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Superoxide Dismutase 1/SOD1 Antibody (B-1) - Western Blotting - Image 128571
SOD-1 抗体 (B-1): sc-271014. 非转染: sc-117752 (A) 和小鼠 SOD-1 转染: sc-123711 (B) 293T 全细胞裂解液中 SOD-1 表达的 Western 印迹分析.
Superoxide Dismutase 1/SOD1 Antibody (B-1) - Western Blotting - Image 128571
SOD-1 抗体 (B-1): sc-271014. 非转染: sc-117752 (A) 和小鼠 SOD-1 转染: sc-123711 (B) 293T 全细胞裂解液中 SOD-1 表达的 Western 印迹分析.
SOD-1 抗体 (B-1): sc-271014. 非转染: sc-117752 (A) 和小鼠 SOD-1 转染: sc-123711 (B) 293T 全细胞裂解液中 SOD-1 表达的 Western 印迹分析.

Superoxide Dismutase 1/SOD1 抗体 (B-1): sc-271014

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寫評論提問

说明书
  • Superoxide Dismutase 1/SOD1 抗体 B-1 是小鼠单克隆 IgM, 在65篇文献中引用，提供 200 µg/ml
  • 与氨基酸序列C-terminus（h）对应的多肽序列（SOD-1的human起源）
  • 推荐用于 mouse, rat 和 human 来源的SOD-1 WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： 和 equine, bovine and porcine
  • 看 Superoxide Dismutase 1/SOD1 (G-11): sc-17767，可查看有标记的 Superoxide Dismutase 1/SOD1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取Superoxide Dismutase 1/SOD1 (B-1): sc-271014的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成Superoxide Dismutase 1/SOD1 抗体 (B-1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 SOD 抗体包括 SOD-1, SOD-2 和 SOD-3

Superoxide Dismutase 1/SOD1 抗体（B-1）是一种 IgM 小鼠单克隆 SOD-1 抗体（也称为 SOD-1 抗体），可通过 WB、IP、IF 和 ELISA 检测小鼠、大鼠和人类的 SOD-1。Superoxide Dismutase 1/SOD1 抗体（B-1）为非偶联的抗 SOD-1 抗体形式。Cu-Zn 超氧化物歧化酶-1（SOD-1）是一种特征明确的氧自由基胞质清除剂，需要铜和锌结合以增强其酶活性。在酶促反应中，SOD-1 促进氧自由基歧化为过氧化氢，并催化促氧化反应，包括过氧化物酶活性和羟基自由基生成活性。SOD-1 在体细胞中普遍表达，并以同源二聚体的形式发挥作用。编码 SOD-1 的基因缺陷与神经系统疾病的进展有关，包括肌萎缩侧索硬化症（ALS，一种以脊髓运动神经元丧失为特征的神经退行性疾病）、唐氏综合征和阿尔茨海默病。在家族性 ALS 中，SOD-1 的几种突变占主导地位，导致锌结合丧失、SOD-1 清除活性丧失，并与神经毒性和运动神经元死亡增加相关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Superoxide Dismutase 1/SOD1 抗体 (B-1) 参考文献:

  1. 通过将 Cu/Zn SOD-1 基因转入脑血管防止蛛网膜下腔出血急性期脑血流自动调节功能受损。  |  Shin, HK., et al. 2003. J Cereb Blood Flow Metab. 23: 111-20. PMID: 12500096
  2. 与玉米叶绿体有关的基因定义的超氧化物歧化酶（SOD-1）的纯化和部分特征。  |  Baum, JA., et al. 1983. Plant Physiol. 73: 31-5. PMID: 16663180
  3. SOD同工型在自由饮食或饮食限制条件下对寿命没有影响，但SOD-1的突变失活会减少低温下的寿命延长。  |  Yen, K., et al. 2009. Mech Ageing Dev. 130: 173-8. PMID: 19059428
  4. SOD-1突变引起的散发性和家族性肌萎缩侧索硬化症的运动神经元损伤和轴突再生差异：神经生理学的启示。  |  Bocci, T., et al. 2011. Int J Mol Sci. 12: 9203-15. PMID: 22272128
  5. 家族性肌萎缩侧索硬化症中SOD-1（Gly 108 Val）的新突变。  |  Orrell, RW., et al. 1997. Eur J Neurol. 4: 48-51. PMID: 24283821
  6. 人类 21 号染色体上编码铜/锌超氧化物歧化酶的染色体位点的结构和解剖。  |  Levanon, D., et al. 1985. EMBO J. 4: 77-84. PMID: 3160582
  7. 小鼠铜锌超氧化物歧化酶的 cDNA 和推导氨基酸序列。  |  Bewley, GC. 1988. Nucleic Acids Res. 16: 2728. PMID: 3362683
  8. 新型 SOD 突变体与渐冻症  |  Orrell, R., et al. 1995. Nature. 374: 504-5. PMID: 7700376
  9. ALS, SOD 和过氧化亚硝酸盐。  |  Beckman, JS., et al. 1993. Nature. 364: 584. PMID: 8350919
  10. SOD-1 全部五个外显子的突变都可能导致 ALS。  |  Shaw, CE., et al. 1998. Ann Neurol. 43: 390-4. PMID: 9506558
  11. 重新研究家族性肌萎缩性脊髓侧索硬化症相关铜, 锌超氧化物歧化酶突变体与 H2O2 反应形成羟自由基加合物的机制。  |  Singh, RJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 6675-80. PMID: 9618471
  12. 与 ALS 相关的 SOD1 突变体的聚集和运动神经元毒性独立于野生型 SOD1。  |  Bruijn, LI., et al. 1998. Science. 281: 1851-4. PMID: 9743498

订购信息

产品名称产品编号规格价格数量收藏夹

Superoxide Dismutase 1/SOD1 抗体 (B-1)

sc-271014
200 µg/ml
RMB2377.00

Superoxide Dismutase 1/SOD1 (B-1) 中和勝肽

sc-271014 P
100 µg/0.5 ml
RMB511.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with SOD-1 (B-1): sc-271014?

Asked by: cjMara
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 15
Date published: 2017-01-22

Is this sc-271014 available directly conjugated to HRP or fluorescent dyes?

Asked by: cjMara
Thank you for your question. All requests for directly conjugated versions of this antibody should be directed to our Special Orders team at [email protected] Alternatively, consider using SOD-1 Antibody (G-11): sc-17767, which is available conjugated to agarose, HRP, FITC, PE, and more. (https://www.scbt.com/scbt/product/sod-1-antibody-g-11)
Answered by: Technical Support 8
Date published: 2017-01-16
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Rated 5 out of 5 by from Good resultsGood antibody for WB. We used intestinal lysate. Dilution 1:1000
Date published: 2021-01-18
Rated 2 out of 5 by from Faint signal for WBI tested SOD-1 in cerebral cortex lysates of CDKL5 WT and KO mice (40ug). I used a 1:500 dilution and I obtained a faint signal.
Date published: 2020-06-08
Rated 5 out of 5 by from Excellent for western blotting applicationWestern Blotting of HepG2 cell lysate Dilution 1:1000 Specific and strong signal at the expected molecular weight
Date published: 2020-03-02
Rated 4 out of 5 by from Buena señal. Poca suciedad.Probado en células AR42J. Va bastante bien. Buena señal.
Date published: 2019-05-09
Rated 5 out of 5 by from SOD-1 Western blotWestern blot of mouse primary cerebellar neurons conjugated with SOD-1 (1:1000). Very strong expression, little background.
Date published: 2018-03-09
Rated 5 out of 5 by from Good for SOD-1Well-published antibody recommended for detection in multiple species: mouse, rat, human, equine, bovine, and porcine. Good Western blot data obtained.
Date published: 2017-01-23
Rated 5 out of 5 by from Strong western dataFor most applications the SOD-1(G-11) monoclonal antibody clone is a much better product; also available from scbt
Date published: 2017-01-15
Rated 5 out of 5 by from Published data for WB in mouse germ cellsPublished data for WB in mouse germ cells from the mouse testis. -SCBT Publication Review
Date published: 2015-05-16
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Superoxide Dismutase 1/SOD1 抗体 (B-1) is rated 4.7 out of 5 by 13.
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