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SESN3 Antibody (2C9) - Western Blotting - Image 352231
SESN3 抗体 (2C9): sc-517092. Western 印迹分析人胰腺组织提取物中 SESN3 的表达.
SESN3 Antibody (2C9) - Western Blotting - Image 352231
SESN3 抗体 (2C9): sc-517092. Western 印迹分析人胰腺组织提取物中 SESN3 的表达.
SESN3 Antibody (2C9) - Western Blotting - Image 350338
SESN3 抗体 (2C9): sc-517092. 人重组 SESN3 融合蛋白的 Western 印迹分析.
SESN3 抗体 (2C9): sc-517092. Western 印迹分析人胰腺组织提取物中 SESN3 的表达.

SESN3 抗体 (2C9): sc-517092

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说明书
  • SESN3抗体(2C9)是小鼠单克隆IgG1 (kappa轻链)，规格为100 µg/ml
  • 与氨基酸212-321结合，代表human起源的部分长度SESN3
  • 推荐用于 human 来源的SESN3 WB, IP 和 ELISA检测
  • 关于如何获取SESN3 (2C9): sc-517092的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是SESN3 Antibody (2C9) for WB applications. 的首选辅助检测试剂，这些试剂现与SESN3 Antibody (2C9) 打包提供（请参阅下面的订购信息）。

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    相关产品
    描述
    基因信息
    说明书与实验方案
    研究信息

    関連項目

    SESN3抗体（2C9）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测人类SESN3。抗SESN3抗体（2C9）以非结合形式提供。SESN3，也称为sestrin 3，是一种由492个氨基酸组成的蛋白质，在细胞应激反应中发挥着关键作用，特别是在调节细胞生长和存活方面。SESN3广泛表达，属于sestrin家族，该家族在氧化应激和DNA损伤时上调。SESN3激活一磷酸腺苷活化蛋白激酶（AMPK），后者是细胞中重要的能量传感器，有助于维持细胞内环境稳定。SESN3通过抑制雷帕霉素靶蛋白（TOR）通路，促进细胞自噬和代谢过程调节，因此SESN3对于细胞适应压力至关重要。SESN3基因位于人类第11号染色体上，该染色体上包含1400多个基因，与多种遗传疾病有关，包括杰维尔-兰格-尼尔森综合征和尼曼-匹克病。SESN3的多种可变剪接异构体凸显了SESN3在人类健康和疾病中的调节和功能的复杂性。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    SESN3 抗体 (2C9) 参考文献:

    1. 通过对已知人类基因的分析，确定三个 11p11.2 候选肝肿瘤抑制因子。  |  Ricketts, SL., et al. 2003. Mol Carcinog. 36: 90-9. PMID: 12557265
    2. PA26 是人类异位症的候选基因：在人类和小鼠中鉴定出一个新的 PA26 相关基因家族。  |  Peeters, H., et al. 2003. Hum Genet. 112: 573-80. PMID: 12607115
    3. 子宫内膜癌的差异甲基化杂交体阵列揭示了两种新型癌症特异性甲基化标记。  |  Zighelboim, I., et al. 2007. Clin Cancer Res. 13: 2882-9. PMID: 17504987
    4. 胰岛素家族基因的抑制有助于致癌物质 Ras 诱导的活性氧上调和遗传不稳定性。  |  Kopnin, PB., et al. 2007. Cancer Res. 67: 4671-8. PMID: 17510393
    5. p53 靶基因 sestrin1 和 sestrin2 将基因毒性应激和 mTOR 信号转导联系在一起。  |  Budanov, AV. and Karin, M. 2008. Cell. 134: 451-60. PMID: 18692468
    6. Akt 决定复制衰老和氧化性或致癌性早衰，并使细胞对氧化性凋亡敏感。  |  Nogueira, V., et al. 2008. Cancer Cell. 14: 458-70. PMID: 19061837
    7. 用单一 shRNA 表达慢病毒载体高效下调多个 mRNA 靶标。  |  Chumakov, SP., et al. 2010. Plasmid. 63: 143-9. PMID: 20064551
    8. Sestrin 作为 TOR 的反馈抑制剂，可预防与年龄有关的病变。  |  Lee, JH., et al. 2010. Science. 327: 1223-8. PMID: 20203043
    9. FoxOs 通过诱导 Sestrin3 和 Rictor 的表达，抑制 mTORC1 并激活 Akt。  |  Chen, CC., et al. 2010. Dev Cell. 18: 592-604. PMID: 20412774

    订购信息

    产品名称产品编号规格价格数量收藏夹

    SESN3 抗体 (2C9)

    sc-517092
    100 µg/ml
    		RMB2377.00

    SESN3 (2C9): m-IgG Fc BP-HRP 套装

    sc-541095
    100 µg Ab; 10 µg BP
    		RMB2662.00

    SESN3 (2C9): m-IgG1 BP-HRP 套装

    sc-542577
    100 µg Ab; 20 µg BP
    		RMB2662.00

    Please give me information (published data) on the usage of this AB (sc-517092) in ELISA. A similar question is for all other anti-Sestrin (human only) antibodies. Thanks

    Asked by: Meloman
    Thank you for your question. We do not have any publications for ELISA. We have a on year warranty from date of purchase . Here is our protocol: https://www.scbt.com/resources/protocols/elisa-assays. This SESN antibody has only been recommended for human. Here is a SESN antibody for mouse ,rat and human : https://www.scbt.com/p/sesn2-antibody-d-4
    Answered by: BlakeJ
    Date published: 2023-02-15

    For Western Blot, is it recommended to use denatured or non-denatured conditions with SESN3 (2C9): sc-517092 antibody?

    Asked by: Randy McDonald
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 5 out of 5 by from Good for Western BlotAntibody detects human recombinant SESN3 and SESN3 in human pancreas tissue extract by Western blot -SCBT QC
    Date published: 2023-09-14
    Rated 5 out of 5 by from Great on WBI used this antibody to confirm the SESN3 KO cells, it worked very well (1:200 in 5% milk).
    Date published: 2018-10-16
    Rated 5 out of 5 by from Works well in human cells, validated by KOGave a strong band at the right size by western blot in lysates from HEK293T cells. This band was not present in Sesn3 knockout HEK293T cells.
    Date published: 2018-01-18
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    SESN3 抗体 (2C9) is rated 5.0 out of 5 by 3.
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