D-2) Alexa Fluor® 680

sc-398419 AF680
200 µg/ml
CNY2738.00

SPARC 抗体 (D-2) Alexa Fluor® 790

sc-398419 AF790
200 µg/ml
CNY2738.00

FREE 10 µg sample of SPARC (D-2): sc-398419. Can I have this antibody for free trial?

Asked by: morncafe
For a limited time, we are offering a free 10 µg sample of this antibody. Please contact our Technical Service Department if you would like to test the antibody before placing your order. Please call us toll-free at (800) 457-3801 option 2, e-mail <[email protected]>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-11-22

Can SPARC (D-2): sc-398419 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jenniferc
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, SPARC (D-2): sc-398419 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by morncafe from Working perfectThis antibody stained the target perfectly for the immunofluorescent staining of cells.
Date published: 2017-12-13
Rated 5 out of 5 by caveman from excellenttested on rat tissue samples in western blot and worked perfectly.
Date published: 2017-12-13
Rated 5 out of 5 by siqiwang from Successful application of this antibody in IFSuccessful application of this antibody in IF, using human tissues.
Date published: 2017-09-17
Rated 5 out of 5 by feixia from Very easy to useThe first time I used this antibody it gave excellent WB signals. No problem, will continue to use.
Date published: 2017-05-22
Rated 5 out of 5 by hudbt17089 from Positive result in western blot analysisPositive result in western blot analysis of sparc expression in human cartilage tissue extract. -ZGL
Date published: 2017-04-17
Rated 5 out of 5 by wangmingjix 5 from Powerful antibodiesPowerful antibodies work by the bank with pancreatic cancer cell line SPARC WB and ELISA detection
Date published: 2017-02-11
Rated 5 out of 5 by zhuergou01 from specific bandsThe specific bands were detected by Western blot and 1:500 in human tissues.
Date published: 2017-02-09
Rated 5 out of 5 by TinTin from Excellent choice for SPARC detection!This is a strong and reliable antibody for both IF and WB. Can't go wrong: nice and clean!
Date published: 2017-01-18
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SPARC 抗体 (D-2) is rated 4.8 out of 5 by 12.
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