Date published: 2025-9-7
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Sox-17 Antibody (3.5CH) - Immunohistochemistry - Image 291097
Sox-17 抗体 (3. 5CH): sc-130295. 免疫过氧化物酶染色 E11. 5 小鼠胚胎, 低倍镜 (A) 和高倍镜 (B, C) 显示内皮细胞中 Sox 17 的表达. 由 Bioclinova 的 Peter Dias 博士友情提供.
Sox-17 抗体 (3. 5CH): sc-130295. 免疫过氧化物酶染色 E11. 5 小鼠胚胎, 低倍镜 (A) 和高倍镜 (B, C) 显示内皮细胞中 Sox 17 的表达. 由 Bioclinova 的 Peter Dias 博士友情提供.

Sox-17 抗体 (3.5CH): sc-130295

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说明书
  • Sox-17 抗体 3.5CH 是小鼠单克隆 IgG1 κ，Sox-17抗体, 在15篇文献中引用，规格为200 µg/ml
  • 免疫mouse物种的重组Sox-17
  • Sox-17 抗体 (3.5CH) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测mouse 来源的 Sox-17
  • 抗Sox-17抗体（3.5CH）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Sox-17 (3.5CH): sc-130295的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Sox-17 抗体 (3.5CH) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Sox-17 抗体 (3.5CH) 组合成套装提供。 (请参阅下面的订购信息)。

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相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Sox 抗体 包括 Sox-10, Sox-13, Sox-15, Sox-17, Sox-18, Sox-2, Sox-21, Sox-22, Sox-3和Sox-30

Sox-17抗体（3.5CH）是一种IgG1κ小鼠单克隆Sox-17抗体（也称为SOX17抗体或SRY相关HMG-box转录因子17抗体），可通过WB、IP、IF、IHC（P）和ELISA检测小鼠来源的Sox-17蛋白。Sox-17抗体（3.5CH）有非偶联抗Sox-17抗体形式和多种偶联形式的抗Sox-17抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Sox基因是一个与哺乳动物性别决定基因SRY相关的基因家族。这些基因同样含有编码HMG-box结构域的序列，该结构域负责序列特异性DNA结合活性。Sox基因编码推定的转录调节因子，参与发育过程中细胞命运的决定和各种发育过程的控制。高度复杂的Sox基因组簇至少包含40个不同的位点，这些位点在各种动物谱系中迅速分化。目前，已鉴定出30个Sox基因。该家族的成员在进化过程中被证明是保守的，并在动物发育过程中发挥关键作用。一些与人类疾病有关，包括性反转。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Sox-17 抗体 (3.5CH) 参考文献:

  1. 鉴定新型 Sry 相关基因及其生殖细胞特异性表达。  |  Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
  2. Sox 因子在神经决定过程中的作用：进化中的保守信号传递？  |  Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
  3. SOX17是人类原始生殖细胞命运的关键决定因素。  |  Irie, N., et al. 2015. Cell. 160: 253-68. PMID: 25543152
  4. Sox17缺乏通过HGF/c-Met信号传导促进肺动脉高血压。  |  Park, CS., et al. 2022. Circ Res. 131: 792-806. PMID: 36205124
  5. SOX17缺陷介导肺动脉高压：在性别、代谢和遗传学的交叉路口。  |  Sangam, S., et al. 2023. Am J Respir Crit Care Med. 207: 1055-1069. PMID: 36913491
  6. SOX17通过外泌体介导的自体分泌方式维持肺动脉高血压内皮功能的关键因素。  |  Zou, X., et al. 2023. Adv Sci (Weinh). 10: e2206139. PMID: 36919784
  7. SOX17 增强子变异破坏转录因子结合，增强子失活导致肺动脉高压  |  Walters, R., et al. 2023. Circulation. 147: 1606-1621. PMID: 37066790
  8. E2F1介导SOX17缺陷诱导的肺动脉高压。  |  Yi, D., et al. 2023. Hypertension. 80: 2357-2371. PMID: 37737027
  9. SOX17使早期结直肠腺瘤和癌症免疫逃逸成为可能。  |  Goto, N., et al. 2024. Nature. 627: 636-645. PMID: 38418875
  10. HMG 盒超家族的起源和多样性。  |  Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
  11. 神经胶质细胞中的新型转录调节器 Sox10  |  Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
  12. 人类 SOX14 基因的特征和图谱。  |  Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951

订购信息

产品名称产品编号规格价格数量收藏夹

Sox-17 抗体 (3.5CH)

sc-130295
200 µg/ml
RMB2377.00

Sox-17 (3.5CH): m-IgG Fc BP-HRP 套装

sc-527079
200 µg Ab; 10 µg BP
RMB2662.00

Sox-17 (3.5CH): m-IgG1 BP-HRP 套装

sc-532452
200 µg Ab; 20 µg BP
RMB2662.00

Sox-17 抗体 (3.5CH) AC

sc-130295 AC
500 µg/ml, 25% agarose
RMB3129.00

Sox-17 抗体 (3.5CH) HRP

sc-130295 HRP
200 µg/ml
RMB2377.00

Sox-17 抗体 (3.5CH) FITC

sc-130295 FITC
200 µg/ml
RMB2482.00

Sox-17 抗体 (3.5CH) PE

sc-130295 PE
200 µg/ml
RMB2580.00

Sox-17 抗体 (3.5CH) Alexa Fluor® 488

sc-130295 AF488
200 µg/ml
RMB2685.00

Sox-17 抗体 (3.5CH) Alexa Fluor® 546

sc-130295 AF546
200 µg/ml
RMB2685.00

Sox-17 抗体 (3.5CH) Alexa Fluor® 594

sc-130295 AF594
200 µg/ml
RMB2685.00

Sox-17 抗体 (3.5CH) Alexa Fluor® 647

sc-130295 AF647
200 µg/ml
RMB2685.00

Sox-17 抗体 (3.5CH) Alexa Fluor® 680

sc-130295 AF680
200 µg/ml
RMB2685.00

Sox-17 抗体 (3.5CH) Alexa Fluor® 790

sc-130295 AF790
200 µg/ml
RMB2685.00

I want to use Sox-17 (3.5CH): sc-130295 antibody for ChIP Seq. What is the epitope region that the antibody is raised against?

Asked by: Sweta
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-06-09

I am using Sox-17 (3.5CH): sc-130295 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Randy McDonald
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 3 out of 5 by from Some difficulty identifying endoderm cellsI used this antibody to attempt to identify endoderm cells after differentiating an hiPS cell line. The antibody seems to stain nuclei successfully in the cells I tested, though it was difficult to differentiate iPS cells from endoderm cells using this antibody alone. Thus, anyone attempting to use this antibody to identify endoderm cells may want to use it in conjunction with another antibody.
Date published: 2018-02-28
Rated 5 out of 5 by from IHCThis antibody works great for IHC, I get strong signal for IHC at the correct position, it is very easy to get sucessful result.
Date published: 2017-09-02
Rated 5 out of 5 by from WBI suggest use this antibody for WB detect Sox-17 .We have tried different conditions ,1:500 dilution ,4℃ overnight incubation is the optimized condition.
Date published: 2017-08-26
Rated 5 out of 5 by from Ottimo anticorpoNel mio laboratorio abbiamo testato l'anticorpo Sox-17 (3.5CH): sc-130295 su cellule staminali mesenchimali umane adulte sia per Western blotting (1:400 dil ) che per immunofluorescenza (1:200 dil). In entrami i casi abbiamo ottenuto un bel risultato, senza aspecifico. A mio parere è un ottimo prodotto.
Date published: 2017-03-15
Rated 5 out of 5 by from Excellent!This antibody is great in Western blot analysis of Sox-17 expression in MDCK cell lysate.
Date published: 2017-01-23
Rated 5 out of 5 by from The Sox on mice liver - 17 WB and IP results signiIn antibody test on mice liver Sox - 17 WB and IP results significantly
Date published: 2017-01-12
Rated 3 out of 5 by from Worked well for WB with mouse transfected lysatesWorked well for WB with mouse transfected lysates. -SCBT QC
Date published: 2015-01-24
Rated 4 out of 5 by from Good WB with single strong band in MDCKGood WB with single strong band in MDCK. -SCBT QC
Date published: 2015-01-07
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Sox-17 抗体 (3.5CH) is rated 4.2 out of 5 by 9.
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