Date published: 2025-9-8
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SOAT1 Antibody (D-1) - Western Blotting - Image 56378
SOAT1 抗体 (D-1): sc-137013. 未转染 293T: sc-117752 (A), 转染人 SOAT1 的 293T: sc-171897 (B) 和 THP-1 (C) 全细胞裂解液中 SOAT1 表达的 Western 印迹分析.
SOAT1 抗体 (D-1): sc-137013. 未转染 293T: sc-117752 (A), 转染人 SOAT1 的 293T: sc-171897 (B) 和 THP-1 (C) 全细胞裂解液中 SOAT1 表达的 Western 印迹分析.

SOAT1 抗体 (D-1): sc-137013

3.3(4)
寫評論提問

说明书
  • SOAT1 抗体 D-1 是小鼠单克隆 IgG1 (kappa轻链)，SOAT1抗体，规格为200 µg/ml
  • 免疫human物种的SOAT1的氨基酸1-125
  • SOAT1 抗体 (D-1) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测human 来源的 SOAT1
  • 抗SOAT1抗体（D-1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取SOAT1 (D-1): sc-137013的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG1 BP-HRP 是 SOAT1 抗体 (D-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与SOAT1 抗体 (D-1) 组合成套装提供。 (请参阅下面的订购信息)。

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    相关产品
    描述
    基因信息
    蛋白序列
    说明书与实验方案
    研究信息

    関連項目

    额外SOAT抗体，包括SOAT2

    SOAT1抗体（D-1）是一种IgG1 κ小鼠单克隆SOAT1抗体，可通过WB、IP、IF、IHC(P)和ELISA方法检测人源的SOAT1蛋白。SOAT1抗体（D-1）既可以是非偶联的抗SOAT1抗体形式，也可以是多种偶联形式的抗SOAT1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。SOAT1（固醇O-酰基转移酶-1），也称为ACAT1，是一种同源四聚体酶，可催化胆固醇和长链脂肪酸酰基辅酶A（acyl-CoA）形成胆固醇酯。编码人SOAT1的基因定位于1号染色体，并表达为定位于包括肝脏、肾脏、肾上腺和巨噬细胞在内的多种组织内质网（ER）的蛋白质。SOAT1参与细胞胆固醇稳态以及泡沫细胞形成和随后的动脉粥样硬化进展。已经开发了多种SOAT抑制剂用于治疗动脉粥样硬化。SOAT2（固醇O-酰基转移酶-2），也称为ACAT2（酰基辅酶A：胆固醇酰基转移酶-2），参与脂蛋白组装，催化哺乳动物细胞中的胆固醇酯化。SOAT2是一种整合膜蛋白，定位于人肠细胞的内质网。SOAT2缺乏会导致严重智力迟钝和肌张力低下。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    SOAT1 抗体 (D-1) 参考文献:

    1. 抑制 SOAT1 可通过阻断 SREBP-1 介导的脂肪生成抑制胶质母细胞瘤的生长  |  Geng, F., et al. 2016. Clin Cancer Res. 22: 5337-5348. PMID: 27281560
    2. SOAT1甲基化与冠心病有关。  |  Abuzhalihan, J., et al. 2019. Lipids Health Dis. 18: 192. PMID: 31684966
    3. Circ-Tulp4通过调节soat1的表达促进β-细胞对脂肪毒性的适应。  |  Wu, L., et al. 2020. J Mol Endocrinol. 65: 149-161. PMID: 33064661
    4. 敲除固醇 O-酰基转移酶 1（SOAT1）可抑制 SCD1 介导的前列腺癌脂肪生成和癌变过程。  |  Liu, Y., et al. 2021. Prostaglandins Other Lipid Mediat. 153: 106537. PMID: 33454379
    5. 在 SOAT1 靶向治疗结肠癌的过程中，胆固醇激活了 Wnt/PCP-YAP 信号。  |  Xu, H., et al. 2021. Cell Death Discov. 7: 38. PMID: 33637695
    6. SOAT1基因变异和蛋白表达对HBV相关性肝癌的影响。  |  Chen, Y., et al. 2021. BMC Cancer. 21: 615. PMID: 34039309
    7. 同时靶向 SOAT1 和 CPT1A 可通过破坏脂质稳态改善肝细胞癌。  |  Ren, M., et al. 2021. Cell Death Discov. 7: 125. PMID: 34052835
    8. SOAT1通过脂质合成促进胃癌淋巴结转移。  |  Zhu, T., et al. 2021. Front Pharmacol. 12: 769647. PMID: 34790132
    9. piRNA-6426增加DNMT3B介导的SOAT1甲基化并改善心力衰竭。  |  Zhong, N., et al. 2022. Aging (Albany NY). 14: 2678-2694. PMID: 35354120
    10. ACAT1/SOAT1阻断通过调节小胶质细胞中Toll样受体4的命运抑制LPS介导的神经炎症  |  Li, H., et al. 2023. Int J Mol Sci. 24: PMID: 36982689

    订购信息

    产品名称产品编号规格价格数量收藏夹

    SOAT1 抗体 (D-1)

    sc-137013
    200 µg/ml
    		RMB2377.00

    SOAT1 (D-1): m-IgG1 BP-HRP 套装

    sc-531670
    200 µg Ab; 20 µg BP
    		RMB2662.00

    SOAT1 抗体 (D-1) AC

    sc-137013 AC
    500 µg/ml, 25% agarose
    		RMB3129.00

    SOAT1 抗体 (D-1) HRP

    sc-137013 HRP
    200 µg/ml
    		RMB2377.00

    SOAT1 抗体 (D-1) FITC

    sc-137013 FITC
    200 µg/ml
    		RMB2482.00

    SOAT1 抗体 (D-1) PE

    sc-137013 PE
    200 µg/ml
    		RMB2580.00

    SOAT1 抗体 (D-1) Alexa Fluor® 488

    sc-137013 AF488
    200 µg/ml
    		RMB2685.00

    SOAT1 抗体 (D-1) Alexa Fluor® 546

    sc-137013 AF546
    200 µg/ml
    		RMB2685.00

    SOAT1 抗体 (D-1) Alexa Fluor® 594

    sc-137013 AF594
    200 µg/ml
    		RMB2685.00

    SOAT1 抗体 (D-1) Alexa Fluor® 647

    sc-137013 AF647
    200 µg/ml
    		RMB2685.00

    SOAT1 抗体 (D-1) Alexa Fluor® 680

    sc-137013 AF680
    200 µg/ml
    		RMB2685.00

    SOAT1 抗体 (D-1) Alexa Fluor® 790

    sc-137013 AF790
    200 µg/ml
    		RMB2685.00

    I would like to know against which specific epitope of SOAT-1 the antibody Anti-SOAT-1 (sc-137013) is directed, where exactly it is located in the base pair sequence and whether the epitope is located at the N- or C-terminus of SOAT-1.

    Asked by: Baylies
    Thank you for your question. SOAT1 Antibody (D-1): sc-137013 was raised against amino acids 1-125 of SOAT1 of human origin. The exact epitope was not mapped.
    Answered by: Tech Support Europe
    Date published: 2024-03-18

    Does this antibody work for cells or tissues derived from mouse or rat

    Asked by: wendy771
    Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
    Answered by: Technical Service
    Date published: 2022-01-12

    I am using SOAT1 (D-1): sc-137013 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

    Asked by: TinTin
    We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-02-24
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    Rated 2 out of 5 by from AverageGave multi-bands on western blot!! with poor signal
    Date published: 2018-02-07
    Rated 1 out of 5 by from not goodI got very very weak band and mutiband on western blot
    Date published: 2017-07-21
    Rated 5 out of 5 by from Beautiful immunoperoxidase cytoplasmic stainingBeautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
    Date published: 2015-05-09
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    SOAT1 抗体 (D-1) is rated 3.3 out of 5 by 4.
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