Date published: 2025-9-7

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SIRT6 抗体 (2G1H1): sc-517196

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说明书
  • SIRT6 抗体 2G1H1 是小鼠单克隆 IgG1 κ,SIRT6抗体, 在16篇文献中引用,规格为50 µg/0.5 ml
  • 针对与human的SIRT6的氨基酸141-250对应的重组蛋白的部分区域
  • 推荐用于 human 来源的SIRT6 WB, IP, IF 和 ELISA检测
  • 关于如何获取SIRT6 (2G1H1): sc-517196免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成SIRT6 抗体 (2G1H1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

SIRT6抗体(2G1H1)是一种鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测人源SIRT6蛋白。抗SIRT6抗体(2G1H1)以非结合形式提供。SIRT6,也称为SIR2L6,是sirtuin家族的重要成员,由NAD+-依赖性脱乙酰酶组成,在细胞调节中起着重要作用。这种355个氨基酸的蛋白质主要定位于细胞核,作为组蛋白H3赖氨酸9(H3K9)的脱乙酰酶,调节端粒染色质结构,促进DNA修复过程和端粒维持。SIRT6通过调节细胞衰老和寿命来维持基因组稳定性。SIRT6以辅因子的形式结合锌,并通过可变剪接形成四种同工型,从而影响细胞内的功能多样性和调节机制。SIRT6与参与DNA修复和染色质重塑的多种蛋白相互作用,对细胞健康和疾病预防具有重要意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SIRT6 抗体 (2G1H1) 参考文献:

  1. 原核生物和真核生物 Sir2 样蛋白的系统发育分类。  |  Frye, RA. 2000. Biochem Biophys Res Commun. 273: 793-8. PMID: 10873683
  2. 小鼠 Sir2 同源物 SIRT6 是一种核 ADP 核糖基转移酶。  |  Liszt, G., et al. 2005. J Biol Chem. 280: 21313-20. PMID: 15795229
  3. 人类 SIRT 蛋白的进化保守和非保守细胞定域及功能。  |  Michishita, E., et al. 2005. Mol Biol Cell. 16: 4623-35. PMID: 16079181
  4. 人类 Sirtuin 6 基因的染色体组织和荧光原位杂交。  |  Mahlknecht, U., et al. 2006. Int J Oncol. 28: 447-56. PMID: 16391800
  5. 没有它,我们肯定活不下去:SIRT6  |  Rodgers, JT. and Puigserver, P. 2006. Cell Metab. 3: 77-8. PMID: 16459306
  6. SIRT6 在 DNA 修复, 新陈代谢和衰老中的作用。  |  Lombard, DB., et al. 2008. J Intern Med. 263: 128-41. PMID: 18226091
  7. 营养供应对 SIRT6 蛋白水平的调节。  |  Kanfi, Y., et al. 2008. FEBS Lett. 582: 543-8. PMID: 18242175
  8. SIRT6 是一种组蛋白 H3 赖氨酸 9 去乙酰化酶,可调节端粒染色质。  |  Michishita, E., et al. 2008. Nature. 452: 492-6. PMID: 18337721
  9. 没有 SIRT6。  |  Lall, S. 2008. Nat Struct Mol Biol. 15: 336. PMID: 18388907
  10. SIRT6通过慢性肾病中的Runx2保护血管平滑肌细胞免受成骨转分化。  |  Li, W., et al. 2022. J Clin Invest. 132: PMID: 34793336
  11. Sirt6 可减轻软骨细胞的衰老和骨关节炎的发展。  |  Ji, ML., et al. 2022. Nat Commun. 13: 7658. PMID: 36496445
  12. SIRT6调节的巨噬细胞吞噬作用通过表观遗传学控制糖尿病性牙周炎的炎症消退。  |  Li, B., et al. 2023. Theranostics. 13: 231-249. PMID: 36593966

订购信息

产品名称产品编号规格价格数量收藏夹

SIRT6 抗体 (2G1H1)

sc-517196
50 µg/0.5 ml
RMB2377.00

I am using SIRT6 (2G1H1): sc-517196 for immunofluorescence, what dilution of this antibody should I use?

Asked by: cjMara
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from Good antibodyWe tested the antibody on MCF7 cell lysates, it works very well on WB, we got a few extra bands of lower weight
Date published: 2022-05-19
Rated 5 out of 5 by from This antibody can detect Sirt6 in HeLa cells by WBWe acquired this antibody approximately 7 months ago and stored it in 4C. We recently performed a western blot with whole cell lysates of HeLa cells using a 1 to 1000 dilution. We can detect Sirt6 by western blot with a 1 minute exposure. It works.
Date published: 2018-06-21
Rated 5 out of 5 by from Worked well in western blotUsed 1:500 dilution Saw clear double band in MCF7 cells around 36 and 39kd
Date published: 2018-03-02
Rated 5 out of 5 by from WB,IP验效果均不错主要用于IP实验,0.5ug蛋白使用10ul或者5ul抗体,均有不错的效果 WB 1/1000同样显出特异性条带,无非特异性条带干扰,效果不错
Date published: 2017-12-13
Rated 5 out of 5 by from good antibodyit worked well at 1:400 in WB. It gave a clear band.
Date published: 2017-12-05
Rated 4 out of 5 by from Strong WB dataI used this antiboy in WB in my colon cancer cells and got very good results.
Date published: 2017-08-25
Rated 5 out of 5 by from it works wellthe binding is clean and clear for western blot. but there is a little non-soecific binding
Date published: 2017-08-25
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SIRT6 抗体 (2G1H1) is rated 4.7 out of 5 by 7.
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