Date published: 2025-9-7

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Serine racemase 抗体 (A-4): sc-365217

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说明书
  • Serine racemase 抗体 A-4 是小鼠单克隆 IgG1 κ,Serine racemase抗体, 在6篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列191-340位于human物种的Serine racemase的C-terminus
  • Serine racemase 抗体 (A-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Serine racemase; 也和以下物种反应,包括: 和 equine, canine, bovine and porcine
  • 抗Serine racemase抗体(A-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Serine racemase (A-4): sc-365217免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Serine racemase 抗体 (A-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Serine racemase 抗体 (A-4) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

丝氨酸消旋酶抗体(A-4)是一种IgG1κ小鼠单克隆丝氨酸消旋酶抗体(也称为丝氨酸消旋酶抗体),能够通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的丝氨酸消旋酶蛋白。丝氨酸消旋酶抗体(A-4)既以非偶联型抗丝氨酸消旋酶抗体形式供应,也提供多种偶联型抗丝氨酸消旋酶抗体形式,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。过去普遍认为D型氨基酸在细菌中较为突出,而在哺乳动物中则不存在。然而,后来发现D-丝氨酸在哺乳动物的大脑和各种体液中含量很高。D-丝氨酸能激活N-甲基-D-天冬氨酸(NMDA)受体--这些分子在学习、大脑生长和脑细胞死亡中发挥着重要作用。丝氨酸消旋酶是一种催化L-丝氨酸形成D-丝氨酸的酶。丝氨酸消旋酶属于吡哆醛-5'磷酸依赖性酶家族,定位于大鼠大脑的胶质细胞中。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Serine racemase 抗体 (A-4) 参考文献:

  1. 丝氨酸消旋酶:一种合成 D-丝氨酸以调节谷氨酸-N-甲基-D-天冬氨酸神经传递的神经胶质酶。  |  Wolosker, H., et al. 1999. Proc Natl Acad Sci U S A. 96: 13409-14. PMID: 10557334
  2. 人类丝氨酸消旋酶的特征和定位。  |  Xia, M., et al. 2004. Brain Res Mol Brain Res. 125: 96-104. PMID: 15193426
  3. 许旺细胞和会厌成纤维细胞表达丝氨酸消旋酶  |  Wu, S., et al. 2004. Brain Res. 1020: 161-6. PMID: 15312798
  4. 炎症刺激对丝氨酸消旋酶的诱导依赖于 AP-1。  |  Wu, S. and Barger, SW. 2004. Ann N Y Acad Sci. 1035: 133-46. PMID: 15681805
  5. D -丝氨酸和丝氨酸消旋酶在实验性颞叶癫痫中的潜在作用。  |  Ryu, HJ., et al. 2010. J Neurosci Res. 88: 2469-82. PMID: 20623543
  6. 丝氨酸消旋酶功能缺失突变可减轻糖尿病小鼠视网膜神经节细胞的缺失。  |  Jiang, H., et al. 2018. Exp Eye Res. 175: 90-97. PMID: 29913163
  7. 精神分裂症中 NMDA 受体功能低下的起源。  |  Nakazawa, K. and Sapkota, K. 2020. Pharmacol Ther. 205: 107426. PMID: 31629007
  8. 丝氨酸消旋酶抑制剂的局部给药对激光引起的脉络膜血管病变的影响  |  Wang, S., et al. 2024. Transl Vis Sci Technol. 13: 24. PMID: 39136959
  9. 患有和未患有神经精神疾病的人死后大脑和脊髓中的游离 D-丝氨酸。  |  Kumashiro, S., et al. 1995. Brain Res. 681: 117-25. PMID: 7552268
  10. 内源性突触调节剂 D-丝氨酸:定域到星形胶质细胞和谷氨酸刺激释放。  |  Schell, MJ., et al. 1995. Proc Natl Acad Sci U S A. 92: 3948-52. PMID: 7732010
  11. 缺乏 D-氨基酸氧化酶的突变小鼠中枢神经系统和血清中的游离 D-丝氨酸, D-天冬氨酸和 D-丙氨酸。  |  Hashimoto, A., et al. 1993. Neurosci Lett. 152: 33-6. PMID: 8100053
  12. 丝氨酸消旋酶的纯化:神经调节剂 D-丝氨酸的生物合成。  |  Wolosker, H., et al. 1999. Proc Natl Acad Sci U S A. 96: 721-5. PMID: 9892700

订购信息

产品名称产品编号规格价格数量收藏夹

Serine racemase 抗体 (A-4)

sc-365217
200 µg/ml
RMB2377.00

Serine racemase (A-4): m-IgG Fc BP-HRP 套装

sc-527341
200 µg Ab; 10 µg BP
RMB2662.00

Serine racemase (A-4): m-IgG1 BP-HRP 套装

sc-532714
200 µg Ab; 20 µg BP
RMB2662.00

Serine racemase 抗体 (A-4) AC

sc-365217 AC
500 µg/ml, 25% agarose
RMB3129.00

Serine racemase 抗体 (A-4) HRP

sc-365217 HRP
200 µg/ml
RMB2377.00

Serine racemase 抗体 (A-4) FITC

sc-365217 FITC
200 µg/ml
RMB2482.00

Serine racemase 抗体 (A-4) PE

sc-365217 PE
200 µg/ml
RMB2580.00

Serine racemase 抗体 (A-4) Alexa Fluor® 488

sc-365217 AF488
200 µg/ml
RMB2685.00

Serine racemase 抗体 (A-4) Alexa Fluor® 546

sc-365217 AF546
200 µg/ml
RMB2685.00

Serine racemase 抗体 (A-4) Alexa Fluor® 594

sc-365217 AF594
200 µg/ml
RMB2685.00

Serine racemase 抗体 (A-4) Alexa Fluor® 647

sc-365217 AF647
200 µg/ml
RMB2685.00

Serine racemase 抗体 (A-4) Alexa Fluor® 680

sc-365217 AF680
200 µg/ml
RMB2685.00

Serine racemase 抗体 (A-4) Alexa Fluor® 790

sc-365217 AF790
200 µg/ml
RMB2685.00

Can Serine racemase (A-4): sc-365217 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: cjMara
Thank you for your question. Yes, Serine racemase (A-4): sc-365217 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 4 out of 5 by from WB test for serine racemase antibodyThis is a good antibody and it works in mouse tissues as liver and brain. Signal is strong and background is clean.
Date published: 2023-02-01
Rated 5 out of 5 by from Superb antibodyIn my lab, we have tested many commercial antibodies against serine racemase. Most are not specific. The monoclonal antibody sc365217 show highly specific signal as we validated using serine racemase knock-out mice.
Date published: 2018-05-16
Rated 5 out of 5 by from Exceptional immunoperoxidase cytoplasmicExceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
Date published: 2015-02-04
Rated 5 out of 5 by from Great Western Blot data of Serine racemaseGreat Western Blot data of Serine racemase expression in HEK293 whole cell lysate and mouse brain tissue extract . -SCBT QC
Date published: 2014-11-23
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Serine racemase 抗体 (A-4) is rated 4.8 out of 5 by 4.
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